abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLQASGGGLVQPGGSLRLACQYSGREGT	1 - 30	30
CDR-H1	TTVG	31 - 34	4
HFR2	WFRQSPGKEREFVA	35 - 48	14
CDR-H2	AIRWTDSRTPHTDS	49 - 62	14
HFR3	RFTTSSDNFKKTAYLQMNGLKPEDTALYYCTE	63 - 94	32
CDR-H3	DTWNSVVTGTAAD	95 - 107	13
HFR4	WSQGTQVTVSS	108 - 118	11
			118

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLQASGGGLVQPGGSLRLACQYS-----	1 - 25	25
	AbM	EVQLQASGGGLVQPGGSLRLACQYS-----	1 - 25	25
	Kabat	EVQLQASGGGLVQPGGSLRLACQYSGREGT	1 - 30	30
	Contact	EVQLQASGGGLVQPGGSLRLACQYSGREG-	1 - 29	29
	IMGT	EVQLQASGGGLVQPGGSLRLACQYS-----	1 - 25	25
CDR-H1	Chothia	GREGTT---	26 - 31	6
	AbM	GREGTTTVG	26 - 34	9
	Kabat	-----TTVG	31 - 34	4
	Contact	----TTTVG	30 - 34	5
	IMGT	GREGTTT--	26 - 32	7
HFR2	Chothia	TVGWFRQSPGKEREFVAAI	32 - 50	19
	AbM	---WFRQSPGKEREFVA--	35 - 48	14
	Kabat	---WFRQSPGKEREFVA--	35 - 48	14
	Contact	---WFRQSPGKERE-----	35 - 45	11
	IMGT	-VGWFRQSPGKEREFVAA-	33 - 49	17
CDR-H2	Chothia	-----RWT---------	51 - 53	3
	AbM	---AIRWTDS-------	49 - 55	7
	Kabat	---AIRWTDSRTPHTDS	49 - 62	14
	Contact	FVAAIRWTDS-------	46 - 55	10
	IMGT	----IRWTD--------	50 - 54	5
HFR3	Chothia	DSRTPHTDSRFTTSSDNFKKTAYLQMNGLKPEDTALYYCTE	54 - 94	41
	AbM	--RTPHTDSRFTTSSDNFKKTAYLQMNGLKPEDTALYYCTE	56 - 94	39
	Kabat	---------RFTTSSDNFKKTAYLQMNGLKPEDTALYYCTE	63 - 94	32
	Contact	--RTPHTDSRFTTSSDNFKKTAYLQMNGLKPEDTALYYC--	56 - 92	37
	IMGT	-SRTPHTDSRFTTSSDNFKKTAYLQMNGLKPEDTALYYC--	55 - 92	38
CDR-H3	Chothia	--DTWNSVVTGTAAD	95 - 107	13
	AbM	--DTWNSVVTGTAAD	95 - 107	13
	Kabat	--DTWNSVVTGTAAD	95 - 107	13
	Contact	TEDTWNSVVTGTAA-	93 - 106	14
	IMGT	TEDTWNSVVTGTAAD	93 - 107	15
HFR4	Chothia	-WSQGTQVTVSS	108 - 118	11
	AbM	-WSQGTQVTVSS	108 - 118	11
	Kabat	-WSQGTQVTVSS	108 - 118	11
	Contact	DWSQGTQVTVSS	107 - 118	12
	IMGT	-WSQGTQVTVSS	108 - 118	11

Accession & Annotations

Accession	AGY46251.1
Source	abYsis-EMBL-IG KF553635 Submitted 30-OCT-2013 Updated 30-OCT-2013
Name	single-chain antibody variable region
Clone	D1
Organism	Synthetic construct
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Zabetakis D., Anderson G.P., Bayya N., Goldman E.R. 'Contributions of the complementarity determining regions to the thermal stability of a single-domain antibody' PLoS One 8(10):E77678-E77678(2013). Zabetakis D., Anderson G.P., Bayya N., Goldman E.R. Submitted (19-AUG-2013) to the INSDC. Center for Bio/Molecular Science and Engineering, US Naval Research Laboratory, 4555 Overlook Ave, Washington, DC 20375, USA

Tools

Sequences

Amino Acid Sequence:

EVQLQASGGGLVQPGGSLRLACQYSGREGTTTVGWFRQSPGKEREFVAAIRWTDSRTPHT
DSRFTTSSDNFKKTAYLQMNGLKPEDTALYYCTEDTWNSVVTGTAADWSQGTQVTVSS

DNA Sequence:

gaggtccagctgcaggcgtctgggggaggattggtgcagcccgggggctctctgcgactc
gcctgtcaatactctggacgcgaaggtaccacgaccgtgggctggttccgccagtctcca
gggaaggagcgtgagtttgttgcagccattcggtggactgacagtaggacaccacataca
gactccagattcaccacctccagcgacaacttcaagaagacggcctatctgcaaatgaac
ggtttgaaacctgaggacacggccctttattactgtacagaagatacctggaactcagtg
gtgacgggtacggccgccgactggagccaggggacccaggtcaccgtctcctca

Data Source:

Alignment settings:

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