abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGSVQAGGSLRLSCAASGYTDS	1 - 30	30
CDR-H1	RYCMA	31 - 35	5
HFR2	WFRQAPGKEREWVA	36 - 49	14
CDR-H2	RINSGRDITYYADSVKG	50 - 66	17
HFR3	RFTFSQDNAKNTVYLQMDSLEPEDTATYYCAT	67 - 98	32
CDR-H3	DIPLRCRDIVAKGGDGFRY	99 - 117	19
HFR4	WGQGTQVTVSS	118 - 128	11
			128

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGSVQAGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGSVQAGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGSVQAGGSLRLSCAASGYTDS	1 - 30	30
	Contact	QVQLQESGGGSVQAGGSLRLSCAASGYTD-	1 - 29	29
	IMGT	QVQLQESGGGSVQAGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GYTDSRY---	26 - 32	7
	AbM	GYTDSRYCMA	26 - 35	10
	Kabat	-----RYCMA	31 - 35	5
	Contact	----SRYCMA	30 - 35	6
	IMGT	GYTDSRYC--	26 - 33	8
HFR2	Chothia	CMAWFRQAPGKEREWVARI	33 - 51	19
	AbM	---WFRQAPGKEREWVA--	36 - 49	14
	Kabat	---WFRQAPGKEREWVA--	36 - 49	14
	Contact	---WFRQAPGKERE-----	36 - 46	11
	IMGT	-MAWFRQAPGKEREWVAR-	34 - 50	17
CDR-H2	Chothia	-----NSGRDI---------	52 - 57	6
	AbM	---RINSGRDITY-------	50 - 59	10
	Kabat	---RINSGRDITYYADSVKG	50 - 66	17
	Contact	WVARINSGRDITY-------	47 - 59	13
	IMGT	----INSGRDIT--------	51 - 58	8
HFR3	Chothia	TYYADSVKGRFTFSQDNAKNTVYLQMDSLEPEDTATYYCAT	58 - 98	41
	AbM	--YADSVKGRFTFSQDNAKNTVYLQMDSLEPEDTATYYCAT	60 - 98	39
	Kabat	---------RFTFSQDNAKNTVYLQMDSLEPEDTATYYCAT	67 - 98	32
	Contact	--YADSVKGRFTFSQDNAKNTVYLQMDSLEPEDTATYYC--	60 - 96	37
	IMGT	-YYADSVKGRFTFSQDNAKNTVYLQMDSLEPEDTATYYC--	59 - 96	38
CDR-H3	Chothia	--DIPLRCRDIVAKGGDGFRY	99 - 117	19
	AbM	--DIPLRCRDIVAKGGDGFRY	99 - 117	19
	Kabat	--DIPLRCRDIVAKGGDGFRY	99 - 117	19
	Contact	ATDIPLRCRDIVAKGGDGFR-	97 - 116	20
	IMGT	ATDIPLRCRDIVAKGGDGFRY	97 - 117	21
HFR4	Chothia	-WGQGTQVTVSS	118 - 128	11
	AbM	-WGQGTQVTVSS	118 - 128	11
	Kabat	-WGQGTQVTVSS	118 - 128	11
	Contact	YWGQGTQVTVSS	117 - 128	12
	IMGT	-WGQGTQVTVSS	118 - 128	11

Accession & Annotations

Accession	2x89_A
Source	PDB 2x89 Submitted 07-MAR-2010 Updated 04-SEP-2013
Name	STRUCTURE OF THE BETA2_MICROGLOBULIN INVOLVED IN AMYLOIDOGENESIS
Organism	Camelus dromedarius
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 2x89_B 2x89_C
References	DOMANSKA K., VANDERHAEGEN S., SRINIVASAN V., PARDON E., DUPEUX F., MARQUEZ A., GIORGETTI S., STOPPINI M., WYNS L., BELLOTTI V., STEYAERT J. 'ATOMIC STRUCTURE OF A NANOBODY-TRAPPED DOMAIN- SWAPPED DIMER OF AN AMYLOIDOGENIC {BETA}2- MICROGLOBULIN VARIANT.' PROC.NATL.ACAD.SCI.USA V. 108 1314 2011 ISSN 0027-8424

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGSVQAGGSLRLSCAASGYTDSRYCMAWFRQAPGKEREWVARINSGRDITYY
ADSVKGRFTFSQDNAKNTVYLQMDSLEPEDTATYYCATDIPLRCRDIVAKGGDGFRYWGQ
GTQVTVSS