abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQPGGSLRLSCAASGRTFS	1 - 30	30
CDR-H1	NYRMG	31 - 35	5
HFR2	WFRQAPGKEREFVA	36 - 49	14
CDR-H2	TISQSGAATAYADSVKG	50 - 66	17
HFR3	RFTFSRDNAKNLLYLEMLSLEPEDTAVYYCAA	67 - 98	32
CDR-H3	SSRVFYTEVLQTTTGYDY	99 - 116	18
HFR4	WGQGTQVTVSS	117 - 127	11
			127

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGLVQPGGSLRLSCAASGRTFS	1 - 30	30
	Contact	QVQLQESGGGLVQPGGSLRLSCAASGRTF-	1 - 29	29
	IMGT	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GRTFSNY---	26 - 32	7
	AbM	GRTFSNYRMG	26 - 35	10
	Kabat	-----NYRMG	31 - 35	5
	Contact	----SNYRMG	30 - 35	6
	IMGT	GRTFSNYR--	26 - 33	8
HFR2	Chothia	RMGWFRQAPGKEREFVATI	33 - 51	19
	AbM	---WFRQAPGKEREFVA--	36 - 49	14
	Kabat	---WFRQAPGKEREFVA--	36 - 49	14
	Contact	---WFRQAPGKERE-----	36 - 46	11
	IMGT	-MGWFRQAPGKEREFVAT-	34 - 50	17
CDR-H2	Chothia	-----SQSGAA---------	52 - 57	6
	AbM	---TISQSGAATA-------	50 - 59	10
	Kabat	---TISQSGAATAYADSVKG	50 - 66	17
	Contact	FVATISQSGAATA-------	47 - 59	13
	IMGT	----ISQSGAAT--------	51 - 58	8
HFR3	Chothia	TAYADSVKGRFTFSRDNAKNLLYLEMLSLEPEDTAVYYCAA	58 - 98	41
	AbM	--YADSVKGRFTFSRDNAKNLLYLEMLSLEPEDTAVYYCAA	60 - 98	39
	Kabat	---------RFTFSRDNAKNLLYLEMLSLEPEDTAVYYCAA	67 - 98	32
	Contact	--YADSVKGRFTFSRDNAKNLLYLEMLSLEPEDTAVYYC--	60 - 96	37
	IMGT	-AYADSVKGRFTFSRDNAKNLLYLEMLSLEPEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--SSRVFYTEVLQTTTGYDY	99 - 116	18
	AbM	--SSRVFYTEVLQTTTGYDY	99 - 116	18
	Kabat	--SSRVFYTEVLQTTTGYDY	99 - 116	18
	Contact	AASSRVFYTEVLQTTTGYD-	97 - 115	19
	IMGT	AASSRVFYTEVLQTTTGYDY	97 - 116	20
HFR4	Chothia	-WGQGTQVTVSS	117 - 127	11
	AbM	-WGQGTQVTVSS	117 - 127	11
	Kabat	-WGQGTQVTVSS	117 - 127	11
	Contact	YWGQGTQVTVSS	116 - 127	12
	IMGT	-WGQGTQVTVSS	117 - 127	11

Accession & Annotations

Accession	2x1q_B
Source	PDB 2x1q Submitted 03-JAN-2010 Updated 06-APR-2011
Name	GELSOLIN NANOBODY
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 2x1q_A
References	VAN DEN ABBEELE A., DE CLERCQ S., DE GANCK A., DE CORTE V., VAN LOO B., SOROR H., SRINIVASAN V., STEYAERT J., VANDEKERCKHOVE J., GETTEMANS J. 'A LLAMA-DERIVED GELSOLIN SINGLE-DOMAIN ANTIBODY BLOCKS GELSOLIN-G-ACTIN INTERACTION.' CELL.MOL.LIFE SCI. V. 67 1519 2010 ISSN 1420-682X

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQPGGSLRLSCAASGRTFSNYRMGWFRQAPGKEREFVATISQSGAATAY
ADSVKGRFTFSRDNAKNLLYLEMLSLEPEDTAVYYCAASSRVFYTEVLQTTTGYDYWGQG
TQVTVSS