abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLVESGGGLVQAGGSLRLSCAASGSIVN	1 - 30	30
CDR-H1	FETMG	31 - 35	5
HFR2	WYRQAPGKERELVA	36 - 49	14
CDR-H2	TITNEGSSNYADSVKG	50 - 65	16
HFR3	RFTISGDNAKNTVSLQMNSLKPEDTAVYYCSA	66 - 97	32
CDR-H3	TFGSRWPYAHSDH	98 - 110	13
HFR4	WGQGTQVTVS	111 - 120	10
			120

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLVESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLVESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLVESGGGLVQAGGSLRLSCAASGSIVN	1 - 30	30
	Contact	QVQLVESGGGLVQAGGSLRLSCAASGSIV-	1 - 29	29
	IMGT	QVQLVESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GSIVNFE---	26 - 32	7
	AbM	GSIVNFETMG	26 - 35	10
	Kabat	-----FETMG	31 - 35	5
	Contact	----NFETMG	30 - 35	6
	IMGT	GSIVNFET--	26 - 33	8
HFR2	Chothia	TMGWYRQAPGKERELVATI	33 - 51	19
	AbM	---WYRQAPGKERELVA--	36 - 49	14
	Kabat	---WYRQAPGKERELVA--	36 - 49	14
	Contact	---WYRQAPGKERE-----	36 - 46	11
	IMGT	-MGWYRQAPGKERELVAT-	34 - 50	17
CDR-H2	Chothia	-----TNEGS---------	52 - 56	5
	AbM	---TITNEGSSN-------	50 - 58	9
	Kabat	---TITNEGSSNYADSVKG	50 - 65	16
	Contact	LVATITNEGSSN-------	47 - 58	12
	IMGT	----ITNEGSS--------	51 - 57	7
HFR3	Chothia	SNYADSVKGRFTISGDNAKNTVSLQMNSLKPEDTAVYYCSA	57 - 97	41
	AbM	--YADSVKGRFTISGDNAKNTVSLQMNSLKPEDTAVYYCSA	59 - 97	39
	Kabat	---------RFTISGDNAKNTVSLQMNSLKPEDTAVYYCSA	66 - 97	32
	Contact	--YADSVKGRFTISGDNAKNTVSLQMNSLKPEDTAVYYC--	59 - 95	37
	IMGT	-NYADSVKGRFTISGDNAKNTVSLQMNSLKPEDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--TFGSRWPYAHSDH	98 - 110	13
	AbM	--TFGSRWPYAHSDH	98 - 110	13
	Kabat	--TFGSRWPYAHSDH	98 - 110	13
	Contact	SATFGSRWPYAHSD-	96 - 109	14
	IMGT	SATFGSRWPYAHSDH	96 - 110	15
HFR4	Chothia	-WGQGTQVTVS	111 - 120	10
	AbM	-WGQGTQVTVS	111 - 120	10
	Kabat	-WGQGTQVTVS	111 - 120	10
	Contact	HWGQGTQVTVS	110 - 120	11
	IMGT	-WGQGTQVTVS	111 - 120	10

Accession & Annotations

Accession	4lhj_B
Source	PDB 4lhj Submitted 01-JUL-2013 Updated 15-NOV-2017
Name	RICIN A CHAIN BOUND TO CAMELID NANOBODY (VHH5)
Organism	Vicugna pacos
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	RUDOLPH J., VANCE J., CHEUNG J., FRANKLIN C., BURSHTEYN F., CASSIDY S., GARY N., HERRERA C., SHOEMAKER B., MANTIS J. 'CRYSTAL STRUCTURES OF RICIN TOXIN'S ENZYMATIC SUBUNIT (RTA) IN COMPLEX WITH NEUTRALIZING AND NON-NEUTRALIZING SINGLE-CHAIN ANTIBODIES.' J.MOL.BIOL. V. 426 3057 2014 ISSN 0022-2836

Tools

Sequences

Amino Acid Sequence:

QVQLVESGGGLVQAGGSLRLSCAASGSIVNFETMGWYRQAPGKERELVATITNEGSSNYA
DSVKGRFTISGDNAKNTVSLQMNSLKPEDTAVYYCSATFGSRWPYAHSDHWGQGTQVTVS