abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQAGGSLRLSCAAAGRNLR	1 - 30	30
CDR-H1	MYRMG	31 - 35	5
HFR2	WFRQAPGKEREFVG	36 - 49	14
CDR-H2	TMVWSSDTIYYADSVKG	50 - 66	17
HFR3	RFIISRDNAKNTVYLQMNSLKPEDTAVYYCAA	67 - 98	32
CDR-H3	GAGWAGTMTDYNY	99 - 111	13
HFR4	WGQGTQVTVSS	112 - 122	11
			122

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQAGGSLRLSCAAA-----	1 - 25	25
	AbM	QVQLQESGGGLVQAGGSLRLSCAAA-----	1 - 25	25
	Kabat	QVQLQESGGGLVQAGGSLRLSCAAAGRNLR	1 - 30	30
	Contact	QVQLQESGGGLVQAGGSLRLSCAAAGRNL-	1 - 29	29
	IMGT	QVQLQESGGGLVQAGGSLRLSCAAA-----	1 - 25	25
CDR-H1	Chothia	GRNLRMY---	26 - 32	7
	AbM	GRNLRMYRMG	26 - 35	10
	Kabat	-----MYRMG	31 - 35	5
	Contact	----RMYRMG	30 - 35	6
	IMGT	GRNLRMYR--	26 - 33	8
HFR2	Chothia	RMGWFRQAPGKEREFVGTM	33 - 51	19
	AbM	---WFRQAPGKEREFVG--	36 - 49	14
	Kabat	---WFRQAPGKEREFVG--	36 - 49	14
	Contact	---WFRQAPGKERE-----	36 - 46	11
	IMGT	-MGWFRQAPGKEREFVGT-	34 - 50	17
CDR-H2	Chothia	-----VWSSDT---------	52 - 57	6
	AbM	---TMVWSSDTIY-------	50 - 59	10
	Kabat	---TMVWSSDTIYYADSVKG	50 - 66	17
	Contact	FVGTMVWSSDTIY-------	47 - 59	13
	IMGT	----MVWSSDTI--------	51 - 58	8
HFR3	Chothia	IYYADSVKGRFIISRDNAKNTVYLQMNSLKPEDTAVYYCAA	58 - 98	41
	AbM	--YADSVKGRFIISRDNAKNTVYLQMNSLKPEDTAVYYCAA	60 - 98	39
	Kabat	---------RFIISRDNAKNTVYLQMNSLKPEDTAVYYCAA	67 - 98	32
	Contact	--YADSVKGRFIISRDNAKNTVYLQMNSLKPEDTAVYYC--	60 - 96	37
	IMGT	-YYADSVKGRFIISRDNAKNTVYLQMNSLKPEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--GAGWAGTMTDYNY	99 - 111	13
	AbM	--GAGWAGTMTDYNY	99 - 111	13
	Kabat	--GAGWAGTMTDYNY	99 - 111	13
	Contact	AAGAGWAGTMTDYN-	97 - 110	14
	IMGT	AAGAGWAGTMTDYNY	97 - 111	15
HFR4	Chothia	-WGQGTQVTVSS	112 - 122	11
	AbM	-WGQGTQVTVSS	112 - 122	11
	Kabat	-WGQGTQVTVSS	112 - 122	11
	Contact	YWGQGTQVTVSS	111 - 122	12
	IMGT	-WGQGTQVTVSS	112 - 122	11

Accession & Annotations

Accession	2x1o_B
Source	PDB 2x1o Submitted 03-JAN-2010 Updated 06-APR-2011
Name	GELSOLIN NANOBODY
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 2x1o_A
References	VAN DEN ABBEELE A., DE CLERCQ S., DE GANCK A., DE CORTE V., VAN LOO B., SOROR H., SRINIVASAN V., STEYAERT J., VANDEKERCKHOVE J., GETTEMANS J. 'A LLAMA-DERIVED GELSOLIN SINGLE-DOMAIN ANTIBODY BLOCKS GELSOLIN-G-ACTIN INTERACTION.' CELL.MOL.LIFE SCI. V. 67 1519 2010 ISSN 1420-682X

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQAGGSLRLSCAAAGRNLRMYRMGWFRQAPGKEREFVGTMVWSSDTIYY
ADSVKGRFIISRDNAKNTVYLQMNSLKPEDTAVYYCAAGAGWAGTMTDYNYWGQGTQVTV
SS