abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLVESGGGLVQAGGSLSLSCAASGGDFS	1 - 30	30
CDR-H1	RNAMA	31 - 35	5
HFR2	WFRQAPGKEREFVA	36 - 49	14
CDR-H2	SINWTGSGTYYLDSVKG	50 - 66	17
HFR3	RFTISRDNAKNALYLQMNNLKPEDTAVYYCAR	67 - 98	32
CDR-H3	STVFAEITGLAGYQSGSYDY	99 - 118	20
HFR4	WGQGTQVTVSS	119 - 129	11
			129

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLVESGGGLVQAGGSLSLSCAAS-----	1 - 25	25
	AbM	QVQLVESGGGLVQAGGSLSLSCAAS-----	1 - 25	25
	Kabat	QVQLVESGGGLVQAGGSLSLSCAASGGDFS	1 - 30	30
	Contact	QVQLVESGGGLVQAGGSLSLSCAASGGDF-	1 - 29	29
	IMGT	QVQLVESGGGLVQAGGSLSLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GGDFSRN---	26 - 32	7
	AbM	GGDFSRNAMA	26 - 35	10
	Kabat	-----RNAMA	31 - 35	5
	Contact	----SRNAMA	30 - 35	6
	IMGT	GGDFSRNA--	26 - 33	8
HFR2	Chothia	AMAWFRQAPGKEREFVASI	33 - 51	19
	AbM	---WFRQAPGKEREFVA--	36 - 49	14
	Kabat	---WFRQAPGKEREFVA--	36 - 49	14
	Contact	---WFRQAPGKERE-----	36 - 46	11
	IMGT	-MAWFRQAPGKEREFVAS-	34 - 50	17
CDR-H2	Chothia	-----NWTGSG---------	52 - 57	6
	AbM	---SINWTGSGTY-------	50 - 59	10
	Kabat	---SINWTGSGTYYLDSVKG	50 - 66	17
	Contact	FVASINWTGSGTY-------	47 - 59	13
	IMGT	----INWTGSGT--------	51 - 58	8
HFR3	Chothia	TYYLDSVKGRFTISRDNAKNALYLQMNNLKPEDTAVYYCAR	58 - 98	41
	AbM	--YLDSVKGRFTISRDNAKNALYLQMNNLKPEDTAVYYCAR	60 - 98	39
	Kabat	---------RFTISRDNAKNALYLQMNNLKPEDTAVYYCAR	67 - 98	32
	Contact	--YLDSVKGRFTISRDNAKNALYLQMNNLKPEDTAVYYC--	60 - 96	37
	IMGT	-YYLDSVKGRFTISRDNAKNALYLQMNNLKPEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--STVFAEITGLAGYQSGSYDY	99 - 118	20
	AbM	--STVFAEITGLAGYQSGSYDY	99 - 118	20
	Kabat	--STVFAEITGLAGYQSGSYDY	99 - 118	20
	Contact	ARSTVFAEITGLAGYQSGSYD-	97 - 117	21
	IMGT	ARSTVFAEITGLAGYQSGSYDY	97 - 118	22
HFR4	Chothia	-WGQGTQVTVSS	119 - 129	11
	AbM	-WGQGTQVTVSS	119 - 129	11
	Kabat	-WGQGTQVTVSS	119 - 129	11
	Contact	YWGQGTQVTVSS	118 - 129	12
	IMGT	-WGQGTQVTVSS	119 - 129	11

Accession & Annotations

Accession	4lgs_B
Source	PDB 4lgs Submitted 28-JUN-2013 Updated 15-NOV-2017
Name	RICIN A CHAIN BOUND TO CAMELID NANOBODY (VHH4)
Organism	Vicugna pacos
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	RUDOLPH J., VANCE J., CHEUNG J., FRANKLIN C., BURSHTEYN F., CASSIDY S., GARY N., HERRERA C., SHOEMAKER B., MANTIS J. 'CRYSTAL STRUCTURES OF RICIN TOXIN'S ENZYMATIC SUBUNIT (RTA) IN COMPLEX WITH NEUTRALIZING AND NON-NEUTRALIZING SINGLE-CHAIN ANTIBODIES.' J.MOL.BIOL. V. 426 3057 2014 ISSN 0022-2836

Tools

Sequences

Amino Acid Sequence:

QVQLVESGGGLVQAGGSLSLSCAASGGDFSRNAMAWFRQAPGKEREFVASINWTGSGTYY
LDSVKGRFTISRDNAKNALYLQMNNLKPEDTAVYYCARSTVFAEITGLAGYQSGSYDYWG
QGTQVTVSS