abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQPGGSLRLSCAASGRTFS	1 - 30	30
CDR-H1	SYAMG	31 - 35	5
HFR2	WFRQAPGKQREFVA	36 - 49	14
CDR-H2	AIRWSGGYTYYTDSVKG	50 - 66	17
HFR3	RFTISRDNAKTTVYLQMNSLKPEDTAVYYCAA	67 - 98	32
CDR-H3	TYLSSDYSRYALPQRPLDYDY	99 - 119	21
HFR4	WGQGTQVTVSS	120 - 130	11
Tail	LEHHHHHH	130 - 138	8
			138

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGLVQPGGSLRLSCAASGRTFS	1 - 30	30
	Contact	QVQLQESGGGLVQPGGSLRLSCAASGRTF-	1 - 29	29
	IMGT	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GRTFSSY---	26 - 32	7
	AbM	GRTFSSYAMG	26 - 35	10
	Kabat	-----SYAMG	31 - 35	5
	Contact	----SSYAMG	30 - 35	6
	IMGT	GRTFSSYA--	26 - 33	8
HFR2	Chothia	AMGWFRQAPGKQREFVAAI	33 - 51	19
	AbM	---WFRQAPGKQREFVA--	36 - 49	14
	Kabat	---WFRQAPGKQREFVA--	36 - 49	14
	Contact	---WFRQAPGKQRE-----	36 - 46	11
	IMGT	-MGWFRQAPGKQREFVAA-	34 - 50	17
CDR-H2	Chothia	-----RWSGGY---------	52 - 57	6
	AbM	---AIRWSGGYTY-------	50 - 59	10
	Kabat	---AIRWSGGYTYYTDSVKG	50 - 66	17
	Contact	FVAAIRWSGGYTY-------	47 - 59	13
	IMGT	----IRWSGGYT--------	51 - 58	8
HFR3	Chothia	TYYTDSVKGRFTISRDNAKTTVYLQMNSLKPEDTAVYYCAA	58 - 98	41
	AbM	--YTDSVKGRFTISRDNAKTTVYLQMNSLKPEDTAVYYCAA	60 - 98	39
	Kabat	---------RFTISRDNAKTTVYLQMNSLKPEDTAVYYCAA	67 - 98	32
	Contact	--YTDSVKGRFTISRDNAKTTVYLQMNSLKPEDTAVYYC--	60 - 96	37
	IMGT	-YYTDSVKGRFTISRDNAKTTVYLQMNSLKPEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--TYLSSDYSRYALPQRPLDYDY	99 - 119	21
	AbM	--TYLSSDYSRYALPQRPLDYDY	99 - 119	21
	Kabat	--TYLSSDYSRYALPQRPLDYDY	99 - 119	21
	Contact	AATYLSSDYSRYALPQRPLDYD-	97 - 118	22
	IMGT	AATYLSSDYSRYALPQRPLDYDY	97 - 119	23
HFR4	Chothia	-WGQGTQVTVSS	120 - 130	11
	AbM	-WGQGTQVTVSS	120 - 130	11
	Kabat	-WGQGTQVTVSS	120 - 130	11
	Contact	YWGQGTQVTVSS	119 - 130	12
	IMGT	-WGQGTQVTVSS	120 - 130	11

Accession & Annotations

Accession	4kro_B
Source	PDB 4kro Submitted 16-MAY-2013 Updated 28-AUG-2013
Name	NANOBODY/VHH DOMAIN EGA1 IN COMPLEX WITH THE EXTRACELLULAR REGION OF EGFR
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 4krn_A
References	SCHMITZ R., BAGCHI A., ROOVERS C., VAN BERGEN EN HENEGOUWEN M., FERGUSON M. 'STRUCTURAL EVALUATION OF EGFR INHIBITION MECHANISMS FOR NANOBODIES/VHH DOMAINS.' STRUCTURE V. 21 1214 2013 ISSN 0969-2126

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQPGGSLRLSCAASGRTFSSYAMGWFRQAPGKQREFVAAIRWSGGYTYY
TDSVKGRFTISRDNAKTTVYLQMNSLKPEDTAVYYCAATYLSSDYSRYALPQRPLDYDYW
GQGTQVTVSSLEHHHHHH