abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLVESGGGLVQPGGSLRLSCAASGFTLD	1 - 30	30
CDR-H1	YLAIG	31 - 35	5
HFR2	WFRQAPGKEREGVS	36 - 49	14
CDR-H2	CVSSSGQYTYYADSVKG	50 - 66	17
HFR3	RFTISRDNAESTVYLQMNSLKPEDTAVYYCAT	67 - 98	32
CDR-H3	DPECYRVRGYYNGEYDY	99 - 115	17
HFR4	WGQGTQVTVSS	116 - 126	11
			126

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	AbM	EVQLVESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	Kabat	EVQLVESGGGLVQPGGSLRLSCAASGFTLD	1 - 30	30
	Contact	EVQLVESGGGLVQPGGSLRLSCAASGFTL-	1 - 29	29
	IMGT	EVQLVESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GFTLDYL---	26 - 32	7
	AbM	GFTLDYLAIG	26 - 35	10
	Kabat	-----YLAIG	31 - 35	5
	Contact	----DYLAIG	30 - 35	6
	IMGT	GFTLDYLA--	26 - 33	8
HFR2	Chothia	AIGWFRQAPGKEREGVSCV	33 - 51	19
	AbM	---WFRQAPGKEREGVS--	36 - 49	14
	Kabat	---WFRQAPGKEREGVS--	36 - 49	14
	Contact	---WFRQAPGKERE-----	36 - 46	11
	IMGT	-IGWFRQAPGKEREGVSC-	34 - 50	17
CDR-H2	Chothia	-----SSSGQY---------	52 - 57	6
	AbM	---CVSSSGQYTY-------	50 - 59	10
	Kabat	---CVSSSGQYTYYADSVKG	50 - 66	17
	Contact	GVSCVSSSGQYTY-------	47 - 59	13
	IMGT	----VSSSGQYT--------	51 - 58	8
HFR3	Chothia	TYYADSVKGRFTISRDNAESTVYLQMNSLKPEDTAVYYCAT	58 - 98	41
	AbM	--YADSVKGRFTISRDNAESTVYLQMNSLKPEDTAVYYCAT	60 - 98	39
	Kabat	---------RFTISRDNAESTVYLQMNSLKPEDTAVYYCAT	67 - 98	32
	Contact	--YADSVKGRFTISRDNAESTVYLQMNSLKPEDTAVYYC--	60 - 96	37
	IMGT	-YYADSVKGRFTISRDNAESTVYLQMNSLKPEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--DPECYRVRGYYNGEYDY	99 - 115	17
	AbM	--DPECYRVRGYYNGEYDY	99 - 115	17
	Kabat	--DPECYRVRGYYNGEYDY	99 - 115	17
	Contact	ATDPECYRVRGYYNGEYD-	97 - 114	18
	IMGT	ATDPECYRVRGYYNGEYDY	97 - 115	19
HFR4	Chothia	-WGQGTQVTVSS	116 - 126	11
	AbM	-WGQGTQVTVSS	116 - 126	11
	Kabat	-WGQGTQVTVSS	116 - 126	11
	Contact	YWGQGTQVTVSS	115 - 126	12
	IMGT	-WGQGTQVTVSS	116 - 126	11

Accession & Annotations

Accession	4grw_J
Source	PDB 4grw Submitted 27-AUG-2012 Updated 06-DEC-2017
Name	STRUCTURE OF A COMPLEX OF HUMAN IL-23 WITH 3 NANOBODIES (LLAMA VHHS)
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 4grw_F
References	DESMYTER A., SPINELLI S., BOUTTON C., SAUNDERS M., BLACHETOT C., DE HAARD H., DENECKER G., VAN ROY M., CAMBILLAU C., ROMMELAERE H. 'NEUTRALIZATION OF HUMAN INTERLEUKIN 23 BY MULTIVALENT NANOBODIES EXPLAINED BY THE STRUCTURE OF CYTOKINE-NANOBODY COMPLEX.' FRONT IMMUNOL V. 8 884 2017 ESSN 1664-3224

Tools

Sequences

Amino Acid Sequence:

EVQLVESGGGLVQPGGSLRLSCAASGFTLDYLAIGWFRQAPGKEREGVSCVSSSGQYTYY
ADSVKGRFTISRDNAESTVYLQMNSLKPEDTAVYYCATDPECYRVRGYYNGEYDYWGQGT
QVTVSS