abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVKLEESGGGSVQTGGSLRLTCAASGRTSR	1 - 30	30
CDR-H1	SYGMG	31 - 35	5
HFR2	WFRQAPGKEREFVS	36 - 49	14
CDR-H2	GISWRGDSTGYADSVKG	50 - 66	17
HFR3	RFTISRDNAKNTVDLQMNSLKPEDTAIYYCAA	67 - 98	32
CDR-H3	AAGSAWYGTLYEYDY	99 - 113	15
HFR4	WGQGTQVTVSS	114 - 124	11
Tail	ALEHHHHHH	124 - 133	9
			133

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVKLEESGGGSVQTGGSLRLTCAAS-----	1 - 25	25
	AbM	QVKLEESGGGSVQTGGSLRLTCAAS-----	1 - 25	25
	Kabat	QVKLEESGGGSVQTGGSLRLTCAASGRTSR	1 - 30	30
	Contact	QVKLEESGGGSVQTGGSLRLTCAASGRTS-	1 - 29	29
	IMGT	QVKLEESGGGSVQTGGSLRLTCAAS-----	1 - 25	25
CDR-H1	Chothia	GRTSRSY---	26 - 32	7
	AbM	GRTSRSYGMG	26 - 35	10
	Kabat	-----SYGMG	31 - 35	5
	Contact	----RSYGMG	30 - 35	6
	IMGT	GRTSRSYG--	26 - 33	8
HFR2	Chothia	GMGWFRQAPGKEREFVSGI	33 - 51	19
	AbM	---WFRQAPGKEREFVS--	36 - 49	14
	Kabat	---WFRQAPGKEREFVS--	36 - 49	14
	Contact	---WFRQAPGKERE-----	36 - 46	11
	IMGT	-MGWFRQAPGKEREFVSG-	34 - 50	17
CDR-H2	Chothia	-----SWRGDS---------	52 - 57	6
	AbM	---GISWRGDSTG-------	50 - 59	10
	Kabat	---GISWRGDSTGYADSVKG	50 - 66	17
	Contact	FVSGISWRGDSTG-------	47 - 59	13
	IMGT	----ISWRGDST--------	51 - 58	8
HFR3	Chothia	TGYADSVKGRFTISRDNAKNTVDLQMNSLKPEDTAIYYCAA	58 - 98	41
	AbM	--YADSVKGRFTISRDNAKNTVDLQMNSLKPEDTAIYYCAA	60 - 98	39
	Kabat	---------RFTISRDNAKNTVDLQMNSLKPEDTAIYYCAA	67 - 98	32
	Contact	--YADSVKGRFTISRDNAKNTVDLQMNSLKPEDTAIYYC--	60 - 96	37
	IMGT	-GYADSVKGRFTISRDNAKNTVDLQMNSLKPEDTAIYYC--	59 - 96	38
CDR-H3	Chothia	--AAGSAWYGTLYEYDY	99 - 113	15
	AbM	--AAGSAWYGTLYEYDY	99 - 113	15
	Kabat	--AAGSAWYGTLYEYDY	99 - 113	15
	Contact	AAAAGSAWYGTLYEYD-	97 - 112	16
	IMGT	AAAAGSAWYGTLYEYDY	97 - 113	17
HFR4	Chothia	-WGQGTQVTVSS	114 - 124	11
	AbM	-WGQGTQVTVSS	114 - 124	11
	Kabat	-WGQGTQVTVSS	114 - 124	11
	Contact	YWGQGTQVTVSS	113 - 124	12
	IMGT	-WGQGTQVTVSS	114 - 124	11

Accession & Annotations

Accession	4krm_H
Source	PDB 4krm Submitted 16-MAY-2013 Updated 28-AUG-2013
Name	NANOBODY/VHH DOMAIN 7D12 IN COMPLEX WITH DOMAIN III OF THE EXTRACELLULAR REGION OF EGFR, PH 3.5
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 4krl_B 4krm_B 4krm_D 4krm_F 4krm_J 4krm_L
References	SCHMITZ R., BAGCHI A., ROOVERS C., VAN BERGEN EN HENEGOUWEN P., FERGUSON M. 'STRUCTURAL EVALUATION OF EGFR INHIBITION MECHANISMS FOR NANOBODIES/VHH DOMAINS.' STRUCTURE V. 21 1214 2013 ISSN 0969-2126

Tools

Sequences

Amino Acid Sequence:

QVKLEESGGGSVQTGGSLRLTCAASGRTSRSYGMGWFRQAPGKEREFVSGISWRGDSTGY
ADSVKGRFTISRDNAKNTVDLQMNSLKPEDTAIYYCAAAAGSAWYGTLYEYDYWGQGTQV
TVSSALEHHHHHH