abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLVETGGGLVQPGGSLTLSCAGSGGTLE	1 - 30	30
CDR-H1	HYAIG	31 - 35	5
HFR2	WFRQAPGKEHEWLV	36 - 49	14
CDR-H2	CNRGEYGSTVYVDSVKG	50 - 66	17
HFR3	RFTASRDNAKNTVYLQLNSLKPDDTGIYYCVS	67 - 98	32
CDR-H3	GCYSWRGP	99 - 106	8
HFR4	WGQGTQVTVS	107 - 116	10
			116

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLVETGGGLVQPGGSLTLSCAGS-----	1 - 25	25
	AbM	QVQLVETGGGLVQPGGSLTLSCAGS-----	1 - 25	25
	Kabat	QVQLVETGGGLVQPGGSLTLSCAGSGGTLE	1 - 30	30
	Contact	QVQLVETGGGLVQPGGSLTLSCAGSGGTL-	1 - 29	29
	IMGT	QVQLVETGGGLVQPGGSLTLSCAGS-----	1 - 25	25
CDR-H1	Chothia	GGTLEHY---	26 - 32	7
	AbM	GGTLEHYAIG	26 - 35	10
	Kabat	-----HYAIG	31 - 35	5
	Contact	----EHYAIG	30 - 35	6
	IMGT	GGTLEHYA--	26 - 33	8
HFR2	Chothia	AIGWFRQAPGKEHEWLVCN	33 - 51	19
	AbM	---WFRQAPGKEHEWLV--	36 - 49	14
	Kabat	---WFRQAPGKEHEWLV--	36 - 49	14
	Contact	---WFRQAPGKEHE-----	36 - 46	11
	IMGT	-IGWFRQAPGKEHEWLVC-	34 - 50	17
CDR-H2	Chothia	-----RGEYGS---------	52 - 57	6
	AbM	---CNRGEYGSTV-------	50 - 59	10
	Kabat	---CNRGEYGSTVYVDSVKG	50 - 66	17
	Contact	WLVCNRGEYGSTV-------	47 - 59	13
	IMGT	----NRGEYGST--------	51 - 58	8
HFR3	Chothia	TVYVDSVKGRFTASRDNAKNTVYLQLNSLKPDDTGIYYCVS	58 - 98	41
	AbM	--YVDSVKGRFTASRDNAKNTVYLQLNSLKPDDTGIYYCVS	60 - 98	39
	Kabat	---------RFTASRDNAKNTVYLQLNSLKPDDTGIYYCVS	67 - 98	32
	Contact	--YVDSVKGRFTASRDNAKNTVYLQLNSLKPDDTGIYYC--	60 - 96	37
	IMGT	-VYVDSVKGRFTASRDNAKNTVYLQLNSLKPDDTGIYYC--	59 - 96	38
CDR-H3	Chothia	--GCYSWRGP	99 - 106	8
	AbM	--GCYSWRGP	99 - 106	8
	Kabat	--GCYSWRGP	99 - 106	8
	Contact	VSGCYSWRG-	97 - 105	9
	IMGT	VSGCYSWRGP	97 - 106	10
HFR4	Chothia	-WGQGTQVTVS	107 - 116	10
	AbM	-WGQGTQVTVS	107 - 116	10
	Kabat	-WGQGTQVTVS	107 - 116	10
	Contact	PWGQGTQVTVS	106 - 116	11
	IMGT	-WGQGTQVTVS	107 - 116	10

Accession & Annotations

Accession	4lgp_D
Source	PDB 4lgp Submitted 28-JUN-2013 Updated 15-NOV-2017
Name	RICIN A CHAIN BOUND TO CAMELID NANOBODY (VHH1)
Organism	Vicugna pacos
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 4lgp_B
References	RUDOLPH J., VANCE J., CHEUNG J., FRANKLIN C., BURSHTEYN F., CASSIDY S., GARY N., HERRERA C., SHOEMAKER B., MANTIS J. 'CRYSTAL STRUCTURES OF RICIN TOXIN'S ENZYMATIC SUBUNIT (RTA) IN COMPLEX WITH NEUTRALIZING AND NON-NEUTRALIZING SINGLE-CHAIN ANTIBODIES.' J.MOL.BIOL. V. 426 3057 2014 ISSN 0022-2836

Tools

Sequences

Amino Acid Sequence:

QVQLVETGGGLVQPGGSLTLSCAGSGGTLEHYAIGWFRQAPGKEHEWLVCNRGEYGSTVY
VDSVKGRFTASRDNAKNTVYLQLNSLKPDDTGIYYCVSGCYSWRGPWGQGTQVTVS