abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQAGGSLRLSCKASGIIFS	1 - 30	30
CDR-H1	VYKMT	31 - 35	5
HFR2	WYRQAPGKERELVA	36 - 49	14
CDR-H2	LITTNNNTMTVDSVKG	50 - 65	16
HFR3	RFTISRDNVQNTVYLEMNNLKPEDTAVYYCNA	66 - 97	32
CDR-H3	NRGLAGPAY	98 - 106	9
HFR4	WGQGTQVTVSS	107 - 117	11
Tail	HHHHHH	117 - 123	6
			123

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQAGGSLRLSCKAS-----	1 - 25	25
	AbM	QVQLQESGGGLVQAGGSLRLSCKAS-----	1 - 25	25
	Kabat	QVQLQESGGGLVQAGGSLRLSCKASGIIFS	1 - 30	30
	Contact	QVQLQESGGGLVQAGGSLRLSCKASGIIF-	1 - 29	29
	IMGT	QVQLQESGGGLVQAGGSLRLSCKAS-----	1 - 25	25
CDR-H1	Chothia	GIIFSVY---	26 - 32	7
	AbM	GIIFSVYKMT	26 - 35	10
	Kabat	-----VYKMT	31 - 35	5
	Contact	----SVYKMT	30 - 35	6
	IMGT	GIIFSVYK--	26 - 33	8
HFR2	Chothia	KMTWYRQAPGKERELVALI	33 - 51	19
	AbM	---WYRQAPGKERELVA--	36 - 49	14
	Kabat	---WYRQAPGKERELVA--	36 - 49	14
	Contact	---WYRQAPGKERE-----	36 - 46	11
	IMGT	-MTWYRQAPGKERELVAL-	34 - 50	17
CDR-H2	Chothia	-----TTNNN---------	52 - 56	5
	AbM	---LITTNNNTM-------	50 - 58	9
	Kabat	---LITTNNNTMTVDSVKG	50 - 65	16
	Contact	LVALITTNNNTM-------	47 - 58	12
	IMGT	----ITTNNNT--------	51 - 57	7
HFR3	Chothia	TMTVDSVKGRFTISRDNVQNTVYLEMNNLKPEDTAVYYCNA	57 - 97	41
	AbM	--TVDSVKGRFTISRDNVQNTVYLEMNNLKPEDTAVYYCNA	59 - 97	39
	Kabat	---------RFTISRDNVQNTVYLEMNNLKPEDTAVYYCNA	66 - 97	32
	Contact	--TVDSVKGRFTISRDNVQNTVYLEMNNLKPEDTAVYYC--	59 - 95	37
	IMGT	-MTVDSVKGRFTISRDNVQNTVYLEMNNLKPEDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--NRGLAGPAY	98 - 106	9
	AbM	--NRGLAGPAY	98 - 106	9
	Kabat	--NRGLAGPAY	98 - 106	9
	Contact	NANRGLAGPA-	96 - 105	10
	IMGT	NANRGLAGPAY	96 - 106	11
HFR4	Chothia	-WGQGTQVTVSS	107 - 117	11
	AbM	-WGQGTQVTVSS	107 - 117	11
	Kabat	-WGQGTQVTVSS	107 - 117	11
	Contact	YWGQGTQVTVSS	106 - 117	12
	IMGT	-WGQGTQVTVSS	107 - 117	11

Accession & Annotations

Accession	4eig_B
Source	PDB 4eig Submitted 05-APR-2012 Updated 15-NOV-2017
Name	CA1698 CAMEL ANTIBODY FRAGMENT IN COMPLEX WITH DHFR
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	OYEN D., WECHSELBERGER R., SRINIVASAN V., STEYAERT J., BARLOW N. 'MECHANISTIC ANALYSIS OF ALLOSTERIC AND NON-ALLOSTERIC EFFECTS ARISING FROM NANOBODY BINDING TO TWO EPITOPES OF THE DIHYROFOLATE REDUCTASE OF ESCHERICHIA COLI.' BIOCHIM.BIOPHYS.ACTA V.1834 2147 2013 ISSN 0006-3002

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQAGGSLRLSCKASGIIFSVYKMTWYRQAPGKERELVALITTNNNTMTV
DSVKGRFTISRDNVQNTVYLEMNNLKPEDTAVYYCNANRGLAGPAYWGQGTQVTVSSHHH
HHH