abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQAGGSLRLSCAASGRTFT	1 - 30	30
CDR-H1	SFAMG	31 - 35	5
HFR2	WFRQAPGKEREFVA	36 - 49	14
CDR-H2	SISRSGTLTRYADSAKG	50 - 66	17
HFR3	RFTISVDNAKNTVSLQMDNLNPDDTAVYYCAA	67 - 98	32
CDR-H3	DLHRPYGPGTQRSDEYDS	99 - 116	18
HFR4	WGQGTQVTVSS	117 - 127	11
			127

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGLVQAGGSLRLSCAASGRTFT	1 - 30	30
	Contact	QVQLQESGGGLVQAGGSLRLSCAASGRTF-	1 - 29	29
	IMGT	QVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GRTFTSF---	26 - 32	7
	AbM	GRTFTSFAMG	26 - 35	10
	Kabat	-----SFAMG	31 - 35	5
	Contact	----TSFAMG	30 - 35	6
	IMGT	GRTFTSFA--	26 - 33	8
HFR2	Chothia	AMGWFRQAPGKEREFVASI	33 - 51	19
	AbM	---WFRQAPGKEREFVA--	36 - 49	14
	Kabat	---WFRQAPGKEREFVA--	36 - 49	14
	Contact	---WFRQAPGKERE-----	36 - 46	11
	IMGT	-MGWFRQAPGKEREFVAS-	34 - 50	17
CDR-H2	Chothia	-----SRSGTL---------	52 - 57	6
	AbM	---SISRSGTLTR-------	50 - 59	10
	Kabat	---SISRSGTLTRYADSAKG	50 - 66	17
	Contact	FVASISRSGTLTR-------	47 - 59	13
	IMGT	----ISRSGTLT--------	51 - 58	8
HFR3	Chothia	TRYADSAKGRFTISVDNAKNTVSLQMDNLNPDDTAVYYCAA	58 - 98	41
	AbM	--YADSAKGRFTISVDNAKNTVSLQMDNLNPDDTAVYYCAA	60 - 98	39
	Kabat	---------RFTISVDNAKNTVSLQMDNLNPDDTAVYYCAA	67 - 98	32
	Contact	--YADSAKGRFTISVDNAKNTVSLQMDNLNPDDTAVYYC--	60 - 96	37
	IMGT	-RYADSAKGRFTISVDNAKNTVSLQMDNLNPDDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--DLHRPYGPGTQRSDEYDS	99 - 116	18
	AbM	--DLHRPYGPGTQRSDEYDS	99 - 116	18
	Kabat	--DLHRPYGPGTQRSDEYDS	99 - 116	18
	Contact	AADLHRPYGPGTQRSDEYD-	97 - 115	19
	IMGT	AADLHRPYGPGTQRSDEYDS	97 - 116	20
HFR4	Chothia	-WGQGTQVTVSS	117 - 127	11
	AbM	-WGQGTQVTVSS	117 - 127	11
	Kabat	-WGQGTQVTVSS	117 - 127	11
	Contact	SWGQGTQVTVSS	116 - 127	12
	IMGT	-WGQGTQVTVSS	117 - 127	11

Accession & Annotations

Accession	2x1p_A
Source	PDB 2x1p Submitted 03-JAN-2010 Updated 06-APR-2011
Name	GELSOLIN NANOBODY
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 2x1p_B 2x1p_C 2x1p_D
References	VAN DEN ABBEELE A., DE CLERCQ S., DE GANCK A., DE CORTE V., VAN LOO B., SOROR H., SRINIVASAN V., STEYAERT J., VANDEKERCKHOVE J., GETTEMANS J. 'A LLAMA-DERIVED GELSOLIN SINGLE-DOMAIN ANTIBODY BLOCKS GELSOLIN-G-ACTIN INTERACTION.' CELL.MOL.LIFE SCI. V. 67 1519 2010 ISSN 1420-682X

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQAGGSLRLSCAASGRTFTSFAMGWFRQAPGKEREFVASISRSGTLTRY
ADSAKGRFTISVDNAKNTVSLQMDNLNPDDTAVYYCAADLHRPYGPGTQRSDEYDSWGQG
TQVTVSS