abYsis

Numbering & Regions

Comparison Organism:

Calculating, please wait ...

Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQAGGSLRLSCAASGSIFA	1 - 30	30
CDR-H1	LNIMG	31 - 35	5
HFR2	WYRQAPGKQRELVA	36 - 49	14
CDR-H2	AIHSGGTTNYANSVKG	50 - 65	16
HFR3	RFTISRDNAANTVYLQMNSLKPEDTAVYYCNV	66 - 97	32
CDR-H3	KDFGAIIYDYDY	98 - 109	12
HFR4	WGQGTQVTVSS	110 - 120	11
			120

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGLVQAGGSLRLSCAASGSIFA	1 - 30	30
	Contact	QVQLQESGGGLVQAGGSLRLSCAASGSIF-	1 - 29	29
	IMGT	QVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GSIFALN---	26 - 32	7
	AbM	GSIFALNIMG	26 - 35	10
	Kabat	-----LNIMG	31 - 35	5
	Contact	----ALNIMG	30 - 35	6
	IMGT	GSIFALNI--	26 - 33	8
HFR2	Chothia	IMGWYRQAPGKQRELVAAI	33 - 51	19
	AbM	---WYRQAPGKQRELVA--	36 - 49	14
	Kabat	---WYRQAPGKQRELVA--	36 - 49	14
	Contact	---WYRQAPGKQRE-----	36 - 46	11
	IMGT	-MGWYRQAPGKQRELVAA-	34 - 50	17
CDR-H2	Chothia	-----HSGGT---------	52 - 56	5
	AbM	---AIHSGGTTN-------	50 - 58	9
	Kabat	---AIHSGGTTNYANSVKG	50 - 65	16
	Contact	LVAAIHSGGTTN-------	47 - 58	12
	IMGT	----IHSGGTT--------	51 - 57	7
HFR3	Chothia	TNYANSVKGRFTISRDNAANTVYLQMNSLKPEDTAVYYCNV	57 - 97	41
	AbM	--YANSVKGRFTISRDNAANTVYLQMNSLKPEDTAVYYCNV	59 - 97	39
	Kabat	---------RFTISRDNAANTVYLQMNSLKPEDTAVYYCNV	66 - 97	32
	Contact	--YANSVKGRFTISRDNAANTVYLQMNSLKPEDTAVYYC--	59 - 95	37
	IMGT	-NYANSVKGRFTISRDNAANTVYLQMNSLKPEDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--KDFGAIIYDYDY	98 - 109	12
	AbM	--KDFGAIIYDYDY	98 - 109	12
	Kabat	--KDFGAIIYDYDY	98 - 109	12
	Contact	NVKDFGAIIYDYD-	96 - 108	13
	IMGT	NVKDFGAIIYDYDY	96 - 109	14
HFR4	Chothia	-WGQGTQVTVSS	110 - 120	11
	AbM	-WGQGTQVTVSS	110 - 120	11
	Kabat	-WGQGTQVTVSS	110 - 120	11
	Contact	YWGQGTQVTVSS	109 - 120	12
	IMGT	-WGQGTQVTVSS	110 - 120	11

Accession & Annotations

Accession	4qkx_B
Source	PDB 4qkx Submitted 10-JUN-2014 Updated 28-JUN-2017
Name	STRUCTURE OF BETA2 ADRENOCEPTOR BOUND TO A COVALENT AGONIST AND AN ENGINEERED NANOBODY
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 4lde_B 4ldl_B 4ldo_B
References	WEICHERT D., KRUSE C., MANGLIK A., HILLER C., ZHANG C., HUBNER H., KOBILKA K., GMEINER P. 'COVALENT AGONISTS FOR STUDYING G PROTEIN-COUPLED RECEPTOR ACTIVATION.' PROC.NATL.ACAD.SCI.USA V. 111 10744 2014 ISSN 0027-8424

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQAGGSLRLSCAASGSIFALNIMGWYRQAPGKQRELVAAIHSGGTTNYA
NSVKGRFTISRDNAANTVYLQMNSLKPEDTAVYYCNVKDFGAIIYDYDYWGQGTQVTVSS