abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	AVQLQESGGGLVQPGGSLRLSCAASGRTFS	1 - 30	30
CDR-H1	SYNMG	31 - 35	5
HFR2	WFRQAPGKGREFVA	36 - 49	14
CDR-H2	SITSSGDKSDYTDSVKG	50 - 66	17
HFR3	RFTISRDNAKNTMYLQMNNLKPEDTATYYCAR	67 - 98	32
CDR-H3	GLGIYIIRARGGYDH	99 - 113	15
HFR4	WGQGTQVTVSS	114 - 124	11
Tail	HHHHHH	124 - 130	6
			130

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	AVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	AbM	AVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	Kabat	AVQLQESGGGLVQPGGSLRLSCAASGRTFS	1 - 30	30
	Contact	AVQLQESGGGLVQPGGSLRLSCAASGRTF-	1 - 29	29
	IMGT	AVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GRTFSSY---	26 - 32	7
	AbM	GRTFSSYNMG	26 - 35	10
	Kabat	-----SYNMG	31 - 35	5
	Contact	----SSYNMG	30 - 35	6
	IMGT	GRTFSSYN--	26 - 33	8
HFR2	Chothia	NMGWFRQAPGKGREFVASI	33 - 51	19
	AbM	---WFRQAPGKGREFVA--	36 - 49	14
	Kabat	---WFRQAPGKGREFVA--	36 - 49	14
	Contact	---WFRQAPGKGRE-----	36 - 46	11
	IMGT	-MGWFRQAPGKGREFVAS-	34 - 50	17
CDR-H2	Chothia	-----TSSGDK---------	52 - 57	6
	AbM	---SITSSGDKSD-------	50 - 59	10
	Kabat	---SITSSGDKSDYTDSVKG	50 - 66	17
	Contact	FVASITSSGDKSD-------	47 - 59	13
	IMGT	----ITSSGDKS--------	51 - 58	8
HFR3	Chothia	SDYTDSVKGRFTISRDNAKNTMYLQMNNLKPEDTATYYCAR	58 - 98	41
	AbM	--YTDSVKGRFTISRDNAKNTMYLQMNNLKPEDTATYYCAR	60 - 98	39
	Kabat	---------RFTISRDNAKNTMYLQMNNLKPEDTATYYCAR	67 - 98	32
	Contact	--YTDSVKGRFTISRDNAKNTMYLQMNNLKPEDTATYYC--	60 - 96	37
	IMGT	-DYTDSVKGRFTISRDNAKNTMYLQMNNLKPEDTATYYC--	59 - 96	38
CDR-H3	Chothia	--GLGIYIIRARGGYDH	99 - 113	15
	AbM	--GLGIYIIRARGGYDH	99 - 113	15
	Kabat	--GLGIYIIRARGGYDH	99 - 113	15
	Contact	ARGLGIYIIRARGGYD-	97 - 112	16
	IMGT	ARGLGIYIIRARGGYDH	97 - 113	17
HFR4	Chothia	-WGQGTQVTVSS	114 - 124	11
	AbM	-WGQGTQVTVSS	114 - 124	11
	Kabat	-WGQGTQVTVSS	114 - 124	11
	Contact	HWGQGTQVTVSS	113 - 124	12
	IMGT	-WGQGTQVTVSS	114 - 124	11

Accession & Annotations

Accession	4kml_B
Source	PDB 4kml Submitted 08-MAY-2013 Updated 24-JAN-2018
Name	PROBING THE N-TERMINAL BETA-SHEET CONVERSION IN THE CRYSTAL STRUCTURE OF THE FULL-LENGTH HUMAN PRION PROTEIN BOUND TO A NANOBODY
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	ABSKHARON N., GIACHIN G., WOHLKONIG A., SOROR H., PARDON E., LEGNAME G., STEYAERT J. 'PROBING THE N-TERMINAL BETA-SHEET CONVERSION IN THE CRYSTAL STRUCTURE OF THE HUMAN PRION PROTEIN BOUND TO A NANOBODY.' J.AM.CHEM.SOC. V. 136 937 2014 ISSN 0002-7863

Tools

Sequences

Amino Acid Sequence:

AVQLQESGGGLVQPGGSLRLSCAASGRTFSSYNMGWFRQAPGKGREFVASITSSGDKSDY
TDSVKGRFTISRDNAKNTMYLQMNNLKPEDTATYYCARGLGIYIIRARGGYDHWGQGTQV
TVSSHHHHHH