abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
LFR1	DIVLSQSPAILSASPGEKVTMTC	1 - 23	23
CDR-L1	RASSSVSYMH	24 - 33	10
LFR2	WYQQKPGSSPKPWIY	34 - 48	15
CDR-L2	ATSNLAS	49 - 55	7
LFR3	GVPARFSGSGSGTSYSLTISRVEAEDAATYYC	56 - 87	32
CDR-L3	QQWISNPPT	88 - 96	9
LFR4	FGAGTKLELK	97 - 106	10
			106

Region	Definition	Sequence Fragment	Residues	Length
LFR1	Chothia	DIVLSQSPAILSASPGEKVTMTC------	1 - 23	23
	AbM	DIVLSQSPAILSASPGEKVTMTC------	1 - 23	23
	Kabat	DIVLSQSPAILSASPGEKVTMTC------	1 - 23	23
	Contact	DIVLSQSPAILSASPGEKVTMTCRASSSV	1 - 29	29
	IMGT	DIVLSQSPAILSASPGEKVTMTCRAS---	1 - 26	26
CDR-L1	Chothia	RASSSVSYMH--	24 - 33	10
	AbM	RASSSVSYMH--	24 - 33	10
	Kabat	RASSSVSYMH--	24 - 33	10
	Contact	------SYMHWY	30 - 35	6
	IMGT	---SSVSY----	27 - 31	5
LFR2	Chothia	--WYQQKPGSSPKPWIY	34 - 48	15
	AbM	--WYQQKPGSSPKPWIY	34 - 48	15
	Kabat	--WYQQKPGSSPKPWIY	34 - 48	15
	Contact	----QQKPGSSPK----	36 - 44	9
	IMGT	MHWYQQKPGSSPKPWIY	32 - 48	17
CDR-L2	Chothia	----ATSNLAS	49 - 55	7
	AbM	----ATSNLAS	49 - 55	7
	Kabat	----ATSNLAS	49 - 55	7
	Contact	PWIYATSNLA-	45 - 54	10
	IMGT	----AT-----	49 - 50	2
LFR3	Chothia	-----GVPARFSGSGSGTSYSLTISRVEAEDAATYYC	56 - 87	32
	AbM	-----GVPARFSGSGSGTSYSLTISRVEAEDAATYYC	56 - 87	32
	Kabat	-----GVPARFSGSGSGTSYSLTISRVEAEDAATYYC	56 - 87	32
	Contact	----SGVPARFSGSGSGTSYSLTISRVEAEDAATYYC	55 - 87	33
	IMGT	SNLASGVPARFSGSGSGTSYSLTISRVEAEDAATYYC	51 - 87	37
CDR-L3	Chothia	QQWISNPPT	88 - 96	9
	AbM	QQWISNPPT	88 - 96	9
	Kabat	QQWISNPPT	88 - 96	9
	Contact	QQWISNPP-	88 - 95	8
	IMGT	QQWISNPPT	88 - 96	9
LFR4	Chothia	-FGAGTKLELK	97 - 106	10
	AbM	-FGAGTKLELK	97 - 106	10
	Kabat	-FGAGTKLELK	97 - 106	10
	Contact	TFGAGTKLELK	96 - 106	11
	IMGT	-FGAGTKLELK	97 - 106	10

Accession & Annotations

Accession	AAG36947.1
Source	abYsis-EMBL-IG AF277092 Submitted 05-DEC-2000 Updated 05-DEC-2000
Name	murine B9E9 antibody light chain vl region
Organism	Synthetic construct
Chain Type	Light
Pairing	None
Identical Protein Sequences	None
References	Schultz J., Lin Y., Sanderson J., Zuo Y., Stone D., Mallett R., Wilbert S., Axworthy D. 'A tetravalent single-chain antibody-streptavidin fusion protein for pretargeted lymphoma therapy' Cancer Res. 60(23):6663-6669(2000). Lin Y., Schultz J. Submitted (13-JUN-2000) to the INSDC. Molecular Biology, NeoRx Corp., 410 W Harrison St., Seattle, WA 98119, USA

Tools

Sequences

Amino Acid Sequence:

DIVLSQSPAILSASPGEKVTMTCRASSSVSYMHWYQQKPGSSPKPWIYATSNLASGVPAR
FSGSGSGTSYSLTISRVEAEDAATYYCQQWISNPPTFGAGTKLELK

DNA Sequence:

gacatcgtgctgtcgcagtctccagcaatcctgtctgcatctccaggggagaaggtcaca
atgacttgcagggccagctcaagtgtaagttacatgcactggtaccagcagaagccagga
tcctcccccaaaccctggatttatgccacatccaacctggcttctggagtccctgctcgc
ttcagtggcagtgggtctgggacctcttactctctcacaatcagcagagtggaggctgaa
gatgctgccacttattactgccagcagtggattagtaacccacccacgttcggtgctggg
accaagctggagctgaag

Data Source:

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