abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLQASGGGLVQAGGSLRLTCAASGRTFG	1 - 30	30
CDR-H1	SYAMG	31 - 35	5
HFR2	WFRQAPGKEREFVA	36 - 49	14
CDR-H2	AISWSGGDTYADSVKG	50 - 65	16
HFR3	RFTISRDNAKNTVYLQMNSLEPEDTAVYWCAA	66 - 97	32
CDR-H3	VRARYYISKVAEDYGY	98 - 113	16
HFR4	WGQGTQVTVSS	114 - 124	11
			124

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLQASGGGLVQAGGSLRLTCAAS-----	1 - 25	25
	AbM	EVQLQASGGGLVQAGGSLRLTCAAS-----	1 - 25	25
	Kabat	EVQLQASGGGLVQAGGSLRLTCAASGRTFG	1 - 30	30
	Contact	EVQLQASGGGLVQAGGSLRLTCAASGRTF-	1 - 29	29
	IMGT	EVQLQASGGGLVQAGGSLRLTCAAS-----	1 - 25	25
CDR-H1	Chothia	GRTFGSY---	26 - 32	7
	AbM	GRTFGSYAMG	26 - 35	10
	Kabat	-----SYAMG	31 - 35	5
	Contact	----GSYAMG	30 - 35	6
	IMGT	GRTFGSYA--	26 - 33	8
HFR2	Chothia	AMGWFRQAPGKEREFVAAI	33 - 51	19
	AbM	---WFRQAPGKEREFVA--	36 - 49	14
	Kabat	---WFRQAPGKEREFVA--	36 - 49	14
	Contact	---WFRQAPGKERE-----	36 - 46	11
	IMGT	-MGWFRQAPGKEREFVAA-	34 - 50	17
CDR-H2	Chothia	-----SWSGG---------	52 - 56	5
	AbM	---AISWSGGDT-------	50 - 58	9
	Kabat	---AISWSGGDTYADSVKG	50 - 65	16
	Contact	FVAAISWSGGDT-------	47 - 58	12
	IMGT	----ISWSGGD--------	51 - 57	7
HFR3	Chothia	DTYADSVKGRFTISRDNAKNTVYLQMNSLEPEDTAVYWCAA	57 - 97	41
	AbM	--YADSVKGRFTISRDNAKNTVYLQMNSLEPEDTAVYWCAA	59 - 97	39
	Kabat	---------RFTISRDNAKNTVYLQMNSLEPEDTAVYWCAA	66 - 97	32
	Contact	--YADSVKGRFTISRDNAKNTVYLQMNSLEPEDTAVYWC--	59 - 95	37
	IMGT	-TYADSVKGRFTISRDNAKNTVYLQMNSLEPEDTAVYWC--	58 - 95	38
CDR-H3	Chothia	--VRARYYISKVAEDYGY	98 - 113	16
	AbM	--VRARYYISKVAEDYGY	98 - 113	16
	Kabat	--VRARYYISKVAEDYGY	98 - 113	16
	Contact	AAVRARYYISKVAEDYG-	96 - 112	17
	IMGT	AAVRARYYISKVAEDYGY	96 - 113	18
HFR4	Chothia	-WGQGTQVTVSS	114 - 124	11
	AbM	-WGQGTQVTVSS	114 - 124	11
	Kabat	-WGQGTQVTVSS	114 - 124	11
	Contact	YWGQGTQVTVSS	113 - 124	12
	IMGT	-WGQGTQVTVSS	114 - 124	11

Accession & Annotations

Accession	AMK98489.1
Source	abYsis-EMBL-IG KU508543 Submitted 02-MAR-2016 Updated 02-MAR-2016
Name	immunoglobulin heavy chain variable region
Clone	Cb
Organism	Synthetic construct
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Turner K.B., Naciri J., Liu J.L., Anderson G.P., Goldman E.R., Zabetakis D. 'Next-Generation Sequencing of a Single Domain Antibody Repertoire Reveals Quality of Phage Display Selected Candidates' PLoS One 11(2):E0149393-E0149393(2016). Turner K.B., Liu J.L., Anderson G.P., Goldman E.R., Zabetakis D. Submitted (07-JAN-2016) to the INSDC. Center for Bio/Molecular Science and Engineering, US Naval Research Laboratory, 4555 Overlook Ave, Washington, DC 20375, USA

Tools

Sequences

Amino Acid Sequence:

EVQLQASGGGLVQAGGSLRLTCAASGRTFGSYAMGWFRQAPGKEREFVAAISWSGGDTYA
DSVKGRFTISRDNAKNTVYLQMNSLEPEDTAVYWCAAVRARYYISKVAEDYGYWGQGTQV
TVSS

DNA Sequence:

gaagtgcagctgcaggcttcaggtggtggtctggtacaagctggtggctcgttacgcctg
acatgcgccgcgtctggtcgtaccttcggcagctatgcgatggggtggtttcgtcaggca
ccagggaaagaacgcgagtttgtagccgcgatttcctggagtggaggcgacacctatgcc
gattctgtcaaaggccgcttcaccatttcccgcgataatgcgaagaacaccgtgtatctc
cagatgaacagcttggaaccggaagatacggccgtgtactggtgtgcggctgttcgtgca
cggtactacatcagcaaagtcgcagaggactatggctattggggccaaggaactcaggtt
acggtgagttcg

Data Source:

Alignment settings:

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