abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	M	1 - 1	1
HFR1	DVQLQESGGGSVQVGGSLKLSCAISGYDND	2 - 31	30
CDR-H1	NYCMG	32 - 36	5
HFR2	WFRQTPGKEREKVA	37 - 50	14
CDR-H2	ALNIGGGSPVYADFVRG	51 - 67	17
HFR3	RFTISLDSSKDTLYLLMNAVTPEDTAMYSCAA	68 - 99	32
CDR-H3	IRKPQLYTCRMWKPRADFDI	100 - 119	20
HFR4	WGQGTQVTVSS	120 - 130	11
Tail	LEHHHHHH	130 - 138	8
			138

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	DVQLQESGGGSVQVGGSLKLSCAIS-----	2 - 26	25
	AbM	DVQLQESGGGSVQVGGSLKLSCAIS-----	2 - 26	25
	Kabat	DVQLQESGGGSVQVGGSLKLSCAISGYDND	2 - 31	30
	Contact	DVQLQESGGGSVQVGGSLKLSCAISGYDN-	2 - 30	29
	IMGT	DVQLQESGGGSVQVGGSLKLSCAIS-----	2 - 26	25
CDR-H1	Chothia	GYDNDNY---	27 - 33	7
	AbM	GYDNDNYCMG	27 - 36	10
	Kabat	-----NYCMG	32 - 36	5
	Contact	----DNYCMG	31 - 36	6
	IMGT	GYDNDNYC--	27 - 34	8
HFR2	Chothia	CMGWFRQTPGKEREKVAAL	34 - 52	19
	AbM	---WFRQTPGKEREKVA--	37 - 50	14
	Kabat	---WFRQTPGKEREKVA--	37 - 50	14
	Contact	---WFRQTPGKERE-----	37 - 47	11
	IMGT	-MGWFRQTPGKEREKVAA-	35 - 51	17
CDR-H2	Chothia	-----NIGGGS---------	53 - 58	6
	AbM	---ALNIGGGSPV-------	51 - 60	10
	Kabat	---ALNIGGGSPVYADFVRG	51 - 67	17
	Contact	KVAALNIGGGSPV-------	48 - 60	13
	IMGT	----LNIGGGSP--------	52 - 59	8
HFR3	Chothia	PVYADFVRGRFTISLDSSKDTLYLLMNAVTPEDTAMYSCAA	59 - 99	41
	AbM	--YADFVRGRFTISLDSSKDTLYLLMNAVTPEDTAMYSCAA	61 - 99	39
	Kabat	---------RFTISLDSSKDTLYLLMNAVTPEDTAMYSCAA	68 - 99	32
	Contact	--YADFVRGRFTISLDSSKDTLYLLMNAVTPEDTAMYSC--	61 - 97	37
	IMGT	-VYADFVRGRFTISLDSSKDTLYLLMNAVTPEDTAMYSC--	60 - 97	38
CDR-H3	Chothia	--IRKPQLYTCRMWKPRADFDI	100 - 119	20
	AbM	--IRKPQLYTCRMWKPRADFDI	100 - 119	20
	Kabat	--IRKPQLYTCRMWKPRADFDI	100 - 119	20
	Contact	AAIRKPQLYTCRMWKPRADFD-	98 - 118	21
	IMGT	AAIRKPQLYTCRMWKPRADFDI	98 - 119	22
HFR4	Chothia	-WGQGTQVTVSS	120 - 130	11
	AbM	-WGQGTQVTVSS	120 - 130	11
	Kabat	-WGQGTQVTVSS	120 - 130	11
	Contact	IWGQGTQVTVSS	119 - 130	12
	IMGT	-WGQGTQVTVSS	120 - 130	11

Accession & Annotations

Accession	AJF48582.1
Source	abYsis-EMBL-IG KM885986 Submitted 13-FEB-2015 Updated 13-FEB-2015
Name	single-domain antibody immunoglobulin heavy chain variable region
Clone	Cl-18
Organism	Synthetic construct
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Gupta A.K., Singh A. Submitted (09-OCT-2014) to the INSDC. Veterinary Microbiology, Lala Lajpat Rai University of Veterinary & Animal Sciences, College of Veterinary Sciences, Hisar, Haryana 125004, India Gupta A.K., Singh A. 'LPS-binding single-domain antibody clone 18 selected from phage display library of Indian desert camel (Camelus dromedarius L.)' Unpublished.

Tools

Sequences

Amino Acid Sequence:

MDVQLQESGGGSVQVGGSLKLSCAISGYDNDNYCMGWFRQTPGKEREKVAALNIGGGSPV
YADFVRGRFTISLDSSKDTLYLLMNAVTPEDTAMYSCAAIRKPQLYTCRMWKPRADFDIW
GQGTQVTVSSLEHHHHHH

DNA Sequence:

atggatgtgcagctgcaggagtctggaggaggctcggtgcaggttggaggctctttgaaa
ctctcctgtgcaatttctggatacgacaacgataactactgcatgggctggttccgccaa
acgccagggaaggagcgtgagaaagtcgcggcccttaatattggaggtggtagcccagtc
tacgccgatttcgtgaggggccgattcaccatctccctggactccagcaaggacacactg
tacctcctgatgaatgcagtgacacctgaggacacggccatgtattcctgtgcggcaatc
cgtaagccccaattatatacttgccgtatgtggaaaccaagagctgactttgatatctgg
ggccaggggacccaggtcaccgtctccagcctcgagcaccaccaccaccaccactga

Data Source:

Alignment settings:

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