abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLVESGGGLVQAGGSLRLSCAASGRTFS	1 - 30	30
CDR-H1	SYAMG	31 - 35	5
HFR2	WFRQAPGKEREFVV	36 - 49	14
CDR-H2	AINWSSGSTYYADSVKG	50 - 66	17
HFR3	RFTISRDNAKNTMYLQMNSLKPEDTAVYYCAA	67 - 98	32
CDR-H3	GYQINSGNYNFKDYEYDY	99 - 116	18
HFR4	WGQGTQVTVSS	117 - 127	11
Tail	ALEHHHHHH	127 - 136	9
			136

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	AbM	EVQLVESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	Kabat	EVQLVESGGGLVQAGGSLRLSCAASGRTFS	1 - 30	30
	Contact	EVQLVESGGGLVQAGGSLRLSCAASGRTF-	1 - 29	29
	IMGT	EVQLVESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GRTFSSY---	26 - 32	7
	AbM	GRTFSSYAMG	26 - 35	10
	Kabat	-----SYAMG	31 - 35	5
	Contact	----SSYAMG	30 - 35	6
	IMGT	GRTFSSYA--	26 - 33	8
HFR2	Chothia	AMGWFRQAPGKEREFVVAI	33 - 51	19
	AbM	---WFRQAPGKEREFVV--	36 - 49	14
	Kabat	---WFRQAPGKEREFVV--	36 - 49	14
	Contact	---WFRQAPGKERE-----	36 - 46	11
	IMGT	-MGWFRQAPGKEREFVVA-	34 - 50	17
CDR-H2	Chothia	-----NWSSGS---------	52 - 57	6
	AbM	---AINWSSGSTY-------	50 - 59	10
	Kabat	---AINWSSGSTYYADSVKG	50 - 66	17
	Contact	FVVAINWSSGSTY-------	47 - 59	13
	IMGT	----INWSSGST--------	51 - 58	8
HFR3	Chothia	TYYADSVKGRFTISRDNAKNTMYLQMNSLKPEDTAVYYCAA	58 - 98	41
	AbM	--YADSVKGRFTISRDNAKNTMYLQMNSLKPEDTAVYYCAA	60 - 98	39
	Kabat	---------RFTISRDNAKNTMYLQMNSLKPEDTAVYYCAA	67 - 98	32
	Contact	--YADSVKGRFTISRDNAKNTMYLQMNSLKPEDTAVYYC--	60 - 96	37
	IMGT	-YYADSVKGRFTISRDNAKNTMYLQMNSLKPEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--GYQINSGNYNFKDYEYDY	99 - 116	18
	AbM	--GYQINSGNYNFKDYEYDY	99 - 116	18
	Kabat	--GYQINSGNYNFKDYEYDY	99 - 116	18
	Contact	AAGYQINSGNYNFKDYEYD-	97 - 115	19
	IMGT	AAGYQINSGNYNFKDYEYDY	97 - 116	20
HFR4	Chothia	-WGQGTQVTVSS	117 - 127	11
	AbM	-WGQGTQVTVSS	117 - 127	11
	Kabat	-WGQGTQVTVSS	117 - 127	11
	Contact	YWGQGTQVTVSS	116 - 127	12
	IMGT	-WGQGTQVTVSS	117 - 127	11

Accession & Annotations

Accession	4krp_B
Source	PDB 4krp Submitted 16-MAY-2013 Updated 28-AUG-2013
Name	NANOBODY/VHH DOMAIN 9G8 IN COMPLEX WITH THE EXTRACELLULAR REGION OF EGFR
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	SCHMITZ R., BAGCHI A., ROOVERS C., VAN BERGEN EN HENEGOUWEN P., FERGUSON M. 'STRUCTURAL EVALUATION OF EGFR INHIBITION MECHANISMS FOR NANOBODIES/VHH DOMAINS.' STRUCTURE V. 21 1214 2013 ISSN 0969-2126

Tools

Sequences

Amino Acid Sequence:

EVQLVESGGGLVQAGGSLRLSCAASGRTFSSYAMGWFRQAPGKEREFVVAINWSSGSTYY
ADSVKGRFTISRDNAKNTMYLQMNSLKPEDTAVYYCAAGYQINSGNYNFKDYEYDYWGQG
TQVTVSSALEHHHHHH