abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	VKLQQSGGGLVQPGGSLKLSCAASGFDFS	1 - 29	29
CDR-H1	RYWMS	30 - 34	5
HFR2	WVRQAPGKGLEWIG	35 - 48	14
CDR-H2	EINPDSSTINYTPSLKD	49 - 65	17
HFR3	TFIISRDNAKNTLYLQMSKVRSEDTALYYCAR	66 - 97	32
CDR-H3	QGYDGYHWYFDV	98 - 109	12
HFR4	WGQGTTVTVSS	110 - 120	11
Tail	ESLDL	120 - 125	5
			125

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	VKLQQSGGGLVQPGGSLKLSCAAS-----	1 - 24	24
	AbM	VKLQQSGGGLVQPGGSLKLSCAAS-----	1 - 24	24
	Kabat	VKLQQSGGGLVQPGGSLKLSCAASGFDFS	1 - 29	29
	Contact	VKLQQSGGGLVQPGGSLKLSCAASGFDF-	1 - 28	28
	IMGT	VKLQQSGGGLVQPGGSLKLSCAAS-----	1 - 24	24
CDR-H1	Chothia	GFDFSRY---	25 - 31	7
	AbM	GFDFSRYWMS	25 - 34	10
	Kabat	-----RYWMS	30 - 34	5
	Contact	----SRYWMS	29 - 34	6
	IMGT	GFDFSRYW--	25 - 32	8
HFR2	Chothia	WMSWVRQAPGKGLEWIGEI	32 - 50	19
	AbM	---WVRQAPGKGLEWIG--	35 - 48	14
	Kabat	---WVRQAPGKGLEWIG--	35 - 48	14
	Contact	---WVRQAPGKGLE-----	35 - 45	11
	IMGT	-MSWVRQAPGKGLEWIGE-	33 - 49	17
CDR-H2	Chothia	-----NPDSST---------	51 - 56	6
	AbM	---EINPDSSTIN-------	49 - 58	10
	Kabat	---EINPDSSTINYTPSLKD	49 - 65	17
	Contact	WIGEINPDSSTIN-------	46 - 58	13
	IMGT	----INPDSSTI--------	50 - 57	8
HFR3	Chothia	INYTPSLKDTFIISRDNAKNTLYLQMSKVRSEDTALYYCAR	57 - 97	41
	AbM	--YTPSLKDTFIISRDNAKNTLYLQMSKVRSEDTALYYCAR	59 - 97	39
	Kabat	---------TFIISRDNAKNTLYLQMSKVRSEDTALYYCAR	66 - 97	32
	Contact	--YTPSLKDTFIISRDNAKNTLYLQMSKVRSEDTALYYC--	59 - 95	37
	IMGT	-NYTPSLKDTFIISRDNAKNTLYLQMSKVRSEDTALYYC--	58 - 95	38
CDR-H3	Chothia	--QGYDGYHWYFDV	98 - 109	12
	AbM	--QGYDGYHWYFDV	98 - 109	12
	Kabat	--QGYDGYHWYFDV	98 - 109	12
	Contact	ARQGYDGYHWYFD-	96 - 108	13
	IMGT	ARQGYDGYHWYFDV	96 - 109	14
HFR4	Chothia	-WGQGTTVTVSS	110 - 120	11
	AbM	-WGQGTTVTVSS	110 - 120	11
	Kabat	-WGQGTTVTVSS	110 - 120	11
	Contact	VWGQGTTVTVSS	109 - 120	12
	IMGT	-WGQGTTVTVSS	110 - 120	11

Accession & Annotations

Accession	ABO26565.1
Source	abYsis-EMBL-IG EF418574 Submitted 13-MAR-2007 Updated 17-NOV-2007
Name	anti-rabies glycoprotein immunoglobulin heavy chain variable region
Organism	Synthetic construct
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Mousli M., Turki I., Kharmachi H., Saadi M., Dellagi K. 'Recombinant single-chain Fv antibody fragment-alkaline phosphatase conjugate: a novel in vitro tool to estimate rabies viral glycoprotein antigen in vaccine manufacture' J. Virol. Methods 146(1-2):246-256(2007). Mousli M., Turki I., Kharmachi H., Dellagi K. Submitted (02-FEB-2007) to the INSDC. Immuno-biotechnology, Institut Pasteur de Tunis, 13, Place Pasteur, Tunis-Belvedere 1002, Tunisia Mousli M., Turki I., Kharmachi H., Dellagi K. 'Single chain antibody produced from PCR amplification' Unpublished.

Tools

Sequences

Amino Acid Sequence:

VKLQQSGGGLVQPGGSLKLSCAASGFDFSRYWMSWVRQAPGKGLEWIGEINPDSSTINYT
PSLKDTFIISRDNAKNTLYLQMSKVRSEDTALYYCARQGYDGYHWYFDVWGQGTTVTVSS
ESLDL

DNA Sequence:

gtcaagctgcagcagtcaggaggtggcctggtgcagcctggaggatccctgaaactctcc
tgtgcagcctcaggattcgattttagcagatactggatgagttgggtccggcaggctcca
gggaaagggctagaatggattggagaaattaatccagatagcagtacgattaactatacg
ccatctctaaaggatacattcatcatctccagagacaacgccaaaaatacgctgtacctg
caaatgagcaaagtgagatctgaggacacagccctttattactgtgcaagacagggttac
gacggataccactggtacttcgatgtctggggccaagggaccacggtcaccgtctcctca
gaatctctagatcta

Data Source:

Alignment settings:

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