abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QLQESGGGLVQPGGSLRLSCAASGFTFN	1 - 28	28
CDR-H1	NYWMY	29 - 33	5
HFR2	WVRRAPGKGLEWVS	34 - 47	14
CDR-H2	MINPGGIITKYAESVKG	48 - 64	17
HFR3	RFTISRDNAKNTLYLQMNSLTSEDTAVYYCAK	65 - 96	32
CDR-H3	DWATGLAK	97 - 104	8
HFR4	KGQGTQVTVSS	105 - 115	11
			115

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QLQESGGGLVQPGGSLRLSCAAS-----	1 - 23	23
	AbM	QLQESGGGLVQPGGSLRLSCAAS-----	1 - 23	23
	Kabat	QLQESGGGLVQPGGSLRLSCAASGFTFN	1 - 28	28
	Contact	QLQESGGGLVQPGGSLRLSCAASGFTF-	1 - 27	27
	IMGT	QLQESGGGLVQPGGSLRLSCAAS-----	1 - 23	23
CDR-H1	Chothia	GFTFNNY---	24 - 30	7
	AbM	GFTFNNYWMY	24 - 33	10
	Kabat	-----NYWMY	29 - 33	5
	Contact	----NNYWMY	28 - 33	6
	IMGT	GFTFNNYW--	24 - 31	8
HFR2	Chothia	WMYWVRRAPGKGLEWVSMI	31 - 49	19
	AbM	---WVRRAPGKGLEWVS--	34 - 47	14
	Kabat	---WVRRAPGKGLEWVS--	34 - 47	14
	Contact	---WVRRAPGKGLE-----	34 - 44	11
	IMGT	-MYWVRRAPGKGLEWVSM-	32 - 48	17
CDR-H2	Chothia	-----NPGGII---------	50 - 55	6
	AbM	---MINPGGIITK-------	48 - 57	10
	Kabat	---MINPGGIITKYAESVKG	48 - 64	17
	Contact	WVSMINPGGIITK-------	45 - 57	13
	IMGT	----INPGGIIT--------	49 - 56	8
HFR3	Chothia	TKYAESVKGRFTISRDNAKNTLYLQMNSLTSEDTAVYYCAK	56 - 96	41
	AbM	--YAESVKGRFTISRDNAKNTLYLQMNSLTSEDTAVYYCAK	58 - 96	39
	Kabat	---------RFTISRDNAKNTLYLQMNSLTSEDTAVYYCAK	65 - 96	32
	Contact	--YAESVKGRFTISRDNAKNTLYLQMNSLTSEDTAVYYC--	58 - 94	37
	IMGT	-KYAESVKGRFTISRDNAKNTLYLQMNSLTSEDTAVYYC--	57 - 94	38
CDR-H3	Chothia	--DWATGLAK	97 - 104	8
	AbM	--DWATGLAK	97 - 104	8
	Kabat	--DWATGLAK	97 - 104	8
	Contact	AKDWATGLA-	95 - 103	9
	IMGT	AKDWATGLAK	95 - 104	10
HFR4	Chothia	-KGQGTQVTVSS	105 - 115	11
	AbM	-KGQGTQVTVSS	105 - 115	11
	Kabat	-KGQGTQVTVSS	105 - 115	11
	Contact	KKGQGTQVTVSS	104 - 115	12
	IMGT	-KGQGTQVTVSS	105 - 115	11

Accession & Annotations

Accession	3k74_B
Source	PDB 3k74 Submitted 12-OCT-2009 Updated 01-NOV-2017
Name	DISRUPTION OF PROTEIN DYNAMICS BY AN ALLOSTERIC EFFECTOR ANTIBODY
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	OYEN D., SRINIVASAN V., STEYAERT J., BARLOW N. 'CONSTRAINING ENZYME CONFORMATIONAL CHANGE BY AN ANTIBODY LEADS TO HYPERBOLIC INHIBITION.' J.MOL.BIOL. V. 407 138 2011 ISSN 0022-2836

Tools

Sequences

Amino Acid Sequence:

QLQESGGGLVQPGGSLRLSCAASGFTFNNYWMYWVRRAPGKGLEWVSMINPGGIITKYAE
SVKGRFTISRDNAKNTLYLQMNSLTSEDTAVYYCAKDWATGLAKKGQGTQVTVSS