abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	MKYLLPTAAAGLLLLAAQPAMA	1 - 22	22
HFR1	QVQLQESGGGLVQAGGSLRLSCAASGIWFS	23 - 52	30
CDR-H1	INNMA	53 - 57	5
HFR2	WYRQTPGKQRERIA	58 - 71	14
CDR-H2	IITSAGTTNYVDSVKG	72 - 87	16
HFR3	RFTISRDDAKNTMYLQMNSLIPEDTAVYYCNL	88 - 119	32
CDR-H3	VADYDMGFQSF	120 - 130	11
HFR4	WGRGTQVTVSS	131 - 141	11
Tail	HHHHHH	141 - 147	6
			147

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQAGGSLRLSCAAS-----	23 - 47	25
	AbM	QVQLQESGGGLVQAGGSLRLSCAAS-----	23 - 47	25
	Kabat	QVQLQESGGGLVQAGGSLRLSCAASGIWFS	23 - 52	30
	Contact	QVQLQESGGGLVQAGGSLRLSCAASGIWF-	23 - 51	29
	IMGT	QVQLQESGGGLVQAGGSLRLSCAAS-----	23 - 47	25
CDR-H1	Chothia	GIWFSIN---	48 - 54	7
	AbM	GIWFSINNMA	48 - 57	10
	Kabat	-----INNMA	53 - 57	5
	Contact	----SINNMA	52 - 57	6
	IMGT	GIWFSINN--	48 - 55	8
HFR2	Chothia	NMAWYRQTPGKQRERIAII	55 - 73	19
	AbM	---WYRQTPGKQRERIA--	58 - 71	14
	Kabat	---WYRQTPGKQRERIA--	58 - 71	14
	Contact	---WYRQTPGKQRE-----	58 - 68	11
	IMGT	-MAWYRQTPGKQRERIAI-	56 - 72	17
CDR-H2	Chothia	-----TSAGT---------	74 - 78	5
	AbM	---IITSAGTTN-------	72 - 80	9
	Kabat	---IITSAGTTNYVDSVKG	72 - 87	16
	Contact	RIAIITSAGTTN-------	69 - 80	12
	IMGT	----ITSAGTT--------	73 - 79	7
HFR3	Chothia	TNYVDSVKGRFTISRDDAKNTMYLQMNSLIPEDTAVYYCNL	79 - 119	41
	AbM	--YVDSVKGRFTISRDDAKNTMYLQMNSLIPEDTAVYYCNL	81 - 119	39
	Kabat	---------RFTISRDDAKNTMYLQMNSLIPEDTAVYYCNL	88 - 119	32
	Contact	--YVDSVKGRFTISRDDAKNTMYLQMNSLIPEDTAVYYC--	81 - 117	37
	IMGT	-NYVDSVKGRFTISRDDAKNTMYLQMNSLIPEDTAVYYC--	80 - 117	38
CDR-H3	Chothia	--VADYDMGFQSF	120 - 130	11
	AbM	--VADYDMGFQSF	120 - 130	11
	Kabat	--VADYDMGFQSF	120 - 130	11
	Contact	NLVADYDMGFQS-	118 - 129	12
	IMGT	NLVADYDMGFQSF	118 - 130	13
HFR4	Chothia	-WGRGTQVTVSS	131 - 141	11
	AbM	-WGRGTQVTVSS	131 - 141	11
	Kabat	-WGRGTQVTVSS	131 - 141	11
	Contact	FWGRGTQVTVSS	130 - 141	12
	IMGT	-WGRGTQVTVSS	131 - 141	11

Accession & Annotations

Accession	4cdg_D
Source	PDB 4cdg Submitted 31-OCT-2013 Updated 24-JAN-2018
Name	CRYSTAL STRUCTURE OF THE BLOOM'S SYNDROME HELICASE BLM IN COMPLEX WITH NANOBODY
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 4cdg_C
References	NEWMAN A., SAVITSKY P., ALLERSTON K., BIZARD H., OZER O., SARLOS K., LIU Y., PARDON E., STEYAERT J., HICKSON D., GILEADI O. 'CRYSTAL STRUCTURE OF THE BLOOM'S SYNDROME HELICASE INDICATES A ROLE FOR THE HRDC DOMAIN IN CONFORMATIONAL CHANGES.' NUCLEIC ACIDS RES. V. 43 5221 2015 ISSN 0305-1048

Tools

Sequences

Amino Acid Sequence:

MKYLLPTAAAGLLLLAAQPAMAQVQLQESGGGLVQAGGSLRLSCAASGIWFSINNMAWYR
QTPGKQRERIAIITSAGTTNYVDSVKGRFTISRDDAKNTMYLQMNSLIPEDTAVYYCNLV
ADYDMGFQSFWGRGTQVTVSSHHHHHH