abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	A	1 - 1	1
HFR1	QVQLQESGGGLVQAGGSLRLSCAASERTFS	2 - 31	30
CDR-H1	TYAMG	32 - 36	5
HFR2	WFRQAPGREREFLA	37 - 50	14
CDR-H2	QINWSGTTTYYAESVKD	51 - 67	17
HFR3	RTTISRDNAKNTVYLEMNNLNADDTGIYFCAA	68 - 99	32
CDR-H3	HPQRGWGSTLGWTY	100 - 113	14
HFR4	WGQGTQVTVSS	114 - 124	11
Tail	GGGGSGGGKPIPNPLLGLDSTRTGHHHHHH	124 - 154	30
			154

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQAGGSLRLSCAAS-----	2 - 26	25
	AbM	QVQLQESGGGLVQAGGSLRLSCAAS-----	2 - 26	25
	Kabat	QVQLQESGGGLVQAGGSLRLSCAASERTFS	2 - 31	30
	Contact	QVQLQESGGGLVQAGGSLRLSCAASERTF-	2 - 30	29
	IMGT	QVQLQESGGGLVQAGGSLRLSCAAS-----	2 - 26	25
CDR-H1	Chothia	ERTFSTY---	27 - 33	7
	AbM	ERTFSTYAMG	27 - 36	10
	Kabat	-----TYAMG	32 - 36	5
	Contact	----STYAMG	31 - 36	6
	IMGT	ERTFSTYA--	27 - 34	8
HFR2	Chothia	AMGWFRQAPGREREFLAQI	34 - 52	19
	AbM	---WFRQAPGREREFLA--	37 - 50	14
	Kabat	---WFRQAPGREREFLA--	37 - 50	14
	Contact	---WFRQAPGRERE-----	37 - 47	11
	IMGT	-MGWFRQAPGREREFLAQ-	35 - 51	17
CDR-H2	Chothia	-----NWSGTT---------	53 - 58	6
	AbM	---QINWSGTTTY-------	51 - 60	10
	Kabat	---QINWSGTTTYYAESVKD	51 - 67	17
	Contact	FLAQINWSGTTTY-------	48 - 60	13
	IMGT	----INWSGTTT--------	52 - 59	8
HFR3	Chothia	TYYAESVKDRTTISRDNAKNTVYLEMNNLNADDTGIYFCAA	59 - 99	41
	AbM	--YAESVKDRTTISRDNAKNTVYLEMNNLNADDTGIYFCAA	61 - 99	39
	Kabat	---------RTTISRDNAKNTVYLEMNNLNADDTGIYFCAA	68 - 99	32
	Contact	--YAESVKDRTTISRDNAKNTVYLEMNNLNADDTGIYFC--	61 - 97	37
	IMGT	-YYAESVKDRTTISRDNAKNTVYLEMNNLNADDTGIYFC--	60 - 97	38
CDR-H3	Chothia	--HPQRGWGSTLGWTY	100 - 113	14
	AbM	--HPQRGWGSTLGWTY	100 - 113	14
	Kabat	--HPQRGWGSTLGWTY	100 - 113	14
	Contact	AAHPQRGWGSTLGWT-	98 - 112	15
	IMGT	AAHPQRGWGSTLGWTY	98 - 113	16
HFR4	Chothia	-WGQGTQVTVSS	114 - 124	11
	AbM	-WGQGTQVTVSS	114 - 124	11
	Kabat	-WGQGTQVTVSS	114 - 124	11
	Contact	YWGQGTQVTVSS	113 - 124	12
	IMGT	-WGQGTQVTVSS	114 - 124	11

Accession & Annotations

Accession	4qo1_A
Source	PDB 4qo1 Submitted 19-JUN-2014 Updated 26-NOV-2014
Name	P53 DNA BINDING DOMAIN IN COMPLEX WITH NB139
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	BETHUYNE J., DE GIETER S., ZWAENEPOEL O., GARCIA-PINO A., DURINCK K., VERHELLE A., HASSANZADEH-GHASSABEH G., SPELEMAN F., LORIS R., GETTEMANS J. 'A NANOBODY MODULATES THE P53 TRANSCRIPTIONAL PROGRAM WITHOUT PERTURBING ITS FUNCTIONAL ARCHITECTURE.' NUCLEIC ACIDS RES. V. 42 12928 2014 ISSN 0305-1048

Tools

Sequences

Amino Acid Sequence:

AQVQLQESGGGLVQAGGSLRLSCAASERTFSTYAMGWFRQAPGREREFLAQINWSGTTTY
YAESVKDRTTISRDNAKNTVYLEMNNLNADDTGIYFCAAHPQRGWGSTLGWTYWGQGTQV
TVSSGGGGSGGGKPIPNPLLGLDSTRTGHHHHHH

Data Source:

Alignment settings:

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