abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	VQLVESGGGLVQPGGSLRLHCAASGSIAS	1 - 29	29
CDR-H1	IYRTC	30 - 34	5
HFR2	WYRQGTGKQRELVA	35 - 48	14
CDR-H2	AITSGGNTYYADSVKG	49 - 64	16
HFR3	RFTISRDNAKNTIDLQMNSLKPEDTAVYYCNA	65 - 96	32
CDR-H3	DEAGIGGFNDY	97 - 107	11
HFR4	WGQGTQVTVSS	108 - 118	11
Tail	AHHS	118 - 122	4
			122

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	VQLVESGGGLVQPGGSLRLHCAAS-----	1 - 24	24
	AbM	VQLVESGGGLVQPGGSLRLHCAAS-----	1 - 24	24
	Kabat	VQLVESGGGLVQPGGSLRLHCAASGSIAS	1 - 29	29
	Contact	VQLVESGGGLVQPGGSLRLHCAASGSIA-	1 - 28	28
	IMGT	VQLVESGGGLVQPGGSLRLHCAAS-----	1 - 24	24
CDR-H1	Chothia	GSIASIY---	25 - 31	7
	AbM	GSIASIYRTC	25 - 34	10
	Kabat	-----IYRTC	30 - 34	5
	Contact	----SIYRTC	29 - 34	6
	IMGT	GSIASIYR--	25 - 32	8
HFR2	Chothia	RTCWYRQGTGKQRELVAAI	32 - 50	19
	AbM	---WYRQGTGKQRELVA--	35 - 48	14
	Kabat	---WYRQGTGKQRELVA--	35 - 48	14
	Contact	---WYRQGTGKQRE-----	35 - 45	11
	IMGT	-TCWYRQGTGKQRELVAA-	33 - 49	17
CDR-H2	Chothia	-----TSGGN---------	51 - 55	5
	AbM	---AITSGGNTY-------	49 - 57	9
	Kabat	---AITSGGNTYYADSVKG	49 - 64	16
	Contact	LVAAITSGGNTY-------	46 - 57	12
	IMGT	----ITSGGNT--------	50 - 56	7
HFR3	Chothia	TYYADSVKGRFTISRDNAKNTIDLQMNSLKPEDTAVYYCNA	56 - 96	41
	AbM	--YADSVKGRFTISRDNAKNTIDLQMNSLKPEDTAVYYCNA	58 - 96	39
	Kabat	---------RFTISRDNAKNTIDLQMNSLKPEDTAVYYCNA	65 - 96	32
	Contact	--YADSVKGRFTISRDNAKNTIDLQMNSLKPEDTAVYYC--	58 - 94	37
	IMGT	-YYADSVKGRFTISRDNAKNTIDLQMNSLKPEDTAVYYC--	57 - 94	38
CDR-H3	Chothia	--DEAGIGGFNDY	97 - 107	11
	AbM	--DEAGIGGFNDY	97 - 107	11
	Kabat	--DEAGIGGFNDY	97 - 107	11
	Contact	NADEAGIGGFND-	95 - 106	12
	IMGT	NADEAGIGGFNDY	95 - 107	13
HFR4	Chothia	-WGQGTQVTVSS	108 - 118	11
	AbM	-WGQGTQVTVSS	108 - 118	11
	Kabat	-WGQGTQVTVSS	108 - 118	11
	Contact	YWGQGTQVTVSS	107 - 118	12
	IMGT	-WGQGTQVTVSS	108 - 118	11

Accession & Annotations

Accession	4lgr_B
Source	PDB 4lgr Submitted 28-JUN-2013 Updated 15-NOV-2017
Name	RICIN A CHAIN BOUND TO CAMELID NANOBODY (VHH3)
Organism	Vicugna pacos
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	RUDOLPH J., VANCE J., CHEUNG J., FRANKLIN C., BURSHTEYN F., CASSIDY S., GARY N., HERRERA C., SHOEMAKER B., MANTIS J. 'CRYSTAL STRUCTURES OF RICIN TOXIN'S ENZYMATIC SUBUNIT (RTA) IN COMPLEX WITH NEUTRALIZING AND NON-NEUTRALIZING SINGLE-CHAIN ANTIBODIES.' J.MOL.BIOL. V. 426 3057 2014 ISSN 0022-2836

Tools

Sequences

Amino Acid Sequence:

VQLVESGGGLVQPGGSLRLHCAASGSIASIYRTCWYRQGTGKQRELVAAITSGGNTYYAD
SVKGRFTISRDNAKNTIDLQMNSLKPEDTAVYYCNADEAGIGGFNDYWGQGTQVTVSSAH
HS