abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQAGGSLRLSCAVSGSIFR	1 - 30	30
CDR-H1	LSTMG	31 - 35	5
HFR2	WYRQAPGKQREFVA	36 - 49	14
CDR-H2	SITSYGDTNYRDSVKG	50 - 65	16
HFR3	RFTISRDNAKNTVYLQMNSLKPEDTAVYYCNA	66 - 97	32
CDR-H3	NIEAGTYYGPGRDY	98 - 111	14
HFR4	WGQGTQVTVSS	112 - 122	11
Tail	HHHHHH	122 - 128	6
			128

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQAGGSLRLSCAVS-----	1 - 25	25
	AbM	QVQLQESGGGLVQAGGSLRLSCAVS-----	1 - 25	25
	Kabat	QVQLQESGGGLVQAGGSLRLSCAVSGSIFR	1 - 30	30
	Contact	QVQLQESGGGLVQAGGSLRLSCAVSGSIF-	1 - 29	29
	IMGT	QVQLQESGGGLVQAGGSLRLSCAVS-----	1 - 25	25
CDR-H1	Chothia	GSIFRLS---	26 - 32	7
	AbM	GSIFRLSTMG	26 - 35	10
	Kabat	-----LSTMG	31 - 35	5
	Contact	----RLSTMG	30 - 35	6
	IMGT	GSIFRLST--	26 - 33	8
HFR2	Chothia	TMGWYRQAPGKQREFVASI	33 - 51	19
	AbM	---WYRQAPGKQREFVA--	36 - 49	14
	Kabat	---WYRQAPGKQREFVA--	36 - 49	14
	Contact	---WYRQAPGKQRE-----	36 - 46	11
	IMGT	-MGWYRQAPGKQREFVAS-	34 - 50	17
CDR-H2	Chothia	-----TSYGD---------	52 - 56	5
	AbM	---SITSYGDTN-------	50 - 58	9
	Kabat	---SITSYGDTNYRDSVKG	50 - 65	16
	Contact	FVASITSYGDTN-------	47 - 58	12
	IMGT	----ITSYGDT--------	51 - 57	7
HFR3	Chothia	TNYRDSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCNA	57 - 97	41
	AbM	--YRDSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCNA	59 - 97	39
	Kabat	---------RFTISRDNAKNTVYLQMNSLKPEDTAVYYCNA	66 - 97	32
	Contact	--YRDSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYC--	59 - 95	37
	IMGT	-NYRDSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--NIEAGTYYGPGRDY	98 - 111	14
	AbM	--NIEAGTYYGPGRDY	98 - 111	14
	Kabat	--NIEAGTYYGPGRDY	98 - 111	14
	Contact	NANIEAGTYYGPGRD-	96 - 110	15
	IMGT	NANIEAGTYYGPGRDY	96 - 111	16
HFR4	Chothia	-WGQGTQVTVSS	112 - 122	11
	AbM	-WGQGTQVTVSS	112 - 122	11
	Kabat	-WGQGTQVTVSS	112 - 122	11
	Contact	YWGQGTQVTVSS	111 - 122	12
	IMGT	-WGQGTQVTVSS	112 - 122	11

Accession & Annotations

Accession	4p2c_J
Source	PDB 4p2c Submitted 18-FEB-2014 Updated 27-SEP-2017
Name	COMPLEX OF SHIGA TOXIN 2E WITH A NEUTRALIZING SINGLE-DOMAIN ANTIBODY
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 4p2c_G 4p2c_H 4p2c_I 4p2c_K
References	LO W., MOONENS K., DE KERPEL M., BRYS L., PARDON E., REMAUT H., DE GREVE H. 'THE MOLECULAR MECHANISM OF SHIGA TOXIN STX2E NEUTRALIZATION BY A SINGLE-DOMAIN ANTIBODY TARGETING THE CELL RECEPTOR-BINDING DOMAIN.' J.BIOL.CHEM. V. 289 25374 2014 ESSN 1083-351X

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQAGGSLRLSCAVSGSIFRLSTMGWYRQAPGKQREFVASITSYGDTNYR
DSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCNANIEAGTYYGPGRDYWGQGTQVTV
SSHHHHHH