abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQPGGSLRLSCSASGFKFN	1 - 30	30
CDR-H1	DSYMS	31 - 35	5
HFR2	WVRRVPGKGLEWVA	36 - 49	14
CDR-H2	GIWEDSSAAHYRDSVKG	50 - 66	17
HFR3	RFTISRDNAKNMLYLQMSSLKSDDTGLYYCVR	67 - 98	32
CDR-H3	RGYSGDYRPINNP	99 - 111	13
HFR4	SSQGTQVTVSS	112 - 122	11
Tail	AAAYPYDVPDYGSHHHHHH	122 - 141	19
			141

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQPGGSLRLSCSAS-----	1 - 25	25
	AbM	QVQLQESGGGLVQPGGSLRLSCSAS-----	1 - 25	25
	Kabat	QVQLQESGGGLVQPGGSLRLSCSASGFKFN	1 - 30	30
	Contact	QVQLQESGGGLVQPGGSLRLSCSASGFKF-	1 - 29	29
	IMGT	QVQLQESGGGLVQPGGSLRLSCSAS-----	1 - 25	25
CDR-H1	Chothia	GFKFNDS---	26 - 32	7
	AbM	GFKFNDSYMS	26 - 35	10
	Kabat	-----DSYMS	31 - 35	5
	Contact	----NDSYMS	30 - 35	6
	IMGT	GFKFNDSY--	26 - 33	8
HFR2	Chothia	YMSWVRRVPGKGLEWVAGI	33 - 51	19
	AbM	---WVRRVPGKGLEWVA--	36 - 49	14
	Kabat	---WVRRVPGKGLEWVA--	36 - 49	14
	Contact	---WVRRVPGKGLE-----	36 - 46	11
	IMGT	-MSWVRRVPGKGLEWVAG-	34 - 50	17
CDR-H2	Chothia	-----WEDSSA---------	52 - 57	6
	AbM	---GIWEDSSAAH-------	50 - 59	10
	Kabat	---GIWEDSSAAHYRDSVKG	50 - 66	17
	Contact	WVAGIWEDSSAAH-------	47 - 59	13
	IMGT	----IWEDSSAA--------	51 - 58	8
HFR3	Chothia	AHYRDSVKGRFTISRDNAKNMLYLQMSSLKSDDTGLYYCVR	58 - 98	41
	AbM	--YRDSVKGRFTISRDNAKNMLYLQMSSLKSDDTGLYYCVR	60 - 98	39
	Kabat	---------RFTISRDNAKNMLYLQMSSLKSDDTGLYYCVR	67 - 98	32
	Contact	--YRDSVKGRFTISRDNAKNMLYLQMSSLKSDDTGLYYC--	60 - 96	37
	IMGT	-HYRDSVKGRFTISRDNAKNMLYLQMSSLKSDDTGLYYC--	59 - 96	38
CDR-H3	Chothia	--RGYSGDYRPINNP	99 - 111	13
	AbM	--RGYSGDYRPINNP	99 - 111	13
	Kabat	--RGYSGDYRPINNP	99 - 111	13
	Contact	VRRGYSGDYRPINN-	97 - 110	14
	IMGT	VRRGYSGDYRPINNP	97 - 111	15
HFR4	Chothia	-SSQGTQVTVSS	112 - 122	11
	AbM	-SSQGTQVTVSS	112 - 122	11
	Kabat	-SSQGTQVTVSS	112 - 122	11
	Contact	PSSQGTQVTVSS	111 - 122	12
	IMGT	-SSQGTQVTVSS	112 - 122	11

Accession & Annotations

Accession	4c57_D
Source	PDB 4c57 Submitted 10-SEP-2013 Updated 20-FEB-2019
Name	STRUCTURE OF GAK KINASE IN COMPLEX WITH A NANOBODY
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 4c57_C
References	CHAIKUAD A., KEATES T., VINCKE C., KAUFHOLZ M., ZENN M., ZIMMERMANN B., GUTIERREZ C., ZHANG R., HATZOS-SKINTGES C., JOACHIMIAK A., MUYLDERMANS S., HERBERG W., KNAPP S., MULLER S. 'STRUCTURE OF CYCLIN G-ASSOCIATED KINASE (GAK) TRAPPED IN DIFFERENT CONFORMATIONS USING NANOBODIES.' BIOCHEM.J. V. 459 59 2014 ISSN 0264-6021

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQPGGSLRLSCSASGFKFNDSYMSWVRRVPGKGLEWVAGIWEDSSAAHY
RDSVKGRFTISRDNAKNMLYLQMSSLKSDDTGLYYCVRRGYSGDYRPINNPSSQGTQVTV
SSAAAYPYDVPDYGSHHHHHH