abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLQASGGGLVQPGGSLRLPCAASGLIFG	1 - 30	30
CDR-H1	SYAMG	31 - 35	5
HFR2	WFRQAPGKAREFVA	36 - 49	14
CDR-H2	AISWSGGDTYADSVKG	50 - 65	16
HFR3	RFTISRDNAKNTVYLQMNSLEPEDTAVYSCAA	66 - 97	32
CDR-H3	VGSKYYISKDAKDYGY	98 - 113	16
HFR4	WGQGTQVTVSS	114 - 124	11
			124

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLQASGGGLVQPGGSLRLPCAAS-----	1 - 25	25
	AbM	EVQLQASGGGLVQPGGSLRLPCAAS-----	1 - 25	25
	Kabat	EVQLQASGGGLVQPGGSLRLPCAASGLIFG	1 - 30	30
	Contact	EVQLQASGGGLVQPGGSLRLPCAASGLIF-	1 - 29	29
	IMGT	EVQLQASGGGLVQPGGSLRLPCAAS-----	1 - 25	25
CDR-H1	Chothia	GLIFGSY---	26 - 32	7
	AbM	GLIFGSYAMG	26 - 35	10
	Kabat	-----SYAMG	31 - 35	5
	Contact	----GSYAMG	30 - 35	6
	IMGT	GLIFGSYA--	26 - 33	8
HFR2	Chothia	AMGWFRQAPGKAREFVAAI	33 - 51	19
	AbM	---WFRQAPGKAREFVA--	36 - 49	14
	Kabat	---WFRQAPGKAREFVA--	36 - 49	14
	Contact	---WFRQAPGKARE-----	36 - 46	11
	IMGT	-MGWFRQAPGKAREFVAA-	34 - 50	17
CDR-H2	Chothia	-----SWSGG---------	52 - 56	5
	AbM	---AISWSGGDT-------	50 - 58	9
	Kabat	---AISWSGGDTYADSVKG	50 - 65	16
	Contact	FVAAISWSGGDT-------	47 - 58	12
	IMGT	----ISWSGGD--------	51 - 57	7
HFR3	Chothia	DTYADSVKGRFTISRDNAKNTVYLQMNSLEPEDTAVYSCAA	57 - 97	41
	AbM	--YADSVKGRFTISRDNAKNTVYLQMNSLEPEDTAVYSCAA	59 - 97	39
	Kabat	---------RFTISRDNAKNTVYLQMNSLEPEDTAVYSCAA	66 - 97	32
	Contact	--YADSVKGRFTISRDNAKNTVYLQMNSLEPEDTAVYSC--	59 - 95	37
	IMGT	-TYADSVKGRFTISRDNAKNTVYLQMNSLEPEDTAVYSC--	58 - 95	38
CDR-H3	Chothia	--VGSKYYISKDAKDYGY	98 - 113	16
	AbM	--VGSKYYISKDAKDYGY	98 - 113	16
	Kabat	--VGSKYYISKDAKDYGY	98 - 113	16
	Contact	AAVGSKYYISKDAKDYG-	96 - 112	17
	IMGT	AAVGSKYYISKDAKDYGY	96 - 113	18
HFR4	Chothia	-WGQGTQVTVSS	114 - 124	11
	AbM	-WGQGTQVTVSS	114 - 124	11
	Kabat	-WGQGTQVTVSS	114 - 124	11
	Contact	YWGQGTQVTVSS	113 - 124	12
	IMGT	-WGQGTQVTVSS	114 - 124	11

Accession & Annotations

Accession	AMK98487.1
Source	abYsis-EMBL-IG KU508541 Submitted 02-MAR-2016 Updated 02-MAR-2016
Name	immunoglobulin heavy chain variable region
Clone	Ad
Organism	Synthetic construct
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Turner K.B., Naciri J., Liu J.L., Anderson G.P., Goldman E.R., Zabetakis D. 'Next-Generation Sequencing of a Single Domain Antibody Repertoire Reveals Quality of Phage Display Selected Candidates' PLoS One 11(2):E0149393-E0149393(2016). Turner K.B., Liu J.L., Anderson G.P., Goldman E.R., Zabetakis D. Submitted (07-JAN-2016) to the INSDC. Center for Bio/Molecular Science and Engineering, US Naval Research Laboratory, 4555 Overlook Ave, Washington, DC 20375, USA

Tools

Sequences

Amino Acid Sequence:

EVQLQASGGGLVQPGGSLRLPCAASGLIFGSYAMGWFRQAPGKAREFVAAISWSGGDTYA
DSVKGRFTISRDNAKNTVYLQMNSLEPEDTAVYSCAAVGSKYYISKDAKDYGYWGQGTQV
TVSS

DNA Sequence:

gaagttcagctgcaggcttctggcggaggcttggttcaaccaggtggtagtctgcgctta
ccgtgtgcagccagcggactgatcttcggctcatatgcgatgggttggtttcgtcaggca
cctggtaaagcgcgcgagtttgtagcggcgattagctggtctggcggcgatacctatgca
gactccgtgaaaggccgtttcaccattagccgcgataatgccaagaacacggtctatctg
cagatgaactcactcgaaccggaagataccgccgtctacagttgcgctgccgtagggtcg
aaatactacatctcgaaagatgcgaaagactatggctattggggtcaagggacacaggtg
actgtgtccagc

Data Source:

Alignment settings:

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