abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVNVVESGGDLVKPGGSLKLSCVASGFTFS	1 - 30	30
CDR-H1	TYGMS	31 - 35	5
HFR2	WVRQTPDKRLEWVA	36 - 49	14
CDR-H2	TVSSGGTHTYYSDSVKG	50 - 66	17
HFR3	RFTISRDNAKNTLYLQMSSLKSEDTATYFCAR	67 - 98	32
CDR-H3	QRDYSPYVDC	99 - 108	10
HFR4	WGQGTTLTVSS	109 - 119	11
			119

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVNVVESGGDLVKPGGSLKLSCVAS-----	1 - 25	25
	AbM	EVNVVESGGDLVKPGGSLKLSCVAS-----	1 - 25	25
	Kabat	EVNVVESGGDLVKPGGSLKLSCVASGFTFS	1 - 30	30
	Contact	EVNVVESGGDLVKPGGSLKLSCVASGFTF-	1 - 29	29
	IMGT	EVNVVESGGDLVKPGGSLKLSCVAS-----	1 - 25	25
CDR-H1	Chothia	GFTFSTY---	26 - 32	7
	AbM	GFTFSTYGMS	26 - 35	10
	Kabat	-----TYGMS	31 - 35	5
	Contact	----STYGMS	30 - 35	6
	IMGT	GFTFSTYG--	26 - 33	8
HFR2	Chothia	GMSWVRQTPDKRLEWVATV	33 - 51	19
	AbM	---WVRQTPDKRLEWVA--	36 - 49	14
	Kabat	---WVRQTPDKRLEWVA--	36 - 49	14
	Contact	---WVRQTPDKRLE-----	36 - 46	11
	IMGT	-MSWVRQTPDKRLEWVAT-	34 - 50	17
CDR-H2	Chothia	-----SSGGTH---------	52 - 57	6
	AbM	---TVSSGGTHTY-------	50 - 59	10
	Kabat	---TVSSGGTHTYYSDSVKG	50 - 66	17
	Contact	WVATVSSGGTHTY-------	47 - 59	13
	IMGT	----VSSGGTHT--------	51 - 58	8
HFR3	Chothia	TYYSDSVKGRFTISRDNAKNTLYLQMSSLKSEDTATYFCAR	58 - 98	41
	AbM	--YSDSVKGRFTISRDNAKNTLYLQMSSLKSEDTATYFCAR	60 - 98	39
	Kabat	---------RFTISRDNAKNTLYLQMSSLKSEDTATYFCAR	67 - 98	32
	Contact	--YSDSVKGRFTISRDNAKNTLYLQMSSLKSEDTATYFC--	60 - 96	37
	IMGT	-YYSDSVKGRFTISRDNAKNTLYLQMSSLKSEDTATYFC--	59 - 96	38
CDR-H3	Chothia	--QRDYSPYVDC	99 - 108	10
	AbM	--QRDYSPYVDC	99 - 108	10
	Kabat	--QRDYSPYVDC	99 - 108	10
	Contact	ARQRDYSPYVD-	97 - 107	11
	IMGT	ARQRDYSPYVDC	97 - 108	12
HFR4	Chothia	-WGQGTTLTVSS	109 - 119	11
	AbM	-WGQGTTLTVSS	109 - 119	11
	Kabat	-WGQGTTLTVSS	109 - 119	11
	Contact	CWGQGTTLTVSS	108 - 119	12
	IMGT	-WGQGTTLTVSS	109 - 119	11

Accession & Annotations

Accession	APU93584.1
Source	abYsis-EMBL-IG KX236315 Submitted 24-JAN-2017 Updated 24-JAN-2017
Name	anti-LMG scFv immunoglobulin heavy chain variable region
Clone	LMG-VH8-2
Organism	Synthetic construct
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Dong J.-X., Li Z.-F., Wang H., Sun Y.-M. Submitted (10-MAY-2016) to the INSDC. Food Science, Guangdong Provincial Key Laboratory of Food Quality and Safety, South China Agricultural University, Wushan Rd, Guangzhou, Guangdong 510642, China Dong J.-X., Li Z.-F., Wang H., Sun Y.-M. 'A universal strategy of single chain variable fragment generation for small chemicals from Hybridomas' Unpublished.

Tools

Sequences

Amino Acid Sequence:

EVNVVESGGDLVKPGGSLKLSCVASGFTFSTYGMSWVRQTPDKRLEWVATVSSGGTHTYY
SDSVKGRFTISRDNAKNTLYLQMSSLKSEDTATYFCARQRDYSPYVDCWGQGTTLTVSS

DNA Sequence:

gaggtgaacgtggtggaatctgggggagacttagtgaagcctggagggtccctgaaactc
tcctgtgtagcctctggattcactttcagtacttatggcatgtcctgggttcgccagact
ccagacaagaggctggagtgggtcgcaaccgttagtagtggtggtactcacacctactat
tcagacagtgtgaaggggcgattcaccatctccagagacaatgccaagaacaccctgtac
ctgcaaatgagcagtctgaagtctgaggacacagccacgtatttctgtgcaagacagagg
gactatagtccctacgtggactgctggggccagggcaccactctcacagtctcctcg

Data Source:

Alignment settings:

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