abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	DVQLVESGGGLVHPGGSLRLSCAASGRTFS	1 - 30	30
CDR-H1	DYALG	31 - 35	5
HFR2	WFRQAPGKDREFVA	36 - 49	14
CDR-H2	AISWSGGSTYYADSVQG	50 - 66	17
HFR3	RFTISRDNDKNSVYLQMNSLKPEDTAVYYCAA	67 - 98	32
CDR-H3	DKYYTGPGGESVYDY	99 - 113	15
HFR4	WGRGTQVTVSS	114 - 124	11
Tail	HHHHHH	124 - 130	6
			130

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	DVQLVESGGGLVHPGGSLRLSCAAS-----	1 - 25	25
	AbM	DVQLVESGGGLVHPGGSLRLSCAAS-----	1 - 25	25
	Kabat	DVQLVESGGGLVHPGGSLRLSCAASGRTFS	1 - 30	30
	Contact	DVQLVESGGGLVHPGGSLRLSCAASGRTF-	1 - 29	29
	IMGT	DVQLVESGGGLVHPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GRTFSDY---	26 - 32	7
	AbM	GRTFSDYALG	26 - 35	10
	Kabat	-----DYALG	31 - 35	5
	Contact	----SDYALG	30 - 35	6
	IMGT	GRTFSDYA--	26 - 33	8
HFR2	Chothia	ALGWFRQAPGKDREFVAAI	33 - 51	19
	AbM	---WFRQAPGKDREFVA--	36 - 49	14
	Kabat	---WFRQAPGKDREFVA--	36 - 49	14
	Contact	---WFRQAPGKDRE-----	36 - 46	11
	IMGT	-LGWFRQAPGKDREFVAA-	34 - 50	17
CDR-H2	Chothia	-----SWSGGS---------	52 - 57	6
	AbM	---AISWSGGSTY-------	50 - 59	10
	Kabat	---AISWSGGSTYYADSVQG	50 - 66	17
	Contact	FVAAISWSGGSTY-------	47 - 59	13
	IMGT	----ISWSGGST--------	51 - 58	8
HFR3	Chothia	TYYADSVQGRFTISRDNDKNSVYLQMNSLKPEDTAVYYCAA	58 - 98	41
	AbM	--YADSVQGRFTISRDNDKNSVYLQMNSLKPEDTAVYYCAA	60 - 98	39
	Kabat	---------RFTISRDNDKNSVYLQMNSLKPEDTAVYYCAA	67 - 98	32
	Contact	--YADSVQGRFTISRDNDKNSVYLQMNSLKPEDTAVYYC--	60 - 96	37
	IMGT	-YYADSVQGRFTISRDNDKNSVYLQMNSLKPEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--DKYYTGPGGESVYDY	99 - 113	15
	AbM	--DKYYTGPGGESVYDY	99 - 113	15
	Kabat	--DKYYTGPGGESVYDY	99 - 113	15
	Contact	AADKYYTGPGGESVYD-	97 - 112	16
	IMGT	AADKYYTGPGGESVYDY	97 - 113	17
HFR4	Chothia	-WGRGTQVTVSS	114 - 124	11
	AbM	-WGRGTQVTVSS	114 - 124	11
	Kabat	-WGRGTQVTVSS	114 - 124	11
	Contact	YWGRGTQVTVSS	113 - 124	12
	IMGT	-WGRGTQVTVSS	114 - 124	11

Accession & Annotations

Accession	4qlr_A
Source	PDB 4qlr Submitted 13-JUN-2014 Updated 22-NOV-2017
Name	LLAMA NANOBODY N02 RAISED AGAINST EAEC T6SS TSSM
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 4qlr_B
References	NGUYEN S., LOGGER L., SPINELLI S., DESMYTER A., LE T., KELLENBERGER C., DOUZI B., DURAND E., ROUSSEL A., CASCALES E., CAMBILLAU C. 'INHIBITION OF TYPE VI SECRETION BY AN ANTI-TSSM LLAMA NANOBODY.' PLOS ONE V. 10 22187 2015 ESSN 1932-6203

Tools

Sequences

Amino Acid Sequence:

DVQLVESGGGLVHPGGSLRLSCAASGRTFSDYALGWFRQAPGKDREFVAAISWSGGSTYY
ADSVQGRFTISRDNDKNSVYLQMNSLKPEDTAVYYCAADKYYTGPGGESVYDYWGRGTQV
TVSSHHHHHH