abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
LFR1	IVMTQTPLSLPVSLGDQASISC	1 - 22	22
CDR-L1	RSSQSLVHSNGNTYLH	23 - 38	16
LFR2	WYLQKPGQSPKLLIY	39 - 53	15
CDR-L2	KVPNRFS	54 - 60	7
LFR3	GVPDRFSGSGSGTDFTLKISRVEAEDLGVYFC	61 - 92	32
CDR-L3	SQSTHVPCT	93 - 101	9
LFR4	FGGGTKLEIKR	102 - 112	11
			112

Region	Definition	Sequence Fragment	Residues	Length
LFR1	Chothia	IVMTQTPLSLPVSLGDQASISC------	1 - 22	22
	AbM	IVMTQTPLSLPVSLGDQASISC------	1 - 22	22
	Kabat	IVMTQTPLSLPVSLGDQASISC------	1 - 22	22
	Contact	IVMTQTPLSLPVSLGDQASISCRSSQSL	1 - 28	28
	IMGT	IVMTQTPLSLPVSLGDQASISCRSS---	1 - 25	25
CDR-L1	Chothia	RSSQSLVHSNGNTYLH--	23 - 38	16
	AbM	RSSQSLVHSNGNTYLH--	23 - 38	16
	Kabat	RSSQSLVHSNGNTYLH--	23 - 38	16
	Contact	------VHSNGNTYLHWY	29 - 40	12
	IMGT	---QSLVHSNGNTY----	26 - 36	11
LFR2	Chothia	--WYLQKPGQSPKLLIY	39 - 53	15
	AbM	--WYLQKPGQSPKLLIY	39 - 53	15
	Kabat	--WYLQKPGQSPKLLIY	39 - 53	15
	Contact	----LQKPGQSPK----	41 - 49	9
	IMGT	LHWYLQKPGQSPKLLIY	37 - 53	17
CDR-L2	Chothia	----KVPNRFS	54 - 60	7
	AbM	----KVPNRFS	54 - 60	7
	Kabat	----KVPNRFS	54 - 60	7
	Contact	LLIYKVPNRF-	50 - 59	10
	IMGT	----KV-----	54 - 55	2
LFR3	Chothia	-----GVPDRFSGSGSGTDFTLKISRVEAEDLGVYFC	61 - 92	32
	AbM	-----GVPDRFSGSGSGTDFTLKISRVEAEDLGVYFC	61 - 92	32
	Kabat	-----GVPDRFSGSGSGTDFTLKISRVEAEDLGVYFC	61 - 92	32
	Contact	----SGVPDRFSGSGSGTDFTLKISRVEAEDLGVYFC	60 - 92	33
	IMGT	PNRFSGVPDRFSGSGSGTDFTLKISRVEAEDLGVYFC	56 - 92	37
CDR-L3	Chothia	SQSTHVPCT	93 - 101	9
	AbM	SQSTHVPCT	93 - 101	9
	Kabat	SQSTHVPCT	93 - 101	9
	Contact	SQSTHVPC-	93 - 100	8
	IMGT	SQSTHVPCT	93 - 101	9
LFR4	Chothia	-FGGGTKLEIKR	102 - 112	11
	AbM	-FGGGTKLEIKR	102 - 112	11
	Kabat	-FGGGTKLEIKR	102 - 112	11
	Contact	TFGGGTKLEIKR	101 - 112	12
	IMGT	-FGGGTKLEIKR	102 - 112	11

Accession & Annotations

Accession	AFM94006.1
Source	abYsis-EMBL-IG JN316286 Submitted 13-OCT-2014 Updated 13-OCT-2014
Name	LETscFv antibody kappa light chain variable region
Organism	Synthetic construct
Chain Type	Light Kappa
Pairing	None
Identical Protein Sequences	None
References	Kulshreshtha P., Tiwari A., Sinha S., Bhatnagar R. Submitted (17-JUL-2011) to the INSDC. School of Biotechnology, Jawaharlal Nehru University, New Mehrauli Road, Delhi, New Delhi 110067, India Kulshreshtha P., Tiwari A., Sinha S., Bhatnagar R. 'Single chain antibody capable of neutralizing lethal toxin and edema toxin of Bacillus anthracis' Unpublished.

Tools

Sequences

Amino Acid Sequence:

IVMTQTPLSLPVSLGDQASISCRSSQSLVHSNGNTYLHWYLQKPGQSPKLLIYKVPNRFS
GVPDRFSGSGSGTDFTLKISRVEAEDLGVYFCSQSTHVPCTFGGGTKLEIKR

DNA Sequence:

attgtgatgacccagactccactctccctgcctgtcagtcttggagatcaagcctccatc
tcttgcagatctagtcagagccttgtacacagtaatggaaacacctatttacattggtac
ctgcagaagccaggccagtctccaaagctcctgatctacaaagttcccaaccgattttct
ggggtcccagacaggttcagtggcagtggatcagggacagatttcacactcaagatcagc
agagtggaggctgaggatctgggagtttatttctgctctcaaagtacacatgttccgtgc
acgttcggagggggcacaaagctggaaatcaaacgg

Data Source:

Alignment settings:

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