abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	VQLQESATELVKPGASVKISCKASGYSFI	1 - 29	29
CDR-H1	VHYIN	30 - 34	5
HFR2	WVKQKPGQGLEWIG	35 - 48	14
CDR-H2	CFFPGSGNSKYIENFRG	49 - 65	17
HFR3	KATLTVDTSSSTAYMQLSSLTSEDTAVYFCAR	66 - 97	32
CDR-H3	DDSDGAMDY	98 - 106	9
HFR4	WGQGTTVTVSS	107 - 117	11
			117

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	VQLQESATELVKPGASVKISCKAS-----	1 - 24	24
	AbM	VQLQESATELVKPGASVKISCKAS-----	1 - 24	24
	Kabat	VQLQESATELVKPGASVKISCKASGYSFI	1 - 29	29
	Contact	VQLQESATELVKPGASVKISCKASGYSF-	1 - 28	28
	IMGT	VQLQESATELVKPGASVKISCKAS-----	1 - 24	24
CDR-H1	Chothia	GYSFIVH---	25 - 31	7
	AbM	GYSFIVHYIN	25 - 34	10
	Kabat	-----VHYIN	30 - 34	5
	Contact	----IVHYIN	29 - 34	6
	IMGT	GYSFIVHY--	25 - 32	8
HFR2	Chothia	YINWVKQKPGQGLEWIGCF	32 - 50	19
	AbM	---WVKQKPGQGLEWIG--	35 - 48	14
	Kabat	---WVKQKPGQGLEWIG--	35 - 48	14
	Contact	---WVKQKPGQGLE-----	35 - 45	11
	IMGT	-INWVKQKPGQGLEWIGC-	33 - 49	17
CDR-H2	Chothia	-----FPGSGN---------	51 - 56	6
	AbM	---CFFPGSGNSK-------	49 - 58	10
	Kabat	---CFFPGSGNSKYIENFRG	49 - 65	17
	Contact	WIGCFFPGSGNSK-------	46 - 58	13
	IMGT	----FFPGSGNS--------	50 - 57	8
HFR3	Chothia	SKYIENFRGKATLTVDTSSSTAYMQLSSLTSEDTAVYFCAR	57 - 97	41
	AbM	--YIENFRGKATLTVDTSSSTAYMQLSSLTSEDTAVYFCAR	59 - 97	39
	Kabat	---------KATLTVDTSSSTAYMQLSSLTSEDTAVYFCAR	66 - 97	32
	Contact	--YIENFRGKATLTVDTSSSTAYMQLSSLTSEDTAVYFC--	59 - 95	37
	IMGT	-KYIENFRGKATLTVDTSSSTAYMQLSSLTSEDTAVYFC--	58 - 95	38
CDR-H3	Chothia	--DDSDGAMDY	98 - 106	9
	AbM	--DDSDGAMDY	98 - 106	9
	Kabat	--DDSDGAMDY	98 - 106	9
	Contact	ARDDSDGAMD-	96 - 105	10
	IMGT	ARDDSDGAMDY	96 - 106	11
HFR4	Chothia	-WGQGTTVTVSS	107 - 117	11
	AbM	-WGQGTTVTVSS	107 - 117	11
	Kabat	-WGQGTTVTVSS	107 - 117	11
	Contact	YWGQGTTVTVSS	106 - 117	12
	IMGT	-WGQGTTVTVSS	107 - 117	11

Accession & Annotations

Accession	AAQ16203.1
Source	abYsis-EMBL-IG AY337618 Submitted 05-AUG-2003 Updated 23-MAR-2004
Name	immunoglobulin variable heavy chain scFv anti-CMV paratope
Organism	Synthetic construct
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Chua K.H., Tan C.S., Khalid N., Harikrishna J.A., Othman R.Y. 'Synthesis of a soluble flag-tagged single chain variable fragment (scFv) antibody targeting cucumber mosaic virus (CMV) coat protein' Asia Pac. J. Mol. Biol. Biotechnol. 11(2):93-100(2003). Chua K.H., Tan C.S., Khalid N., Harikrishna J.A., Othman R.Y. Submitted (09-JUL-2003) to the INSDC. Institute of Biological Sciences, University of Malaya, Kuala Lumpur, Kuala Lumpur 50603, Malaysia

Tools

Sequences

Amino Acid Sequence:

VQLQESATELVKPGASVKISCKASGYSFIVHYINWVKQKPGQGLEWIGCFFPGSGNSKYI
ENFRGKATLTVDTSSSTAYMQLSSLTSEDTAVYFCARDDSDGAMDYWGQGTTVTVSS

DNA Sequence:

gtgcagctgcaggagtcagcaactgagctggtgaagcctggggcttcagtgaagatatcc
tgcaaggcttctggctactccttcattgtccactatataaactgggtgaagcagaagcct
ggacagggacttgagtggattggatgcttttttcctggaagcggtaatagtaagtacatt
gagaacttcaggggcaaggccacattgactgtagacacatcctccagtacagcctacatg
cagctcagcagcctgacatctgaggacactgctgtctatttctgtgcaagggatgattcc
gacggagctatggactactggggccaagggaccacggtcaccgtctcctca

Data Source:

Alignment settings:

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