abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQAGASLRLSCAASERLTV	1 - 30	30
CDR-H1	DYAIG	31 - 35	5
HFR2	WFRQAPGKEREFVA	36 - 49	14
CDR-H2	AISWGGGLTVYGESVEG	50 - 66	17
HFR3	RFTISRDIAKNTMNLQMNVLRPEDTANYYCAA	67 - 98	32
CDR-H3	SRISYAVWNTIPYNKLTL	99 - 116	18
HFR4	WGRGTQVTVSS	117 - 127	11
Tail	HHHHHH	127 - 133	6
			133

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQAGASLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGLVQAGASLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGLVQAGASLRLSCAASERLTV	1 - 30	30
	Contact	QVQLQESGGGLVQAGASLRLSCAASERLT-	1 - 29	29
	IMGT	QVQLQESGGGLVQAGASLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	ERLTVDY---	26 - 32	7
	AbM	ERLTVDYAIG	26 - 35	10
	Kabat	-----DYAIG	31 - 35	5
	Contact	----VDYAIG	30 - 35	6
	IMGT	ERLTVDYA--	26 - 33	8
HFR2	Chothia	AIGWFRQAPGKEREFVAAI	33 - 51	19
	AbM	---WFRQAPGKEREFVA--	36 - 49	14
	Kabat	---WFRQAPGKEREFVA--	36 - 49	14
	Contact	---WFRQAPGKERE-----	36 - 46	11
	IMGT	-IGWFRQAPGKEREFVAA-	34 - 50	17
CDR-H2	Chothia	-----SWGGGL---------	52 - 57	6
	AbM	---AISWGGGLTV-------	50 - 59	10
	Kabat	---AISWGGGLTVYGESVEG	50 - 66	17
	Contact	FVAAISWGGGLTV-------	47 - 59	13
	IMGT	----ISWGGGLT--------	51 - 58	8
HFR3	Chothia	TVYGESVEGRFTISRDIAKNTMNLQMNVLRPEDTANYYCAA	58 - 98	41
	AbM	--YGESVEGRFTISRDIAKNTMNLQMNVLRPEDTANYYCAA	60 - 98	39
	Kabat	---------RFTISRDIAKNTMNLQMNVLRPEDTANYYCAA	67 - 98	32
	Contact	--YGESVEGRFTISRDIAKNTMNLQMNVLRPEDTANYYC--	60 - 96	37
	IMGT	-VYGESVEGRFTISRDIAKNTMNLQMNVLRPEDTANYYC--	59 - 96	38
CDR-H3	Chothia	--SRISYAVWNTIPYNKLTL	99 - 116	18
	AbM	--SRISYAVWNTIPYNKLTL	99 - 116	18
	Kabat	--SRISYAVWNTIPYNKLTL	99 - 116	18
	Contact	AASRISYAVWNTIPYNKLT-	97 - 115	19
	IMGT	AASRISYAVWNTIPYNKLTL	97 - 116	20
HFR4	Chothia	-WGRGTQVTVSS	117 - 127	11
	AbM	-WGRGTQVTVSS	117 - 127	11
	Kabat	-WGRGTQVTVSS	117 - 127	11
	Contact	LWGRGTQVTVSS	116 - 127	12
	IMGT	-WGRGTQVTVSS	117 - 127	11

Accession & Annotations

Accession	4i1n_B
Source	PDB 4i1n Submitted 21-NOV-2012 Updated 27-NOV-2013
Name	R104A-CA1697 NANOBODY BINDING TO THE BINARY DHFR.FOLATE COMPLEX
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	OYEN D., STEYAERT J., BARLOW N. 'EXPLORING AN ALTERNATIVE ANTIBODY INTERACTION MECHANISM' TO BE PUBLISHED

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQAGASLRLSCAASERLTVDYAIGWFRQAPGKEREFVAAISWGGGLTVY
GESVEGRFTISRDIAKNTMNLQMNVLRPEDTANYYCAASRISYAVWNTIPYNKLTLWGRG
TQVTVSSHHHHHH