abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQAGGSLRLSCAASGSIFS	1 - 30	30
CDR-H1	INTMG	31 - 35	5
HFR2	WYRQAPGKQRELVA	36 - 49	14
CDR-H2	AIHSGGSTNYANSVKG	50 - 65	16
HFR3	RFTISRDNAANTVYLQMNSLKPEDTAVYYCNV	66 - 97	32
CDR-H3	KDYGAVLYEYDY	98 - 109	12
HFR4	WGQGTQVTVSS	110 - 120	11
Tail	HHHHHH	120 - 126	6
			126

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGLVQAGGSLRLSCAASGSIFS	1 - 30	30
	Contact	QVQLQESGGGLVQAGGSLRLSCAASGSIF-	1 - 29	29
	IMGT	QVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GSIFSIN---	26 - 32	7
	AbM	GSIFSINTMG	26 - 35	10
	Kabat	-----INTMG	31 - 35	5
	Contact	----SINTMG	30 - 35	6
	IMGT	GSIFSINT--	26 - 33	8
HFR2	Chothia	TMGWYRQAPGKQRELVAAI	33 - 51	19
	AbM	---WYRQAPGKQRELVA--	36 - 49	14
	Kabat	---WYRQAPGKQRELVA--	36 - 49	14
	Contact	---WYRQAPGKQRE-----	36 - 46	11
	IMGT	-MGWYRQAPGKQRELVAA-	34 - 50	17
CDR-H2	Chothia	-----HSGGS---------	52 - 56	5
	AbM	---AIHSGGSTN-------	50 - 58	9
	Kabat	---AIHSGGSTNYANSVKG	50 - 65	16
	Contact	LVAAIHSGGSTN-------	47 - 58	12
	IMGT	----IHSGGST--------	51 - 57	7
HFR3	Chothia	TNYANSVKGRFTISRDNAANTVYLQMNSLKPEDTAVYYCNV	57 - 97	41
	AbM	--YANSVKGRFTISRDNAANTVYLQMNSLKPEDTAVYYCNV	59 - 97	39
	Kabat	---------RFTISRDNAANTVYLQMNSLKPEDTAVYYCNV	66 - 97	32
	Contact	--YANSVKGRFTISRDNAANTVYLQMNSLKPEDTAVYYC--	59 - 95	37
	IMGT	-NYANSVKGRFTISRDNAANTVYLQMNSLKPEDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--KDYGAVLYEYDY	98 - 109	12
	AbM	--KDYGAVLYEYDY	98 - 109	12
	Kabat	--KDYGAVLYEYDY	98 - 109	12
	Contact	NVKDYGAVLYEYD-	96 - 108	13
	IMGT	NVKDYGAVLYEYDY	96 - 109	14
HFR4	Chothia	-WGQGTQVTVSS	110 - 120	11
	AbM	-WGQGTQVTVSS	110 - 120	11
	Kabat	-WGQGTQVTVSS	110 - 120	11
	Contact	YWGQGTQVTVSS	109 - 120	12
	IMGT	-WGQGTQVTVSS	110 - 120	11

Accession & Annotations

Accession	3p0g_B
Source	PDB 3p0g Submitted 28-SEP-2010 Updated 08-NOV-2017
Name	STRUCTURE OF A NANOBODY-STABILIZED ACTIVE STATE OF THE BETA2 ADRENOCEPTOR
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	RASMUSSEN G., CHOI J., FUNG J., PARDON E., CASAROSA P., CHAE S., DEVREE T., ROSENBAUM M., THIAN S., KOBILKA S., SCHNAPP A., KONETZKI I., SUNAHARA K., GELLMAN H., PAUTSCH A., STEYAERT J., WEIS I., KOBILKA K. 'STRUCTURE OF A NANOBODY-STABILIZED ACTIVE STATE OF THE B2 ADRENOCEPTOR' NATURE V. 469 175 2011 ISSN 0028-0836

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQAGGSLRLSCAASGSIFSINTMGWYRQAPGKQRELVAAIHSGGSTNYA
NSVKGRFTISRDNAANTVYLQMNSLKPEDTAVYYCNVKDYGAVLYEYDYWGQGTQVTVSS
HHHHHH