abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	DVQLQASGGGVVQPGGSLRLSCAAHDPIFD	1 - 30	30
CDR-H1	KNLMG	31 - 35	5
HFR2	WGRQAPGKQREYVA	36 - 49	14
CDR-H2	TISGSGGTNYASSVEG	50 - 65	16
HFR3	RFTISRDNAKKTVYLQMNDLKPEDTAVYYCNS	66 - 97	32
CDR-H3	AFAI	98 - 101	4
HFR4	WGQGTQVTVSS	102 - 112	11
			112

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	DVQLQASGGGVVQPGGSLRLSCAAH-----	1 - 25	25
	AbM	DVQLQASGGGVVQPGGSLRLSCAAH-----	1 - 25	25
	Kabat	DVQLQASGGGVVQPGGSLRLSCAAHDPIFD	1 - 30	30
	Contact	DVQLQASGGGVVQPGGSLRLSCAAHDPIF-	1 - 29	29
	IMGT	DVQLQASGGGVVQPGGSLRLSCAAH-----	1 - 25	25
CDR-H1	Chothia	DPIFDKN---	26 - 32	7
	AbM	DPIFDKNLMG	26 - 35	10
	Kabat	-----KNLMG	31 - 35	5
	Contact	----DKNLMG	30 - 35	6
	IMGT	DPIFDKNL--	26 - 33	8
HFR2	Chothia	LMGWGRQAPGKQREYVATI	33 - 51	19
	AbM	---WGRQAPGKQREYVA--	36 - 49	14
	Kabat	---WGRQAPGKQREYVA--	36 - 49	14
	Contact	---WGRQAPGKQRE-----	36 - 46	11
	IMGT	-MGWGRQAPGKQREYVAT-	34 - 50	17
CDR-H2	Chothia	-----SGSGG---------	52 - 56	5
	AbM	---TISGSGGTN-------	50 - 58	9
	Kabat	---TISGSGGTNYASSVEG	50 - 65	16
	Contact	YVATISGSGGTN-------	47 - 58	12
	IMGT	----ISGSGGT--------	51 - 57	7
HFR3	Chothia	TNYASSVEGRFTISRDNAKKTVYLQMNDLKPEDTAVYYCNS	57 - 97	41
	AbM	--YASSVEGRFTISRDNAKKTVYLQMNDLKPEDTAVYYCNS	59 - 97	39
	Kabat	---------RFTISRDNAKKTVYLQMNDLKPEDTAVYYCNS	66 - 97	32
	Contact	--YASSVEGRFTISRDNAKKTVYLQMNDLKPEDTAVYYC--	59 - 95	37
	IMGT	-NYASSVEGRFTISRDNAKKTVYLQMNDLKPEDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--AFAI	98 - 101	4
	AbM	--AFAI	98 - 101	4
	Kabat	--AFAI	98 - 101	4
	Contact	NSAFA-	96 - 100	5
	IMGT	NSAFAI	96 - 101	6
HFR4	Chothia	-WGQGTQVTVSS	102 - 112	11
	AbM	-WGQGTQVTVSS	102 - 112	11
	Kabat	-WGQGTQVTVSS	102 - 112	11
	Contact	IWGQGTQVTVSS	101 - 112	12
	IMGT	-WGQGTQVTVSS	102 - 112	11

Accession & Annotations

Accession	CAE84872.1
Source	abYsis-EMBL-IG AJ617284 Submitted 09-DEC-2004 Updated 14-DEC-2004
Name	AFAI antibody
Organism	Homo sapiens
Human Subgroup	Heavy chain subgroup III
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	abYsis-EMBL-IG: CAE84869.1
References	Zhang J. Submitted (09-DEC-2003) to the INSDC. Zhang J., Institute for Biological Sciences, National Research Council, 100 Sussex Dr., Ottawa, Ontario, K1A 0R6, CANADA. Zhang J., Li Q., Nguyen T.D., Tremblay T.L., Stone E., Kelly J., MacKenzie R. 'A pentavalent single domain antibody approach to tumor antibody discovery and the development of novel proteomics reagents' Unpublished.

Tools

Sequences

Amino Acid Sequence:

DVQLQASGGGVVQPGGSLRLSCAAHDPIFDKNLMGWGRQAPGKQREYVATISGSGGTNYA
SSVEGRFTISRDNAKKTVYLQMNDLKPEDTAVYYCNSAFAIWGQGTQVTVSS

DNA Sequence:

atgaaaaaaaccgctatcgcgatcgcagttgcactggctggtttcgctaccgttgcgcag
gccgatgtgcagctgcaggcgtctgggggaggcgtggtgcagcctggggggtctctgaga
ctctcctgtgcagcccatgatcccatcttcgataagaatctcatgggctggggccgccag
gctccaggaaagcagcgcgaatatgtcgcgactattagtggtagtggtggaacaaattat
gcaagctccgttgagggccgattcaccatctctagagacaacgccaagaagacggtgtat
ctgcaaatgaacgacctgaaacctgaggacacggccgtctattactgtaactcagctttt
gctatctggggccaggggacccaggtcaccgtctcctcagggcccggcggcggctccggt
ggcggcggttccacgcctgattgtgtaactggaaaggtggagtatacaaaatataatgat
gaagatacctttacagttaaagtgggtgataaagaattatttaccaacagagcgaatctt
cagtctcttcttctcagtgcgcaaattacggggatgactgtaaccattaaaactaatgcc
tgtcataatggagggggattcagcgaagttatttttcgtggcggaggtgggtccggacta
gccggatccgaacaaaaactgatcagcgaagaagatctgaaccatcaccatcaccattag

Data Source:

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