abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	MGS	1 - 3	3
LFR1	QPVLTQSPSVSAAPRQRVTISV	4 - 25	22
CDR-L1	SGSNSNIGSNTVN	26 - 38	13
LFR2	WIQQLPGRAPELLMY	39 - 53	15
CDR-L2	DDDLLAP	54 - 60	7
LFR3	GVSDRFSGSRSGTSASLTISGLQSEDEADYYA	61 - 92	32
CDR-L3	ATWDDSLNGWV	93 - 103	11
LFR4	FGGGTKVTVLSGH	104 - 116	13
Tail	HHHHH	116 - 121	5
			121

Region	Definition	Sequence Fragment	Residues	Length
LFR1	Chothia	QPVLTQSPSVSAAPRQRVTISV------	4 - 25	22
	AbM	QPVLTQSPSVSAAPRQRVTISV------	4 - 25	22
	Kabat	QPVLTQSPSVSAAPRQRVTISV------	4 - 25	22
	Contact	QPVLTQSPSVSAAPRQRVTISVSGSNSN	4 - 31	28
	IMGT	QPVLTQSPSVSAAPRQRVTISVSGS---	4 - 28	25
CDR-L1	Chothia	SGSNSNIGSNTVN--	26 - 38	13
	AbM	SGSNSNIGSNTVN--	26 - 38	13
	Kabat	SGSNSNIGSNTVN--	26 - 38	13
	Contact	------IGSNTVNWI	32 - 40	9
	IMGT	---NSNIGSNT----	29 - 36	8
LFR2	Chothia	--WIQQLPGRAPELLMY	39 - 53	15
	AbM	--WIQQLPGRAPELLMY	39 - 53	15
	Kabat	--WIQQLPGRAPELLMY	39 - 53	15
	Contact	----QQLPGRAPE----	41 - 49	9
	IMGT	VNWIQQLPGRAPELLMY	37 - 53	17
CDR-L2	Chothia	----DDDLLAP	54 - 60	7
	AbM	----DDDLLAP	54 - 60	7
	Kabat	----DDDLLAP	54 - 60	7
	Contact	LLMYDDDLLA-	50 - 59	10
	IMGT	----DD-----	54 - 55	2
LFR3	Chothia	-----GVSDRFSGSRSGTSASLTISGLQSEDEADYYA	61 - 92	32
	AbM	-----GVSDRFSGSRSGTSASLTISGLQSEDEADYYA	61 - 92	32
	Kabat	-----GVSDRFSGSRSGTSASLTISGLQSEDEADYYA	61 - 92	32
	Contact	----PGVSDRFSGSRSGTSASLTISGLQSEDEADYYA	60 - 92	33
	IMGT	DLLAPGVSDRFSGSRSGTSASLTISGLQSEDEADYYA	56 - 92	37
CDR-L3	Chothia	ATWDDSLNGWV	93 - 103	11
	AbM	ATWDDSLNGWV	93 - 103	11
	Kabat	ATWDDSLNGWV	93 - 103	11
	Contact	ATWDDSLNGW-	93 - 102	10
	IMGT	ATWDDSLNGWV	93 - 103	11
LFR4	Chothia	-FGGGTKVTVLSGH	104 - 116	13
	AbM	-FGGGTKVTVLSGH	104 - 116	13
	Kabat	-FGGGTKVTVLSGH	104 - 116	13
	Contact	VFGGGTKVTVLSGH	103 - 116	14
	IMGT	-FGGGTKVTVLSGH	104 - 116	13

Accession & Annotations

Accession	AVV68404.1
Source	abYsis-EMBL-IG MH107786 Submitted 13-APR-2018 Updated 13-APR-2018
Name	Vl12.1
Organism	Mammalian expression vector pexpr65
Chain Type	Light
Pairing	None
Identical Protein Sequences	abYsis-EMBL-IG: AAV87178.1
References	Siciliano V. Submitted (22-MAR-2018) to the INSDC. Biological Engineering, Massachusetts Institute of Technology, 500 Tech Square, Cambridge, MA 02139, USA Siciliano V. 'Engineering modular intracellular protein sensor-actuator devices' Unpublished.

Tools

Sequences

Amino Acid Sequence:

MGSQPVLTQSPSVSAAPRQRVTISVSGSNSNIGSNTVNWIQQLPGRAPELLMYDDDLLAP
GVSDRFSGSRSGTSASLTISGLQSEDEADYYAATWDDSLNGWVFGGGTKVTVLSGHHHHH
H

DNA Sequence:

ggccaacgcgcggggagaggcggtttgcgtattgggcgctcttccgcttcctcgctcact
gactcgctgcgctcggtcgttcggctgcggcgagcggtatcagctcactcaaaggcggta
atacggttatccacagaatcaggggataacgcaggaaagaacatgtgagcaaaaggccag
caaaaggccaggaaccgtaaaaaggccgcgttgctggcgtttttccataggctccgcccc
cctgacgagcatcacaaaaatcgacgctcaagtcagaggtggcgaaacccgacaggacta
taaagataccaggcgtttccccctggaagctccctcgtgcgctctcctgttccgaccctg
ccgcttaccggatacctgtccgcctttctcccttcgggaagcgtggcgctttctcatagc
tcacgctgtaggtatctcagttcggtgtaggtcgttcgctccaagctgggctgtgtgcac
gaaccccccgttcagcccgaccgctgcgccttatccggtaactatcgtcttgagtccaac
ccggtaagacacgacttatcgccactggcagcagccactggtaacaggattagcagagcg
aggtatgtaggcggtgctacagagttcttgaagtggtggcctaactacggctacactaga
agaacagtatttggtatctgcgctctgctgaagccagttaccttcggaaaaagagttggt
agctcttgatccggcaaacaaaccaccgctggtagcggtggtttttttgtttgcaagcag
cagattacgcgcagaaaaaaaggatctcaagaagatcctttgatcttttctacggggtct
gacgctcagtggaacgaaaactcacgttaagggattttggtcatgagattatcaaaaagg
atcttcacctagatccttttaaattaaaaatgaagttttaaatcaatctaaagtatatat
gagtaaacttggtctgacagttaccaatgcttaatcagtgaggcacctatctcagcgatc
tgtctatttcgttcatccatagttgcctgactccccgtcgtgtagataactacgatacgg
gagggcttaccatctggccccagtgctgcaatgataccgcgagacccacgctcaccggct
ccagatttatcagcaataaaccagccagccggaagggccgagcgcagaagtggtcctgca
actttatccgcctccatccagtctattaattgttgccgggaagctagagtaagtagttcg
ccagttaatagtttgcgcaacgttgttgccattgctacaggcatcgtggtgtcacgctcg
tcgtttggtatggcttcattcagctccggttcccaacgatcaaggcgagttacatgatcc
cccatgttgtgcaaaaaagcggttagctccttcggtcctccgatcgttgtcagaagtaag
ttggccgcagtgttatcactcatggttatggcagcactgcataattctcttactgtcatg
ccatccgtaagatgcttttctgtgactggtgagtactcaaccaagtcattctgagaatag
tgtatgcggcgaccgagttgctcttgcccggcgtcaatacgggataataccgcgccacat
agcagaactttaaaagtgctcatcattggaaaacgttcttcggggcgaaaactctcaagg
atcttaccgctgttgagatccagttcgatgtaacccactcgtgcacccaactgatcttca
gcatcttttactttcaccagcgtttctgggtgagcaaaaacaggaaggcaaaatgccgca
aaaaagggaataagggcgacacggaaatgttgaatactcatactcttcctttttcaatat
tattgaagcatttatcagggttattgtctcatgagcggatacatatttgaatgtatttag
aaaaataaacaaataggggttccgcgcacatttccccgaaaagtgccacctaaattgtaa
gcgttaatattttgttaaaattcgcgttaaatttttgttaaatcagctcattttttaacc
aataggccgaaatcggcaaaatcccttataaatcaaaagaatagaccgagatagggttga
gtgttgttccagtttggaacaagagtccactattaaagaacgtggactccaacgtcaaag
ggcgaaaaaccgtctatcagggcgatggcccactacgtgaaccatcaccctaatcaagtt
ttttggggtcgaggtgccgtaaagcactaaatcggaaccctaaagggagcccccgattta
gagcttgacggggaaagccggcgaacgtggcgagaaaggaagggaagaaagcgaaaggag
cgggcgctagggcgctggcaagtgtagcggtcacgctgcgcgtaaccaccacacccgccg
cgcttaatgcgccgctacagggcgcgtcccattcgccattcaggctgcgcaactgttggg
aagggcgatcggtgcgggcctcttcgctattacgccagctggcgaaagggggatgtgctg
caaggcgattaagttgggtaacgccagggttttcccagtcacgacgttgtaaaacgacgg
ccagtgagcgcgcgtaatacgactcactatagggcgaattgggtacctgctttctctgac
cagcattctctcccctgggcctgtgccgctttctgtctgcagcttgtggcctgggtcacc
tctacggctggcccagatccttccctgccgcctccttcaggttccgtcttcctccactcc
ctcttccccttgctctctgctgtgttgctgcccaaggatgctctttccggagcacttcct
tctcggcgctgcaccacgtgatgtcctctgagcggatcctccccgtgtctgggtcctctc
cgggcatctctcctccctcacccaaccccatgccgtcttcactcgctgggttcccttttc
cttctccttctggggcctgtgccatctctcgtttcttaggatggccttctccgacggatg
tctcccttgcgtcccgcctccccttcttgtaggcctgcatcatcaccgtttttctggaca
accccaaagtaccccgtctccctggctttagccacctctccatcctcttgctttctttgc
ctggacaccccgttctcctgtggattcgggtcacctctcactcctttcatttgggcagct
cccctaccccccttacctctctagtctgtgctagctcttccagccccctgtcatggcatc
ttccaggggtccgagagctcagctagtcttcttcctccaacccgggcccctatgtccact
tcaggacagcatgtttgctgcctccagggatcctgtgtccccgagctgggaccaccttat
attcccagggccggttaatgtggctctggttctgggtacttttatctgtcccctccaccc
cacagtggggcaagcttattaccctgttatccctaaccggtgcgtttttatgcttgtagt
attgtataatgtttttaagatccaagcttctgacctcttctcttcctcccacagggcctc
gagacaattgcatcgatggtaccagtgaaagtctgcaatgaattcgagttggcgcgcctg
tcattctaaatctctctttcagcctaaagctttttccccgtatccccccaggtgtctgca
ggctcaaagagcagcgagaagcgttcagaggaaagcgatcccgtgccaccttccccgtgc
ccgggctgtccccgcacgctgccggctcggggatgcggggggagcgccggaccggagcgg
agccccgggcggctcgctgctgccccctagcgggggagggacgtaattacatccctgggg
gctttgggagggggctgtccccgtgagctcccaggcgcgcctgtcattctaaatctctct
ttcagcctaaagctttttccccgtatccccccaggtgtctgcaggctcaaagagcagcga
gaagcgttcagaggaaagcgatcccgtgccaccttccccgtgcccgggctgtccccgcac
gctgccggctcggggatgcggggggagcgccggaccggagcggagccccgggcggctcgc
tgctgccccctagcgggggagggacgtaattacatccctgggggctttgggggggggctg
tccccgtgagctcccaggcgcgccaactcggtaccgtatcgatgtcgacgttaacgctag
tgatatcaactttgtatagaaaagttggctccgaattcgcccttcaggtccgaggttcta
gacgagtttactccctatcagtgatagagaacgatgtcgagtttactccctatcagtgat
agagaacgtatgtcgagtttactccctatcagtgatagagaacgtatgtcgagtttactc
cctatcagtgatagagaacgtatgtcgagtttatccctatcagtgatagagaacgtatgt
cgagtttactccctatcagtgatagagaacgtatgtcgaggtaggcgtgtacggtgggag
gcctatataagcagagctcgtttagtgaaccgtcagatcgcaaagggcgaattcgaccca
agtttgtacaaaaaagcaggctcgccaccgcggccgcattcgtggccggcctatgagcct
gttcaagggccccagagactacaaccctatcagcagcaccatctgccacctgaccaacga
gagcgacggccacaccaccagcctgtacggcatcggcttcggccccttcatcatcaccaa
caagcacctgttccggcgaaacaacggcaccctgctggtgcagagcctgcacggcgtgtt
caaagtgaagaataccacaaccctgcagcagcacctgatcgacggccgggacatgatcat
catccggatgcccaaggacttcccacccttcccacagaagctgaagttcagagagcccca
gcgcgaggaacggatctgtctggtcacaacaaacttccagaccaagagcatgagcagcat
ggtgtccgataccagctgcaccttccccagcagcgacggcatcttctggaagcactggat
tcagaccaaggacggccagtgcggcagtccactggtgtccacccgggatggcttcatcgt
gggcatccacagcgccagcaacttcaccaacaccaacaactacttcaccagcgtgcccaa
gaacttcatggaactgctgaccaaccaggaagcccagcagtgggtctccggctggcggct
gaacgccgattctgtgctgtggggcggacacaaggtgttcatggtgaagcctgaggaacc
cttccagcccgtgaaagaggccacccagctgatgaacgagctggtgtacagccagggcgg
aggtggatctggcggaggtggatcgggcggaggtggatcaaagcttatgggttctcagcc
tgtgctgactcagtcaccctcggtctctgcagccccccggcaaagggtcaccatctccgt
gtctggaagcaactccaacatcggaagtaatactgtaaactggatccagcagctcccagg
aagggctcccgagctcctcatgtacgatgacgatctattggccccaggggtctctgaccg
attttctggctctaggtctggcacctcagcctccctgaccatcagtgggctccagtctga
ggatgaggctgattattacgcagcaacatgggatgacagcctgaatggttgggtgttcgg
cggagggaccaaggtcaccgtcctatccggacatcaccatcaccatcactgaaccggttg
aacccagctttcttgtacaaagtggtacgcgtgaattcactcctcaggtgcaggctgcct
atcagaaggtggtggctggtgtggccaatgccctggctcacaaataccactgagatcttt
ttccctctgccaaaaattatggggacatcatgaagccccttgagcatctgacttctggct
aataaaggaaatttattttcattgcaatagtgtgttggaattttttgtgtctctcactcg
gaaggacatatgggagggcaaatcatttaaaacatcagaatgagtatttggtttagagtt
tggcaacatatgcccatatgctggctgccatgaacaaaggttggctataaagaggtcatc
agtatatgaaacagccccctgctgtccattccttattccatagaaaagccttgacttgag
gttagattttttttatattttgttttgtgttatttttttctttaacatccctaaaatttt
ccttacatgttttactagccagatttttcctcctctcctgactactcccagtcatagctg
tccctcttctcttatggagatccctcgacctgcagcccaagcttggcgtaatcatggtca
tagctgtttcctgtgtgaaattgttatccgctcacaattccacacaacatacgagccgga
agcataaagtgtaaagcctggggtgcctaatgagtgagctaactcacattaattgcgttg
cgctcactgcccgctttccagtcgggaaacctgtcgtgccagcggatcgacagtactaag
cttggtctaatacccaatctctcgtcttatccagatgttttatacgccttaattaatagg
gataacagggtaatctcgaggtttaaacgtcgacgcggccgctactagggacaggattgg
tgacagaaaagccccatccttaggcctcctccttcctagtctcctgatattgggtctaac
ccccacctcctgttaggcagattccttatctggtgacacacccccatttcctggagccat
ctctctccttgccagaacctctaaggtttgcttacgatggagccagagaggatcctggga
gggagagcttggcagggggtgggagggaagggggggatgcgtgacctgcccggttctcag
tggccaccctgcgctaccctctcccagaacctgagctgctctgacgcggctgtctggtgc
gtttcactgatcctggtgctgcagcttccttacacttcccaagaggagaagcagtttgga
aaaacaaaatcagaataagttggtcctgagttctaactttggctcttcacctttctagtc
cccaatttatattgttcctccgtgcgtcagttttacctgtgagataaggccagtagccag
ccccgtcctggcagggctgtggtgaggaggggggtgtccgtgtggaaaactccctttgtg
agaatggtgcgtcctaggtgttcaccaggtcgtggccgcctctactccctttctctttct
ccatccttctttccttaaagagtccccagtgctatctgggacatattcctccgcccagag
cagggtcccgcttccctaaggccctgctctgggcttctgggtttgagtccttggcaagcc
caggagaggcgctcaggcttccctgtcccccttcctcgtccaccatctcatgcccctggc
tctcctgccccttccctacaggggttcctggctctgctctccaccgcggtggagctccag
cttttgttccctttagtgagggttaattgcgcgcttggcgtaatcatggtcatagctgtt
tcctgtgtgaaattgttatccgctcacaattccacacaacatacgagccggaagcataaa
gtgtaaagcctggggtgcctaatgagtgagctaactcacattaattgcgttgcgctcact
gcccgctttccagtcgggaaacctgtcgtgccagctgcattaatgaatc

Data Source:

Alignment settings:

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