abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLVESGGGLVQAGGSLRLSCAASGRTFS	1 - 30	30
CDR-H1	WSAVG	31 - 35	5
HFR2	WFRQAPGKEREFVA	36 - 49	14
CDR-H2	AIRWSGGSPYYADSVKD	50 - 66	17
HFR3	RFTISRDNAKNTVYLQMNSLRPEDTAVYLCGE	67 - 98	32
CDR-H3	TSLFPTSRGSHYDT	99 - 112	14
HFR4	WGQGTQVTVSS	113 - 123	11
			123

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	AbM	EVQLVESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	Kabat	EVQLVESGGGLVQAGGSLRLSCAASGRTFS	1 - 30	30
	Contact	EVQLVESGGGLVQAGGSLRLSCAASGRTF-	1 - 29	29
	IMGT	EVQLVESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GRTFSWS---	26 - 32	7
	AbM	GRTFSWSAVG	26 - 35	10
	Kabat	-----WSAVG	31 - 35	5
	Contact	----SWSAVG	30 - 35	6
	IMGT	GRTFSWSA--	26 - 33	8
HFR2	Chothia	AVGWFRQAPGKEREFVAAI	33 - 51	19
	AbM	---WFRQAPGKEREFVA--	36 - 49	14
	Kabat	---WFRQAPGKEREFVA--	36 - 49	14
	Contact	---WFRQAPGKERE-----	36 - 46	11
	IMGT	-VGWFRQAPGKEREFVAA-	34 - 50	17
CDR-H2	Chothia	-----RWSGGS---------	52 - 57	6
	AbM	---AIRWSGGSPY-------	50 - 59	10
	Kabat	---AIRWSGGSPYYADSVKD	50 - 66	17
	Contact	FVAAIRWSGGSPY-------	47 - 59	13
	IMGT	----IRWSGGSP--------	51 - 58	8
HFR3	Chothia	PYYADSVKDRFTISRDNAKNTVYLQMNSLRPEDTAVYLCGE	58 - 98	41
	AbM	--YADSVKDRFTISRDNAKNTVYLQMNSLRPEDTAVYLCGE	60 - 98	39
	Kabat	---------RFTISRDNAKNTVYLQMNSLRPEDTAVYLCGE	67 - 98	32
	Contact	--YADSVKDRFTISRDNAKNTVYLQMNSLRPEDTAVYLC--	60 - 96	37
	IMGT	-YYADSVKDRFTISRDNAKNTVYLQMNSLRPEDTAVYLC--	59 - 96	38
CDR-H3	Chothia	--TSLFPTSRGSHYDT	99 - 112	14
	AbM	--TSLFPTSRGSHYDT	99 - 112	14
	Kabat	--TSLFPTSRGSHYDT	99 - 112	14
	Contact	GETSLFPTSRGSHYD-	97 - 111	15
	IMGT	GETSLFPTSRGSHYDT	97 - 112	16
HFR4	Chothia	-WGQGTQVTVSS	113 - 123	11
	AbM	-WGQGTQVTVSS	113 - 123	11
	Kabat	-WGQGTQVTVSS	113 - 123	11
	Contact	TWGQGTQVTVSS	112 - 123	12
	IMGT	-WGQGTQVTVSS	113 - 123	11

Accession & Annotations

Accession	4grw_H
Source	PDB 4grw Submitted 27-AUG-2012 Updated 06-DEC-2017
Name	STRUCTURE OF A COMPLEX OF HUMAN IL-23 WITH 3 NANOBODIES (LLAMA VHHS)
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 4grw_I
References	DESMYTER A., SPINELLI S., BOUTTON C., SAUNDERS M., BLACHETOT C., DE HAARD H., DENECKER G., VAN ROY M., CAMBILLAU C., ROMMELAERE H. 'NEUTRALIZATION OF HUMAN INTERLEUKIN 23 BY MULTIVALENT NANOBODIES EXPLAINED BY THE STRUCTURE OF CYTOKINE-NANOBODY COMPLEX.' FRONT IMMUNOL V. 8 884 2017 ESSN 1664-3224

Tools

Sequences

Amino Acid Sequence:

EVQLVESGGGLVQAGGSLRLSCAASGRTFSWSAVGWFRQAPGKEREFVAAIRWSGGSPYY
ADSVKDRFTISRDNAKNTVYLQMNSLRPEDTAVYLCGETSLFPTSRGSHYDTWGQGTQVT
VSS