abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	MAEV	1 - 4	4
HFR1	QLQLQQSGPELMKPGASVKISCKASGYSFT	5 - 34	30
CDR-H1	SYYMH	35 - 39	5
HFR2	WVKQSHGKSLEWIG	40 - 53	14
CDR-H2	YIDPFNGGTSYNQKFKD	54 - 70	17
HFR3	KATLTVDKSSTTAYIHLSSLTSEDSAVYYCAR	71 - 102	32
CDR-H3	GVLRRWFFDV	103 - 112	10
HFR4	WGAGTSVTVSS	113 - 123	11
			123

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QLQLQQSGPELMKPGASVKISCKAS-----	5 - 29	25
	AbM	QLQLQQSGPELMKPGASVKISCKAS-----	5 - 29	25
	Kabat	QLQLQQSGPELMKPGASVKISCKASGYSFT	5 - 34	30
	Contact	QLQLQQSGPELMKPGASVKISCKASGYSF-	5 - 33	29
	IMGT	QLQLQQSGPELMKPGASVKISCKAS-----	5 - 29	25
CDR-H1	Chothia	GYSFTSY---	30 - 36	7
	AbM	GYSFTSYYMH	30 - 39	10
	Kabat	-----SYYMH	35 - 39	5
	Contact	----TSYYMH	34 - 39	6
	IMGT	GYSFTSYY--	30 - 37	8
HFR2	Chothia	YMHWVKQSHGKSLEWIGYI	37 - 55	19
	AbM	---WVKQSHGKSLEWIG--	40 - 53	14
	Kabat	---WVKQSHGKSLEWIG--	40 - 53	14
	Contact	---WVKQSHGKSLE-----	40 - 50	11
	IMGT	-MHWVKQSHGKSLEWIGY-	38 - 54	17
CDR-H2	Chothia	-----DPFNGG---------	56 - 61	6
	AbM	---YIDPFNGGTS-------	54 - 63	10
	Kabat	---YIDPFNGGTSYNQKFKD	54 - 70	17
	Contact	WIGYIDPFNGGTS-------	51 - 63	13
	IMGT	----IDPFNGGT--------	55 - 62	8
HFR3	Chothia	TSYNQKFKDKATLTVDKSSTTAYIHLSSLTSEDSAVYYCAR	62 - 102	41
	AbM	--YNQKFKDKATLTVDKSSTTAYIHLSSLTSEDSAVYYCAR	64 - 102	39
	Kabat	---------KATLTVDKSSTTAYIHLSSLTSEDSAVYYCAR	71 - 102	32
	Contact	--YNQKFKDKATLTVDKSSTTAYIHLSSLTSEDSAVYYC--	64 - 100	37
	IMGT	-SYNQKFKDKATLTVDKSSTTAYIHLSSLTSEDSAVYYC--	63 - 100	38
CDR-H3	Chothia	--GVLRRWFFDV	103 - 112	10
	AbM	--GVLRRWFFDV	103 - 112	10
	Kabat	--GVLRRWFFDV	103 - 112	10
	Contact	ARGVLRRWFFD-	101 - 111	11
	IMGT	ARGVLRRWFFDV	101 - 112	12
HFR4	Chothia	-WGAGTSVTVSS	113 - 123	11
	AbM	-WGAGTSVTVSS	113 - 123	11
	Kabat	-WGAGTSVTVSS	113 - 123	11
	Contact	VWGAGTSVTVSS	112 - 123	12
	IMGT	-WGAGTSVTVSS	113 - 123	11

Accession & Annotations

Accession	AFM94005.1
Source	abYsis-EMBL-IG JN316285 Submitted 13-OCT-2014 Updated 13-OCT-2014
Name	LETscFv antibody heavy chain variable region
Organism	Synthetic construct
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Kulshreshtha P., Tiwari A., Sinha S., Bhatnagar R. Submitted (17-JUL-2011) to the INSDC. School of Biotechnology, Jawaharlal Nehru University, New Mehrauli Road, Delhi, New Delhi 110067, India Kulshreshtha P., Tiwari A., Sinha S., Bhatnagar R. 'Single chain antibody capable of neutralizing lethal toxin and edema toxin of Bacillus anthracis' Unpublished.

Tools

Sequences

Amino Acid Sequence:

MAEVQLQLQQSGPELMKPGASVKISCKASGYSFTSYYMHWVKQSHGKSLEWIGYIDPFNG
GTSYNQKFKDKATLTVDKSSTTAYIHLSSLTSEDSAVYYCARGVLRRWFFDVWGAGTSVT
VSS

DNA Sequence:

atggccgaggtgcagcttcagctgcagcagtctggacctgagctgatgaagcctggggct
tcagtgaagatatcctgcaaggcttctggttactcattcactagctactacatgcactgg
gtgaagcagagccatggaaagagccttgagtggattggatatattgatcctttcaatggt
ggtactagctacaaccagaaattcaaggacaaggccacattgactgtagacaaatcttcc
accacagcctacatacatctcagcagcctgacatctgaggactctgcagtctattactgt
gcaagaggggtactacggaggtggttcttcgatgtctggggcgcagggacctcagtcacc
gtctcctca

Data Source:

Alignment settings:

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