abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	DVQLQASGGGFVQAGGSLRLTCVASGHTFG	1 - 30	30
CDR-H1	SYAMG	31 - 35	5
HFR2	WFRQAPGKEREFVA	36 - 49	14
CDR-H2	AISWSGGDTYADSVKG	50 - 65	16
HFR3	RFTISRDNAKNTVYLQMNSLEPEDTAVYSCAA	66 - 97	32
CDR-H3	VGARYYISKDAKDYGY	98 - 113	16
HFR4	WGQGTQVTVSS	114 - 124	11
			124

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	DVQLQASGGGFVQAGGSLRLTCVAS-----	1 - 25	25
	AbM	DVQLQASGGGFVQAGGSLRLTCVAS-----	1 - 25	25
	Kabat	DVQLQASGGGFVQAGGSLRLTCVASGHTFG	1 - 30	30
	Contact	DVQLQASGGGFVQAGGSLRLTCVASGHTF-	1 - 29	29
	IMGT	DVQLQASGGGFVQAGGSLRLTCVAS-----	1 - 25	25
CDR-H1	Chothia	GHTFGSY---	26 - 32	7
	AbM	GHTFGSYAMG	26 - 35	10
	Kabat	-----SYAMG	31 - 35	5
	Contact	----GSYAMG	30 - 35	6
	IMGT	GHTFGSYA--	26 - 33	8
HFR2	Chothia	AMGWFRQAPGKEREFVAAI	33 - 51	19
	AbM	---WFRQAPGKEREFVA--	36 - 49	14
	Kabat	---WFRQAPGKEREFVA--	36 - 49	14
	Contact	---WFRQAPGKERE-----	36 - 46	11
	IMGT	-MGWFRQAPGKEREFVAA-	34 - 50	17
CDR-H2	Chothia	-----SWSGG---------	52 - 56	5
	AbM	---AISWSGGDT-------	50 - 58	9
	Kabat	---AISWSGGDTYADSVKG	50 - 65	16
	Contact	FVAAISWSGGDT-------	47 - 58	12
	IMGT	----ISWSGGD--------	51 - 57	7
HFR3	Chothia	DTYADSVKGRFTISRDNAKNTVYLQMNSLEPEDTAVYSCAA	57 - 97	41
	AbM	--YADSVKGRFTISRDNAKNTVYLQMNSLEPEDTAVYSCAA	59 - 97	39
	Kabat	---------RFTISRDNAKNTVYLQMNSLEPEDTAVYSCAA	66 - 97	32
	Contact	--YADSVKGRFTISRDNAKNTVYLQMNSLEPEDTAVYSC--	59 - 95	37
	IMGT	-TYADSVKGRFTISRDNAKNTVYLQMNSLEPEDTAVYSC--	58 - 95	38
CDR-H3	Chothia	--VGARYYISKDAKDYGY	98 - 113	16
	AbM	--VGARYYISKDAKDYGY	98 - 113	16
	Kabat	--VGARYYISKDAKDYGY	98 - 113	16
	Contact	AAVGARYYISKDAKDYG-	96 - 112	17
	IMGT	AAVGARYYISKDAKDYGY	96 - 113	18
HFR4	Chothia	-WGQGTQVTVSS	114 - 124	11
	AbM	-WGQGTQVTVSS	114 - 124	11
	Kabat	-WGQGTQVTVSS	114 - 124	11
	Contact	YWGQGTQVTVSS	113 - 124	12
	IMGT	-WGQGTQVTVSS	114 - 124	11

Accession & Annotations

Accession	AMK98485.1
Source	abYsis-EMBL-IG KU508539 Submitted 02-MAR-2016 Updated 02-MAR-2016
Name	immunoglobulin heavy chain variable region
Clone	Aa
Organism	Synthetic construct
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Turner K.B., Naciri J., Liu J.L., Anderson G.P., Goldman E.R., Zabetakis D. 'Next-Generation Sequencing of a Single Domain Antibody Repertoire Reveals Quality of Phage Display Selected Candidates' PLoS One 11(2):E0149393-E0149393(2016). Turner K.B., Liu J.L., Anderson G.P., Goldman E.R., Zabetakis D. Submitted (07-JAN-2016) to the INSDC. Center for Bio/Molecular Science and Engineering, US Naval Research Laboratory, 4555 Overlook Ave, Washington, DC 20375, USA

Tools

Sequences

Amino Acid Sequence:

DVQLQASGGGFVQAGGSLRLTCVASGHTFGSYAMGWFRQAPGKEREFVAAISWSGGDTYA
DSVKGRFTISRDNAKNTVYLQMNSLEPEDTAVYSCAAVGARYYISKDAKDYGYWGQGTQV
TVSS

DNA Sequence:

gatgtgcagttacaggccagtggtggtgggtttgtccaagccggaggttctctgcgtctg
acatgcgtagcgagtggtcatacgttcggctcctatgcgatgggctggtttcgtcaggct
ccaggcaaagaacgcgagtttgttgccgctatttcctggtcaggcggagatacctatgcc
gattcggtcaaaggccgcttcacgattagccgcgacaatgcgaagaacaccgtatacttg
cagatgaacagcctggaaccggaagataccgcagtgtattcgtgtgcggcagttggcgca
cggtactacatcagcaaagacgcgaaagactatggctattggggtcaagggactcaggtg
accgtgtctagc

Data Source:

Alignment settings:

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