abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQAGGSLRLSCAASGRTFS	1 - 30	30
CDR-H1	SFVMG	31 - 35	5
HFR2	WFRQAPGKEREFVA	36 - 49	14
CDR-H2	SISRSGSVTRYADSAKG	50 - 66	17
HFR3	RFTISKDNAKNTVSLQMDNLNPDDTAVYYCAA	67 - 98	32
CDR-H3	DLHRPYGPGSQRTDDYDT	99 - 116	18
HFR4	WGQGTQVTVSS	117 - 127	11
			127

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGLVQAGGSLRLSCAASGRTFS	1 - 30	30
	Contact	QVQLQESGGGLVQAGGSLRLSCAASGRTF-	1 - 29	29
	IMGT	QVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GRTFSSF---	26 - 32	7
	AbM	GRTFSSFVMG	26 - 35	10
	Kabat	-----SFVMG	31 - 35	5
	Contact	----SSFVMG	30 - 35	6
	IMGT	GRTFSSFV--	26 - 33	8
HFR2	Chothia	VMGWFRQAPGKEREFVASI	33 - 51	19
	AbM	---WFRQAPGKEREFVA--	36 - 49	14
	Kabat	---WFRQAPGKEREFVA--	36 - 49	14
	Contact	---WFRQAPGKERE-----	36 - 46	11
	IMGT	-MGWFRQAPGKEREFVAS-	34 - 50	17
CDR-H2	Chothia	-----SRSGSV---------	52 - 57	6
	AbM	---SISRSGSVTR-------	50 - 59	10
	Kabat	---SISRSGSVTRYADSAKG	50 - 66	17
	Contact	FVASISRSGSVTR-------	47 - 59	13
	IMGT	----ISRSGSVT--------	51 - 58	8
HFR3	Chothia	TRYADSAKGRFTISKDNAKNTVSLQMDNLNPDDTAVYYCAA	58 - 98	41
	AbM	--YADSAKGRFTISKDNAKNTVSLQMDNLNPDDTAVYYCAA	60 - 98	39
	Kabat	---------RFTISKDNAKNTVSLQMDNLNPDDTAVYYCAA	67 - 98	32
	Contact	--YADSAKGRFTISKDNAKNTVSLQMDNLNPDDTAVYYC--	60 - 96	37
	IMGT	-RYADSAKGRFTISKDNAKNTVSLQMDNLNPDDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--DLHRPYGPGSQRTDDYDT	99 - 116	18
	AbM	--DLHRPYGPGSQRTDDYDT	99 - 116	18
	Kabat	--DLHRPYGPGSQRTDDYDT	99 - 116	18
	Contact	AADLHRPYGPGSQRTDDYD-	97 - 115	19
	IMGT	AADLHRPYGPGSQRTDDYDT	97 - 116	20
HFR4	Chothia	-WGQGTQVTVSS	117 - 127	11
	AbM	-WGQGTQVTVSS	117 - 127	11
	Kabat	-WGQGTQVTVSS	117 - 127	11
	Contact	TWGQGTQVTVSS	116 - 127	12
	IMGT	-WGQGTQVTVSS	117 - 127	11

Accession & Annotations

Accession	4s10_B
Source	PDB 4s10 Submitted 07-JAN-2015 Updated 03-JUN-2015
Name	GELSOLIN NANOBODY SHIELDING MUTANT PLASMA GELSOLIN FROM FURIN PROTEOLYSIS
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 4s10_A
References	VAN OVERBEKE W., WONGSANTICHON J., EVERAERT I., VERHELLE A., ZWAENEPOEL O., LOONCHANTA A., BURTNICK D., DE GANCK A., HOCHEPIED T., HAIGH J., CUVELIER C., DERAVE W., ROBINSON C., GETTEMANS J. 'AN ER-DIRECTED GELSOLIN NANOBODY TARGETS THE FIRST STEP IN AMYLOID FORMATION IN A GELSOLIN AMYLOIDOSIS MOUSE MODEL.' HUM.MOL.GENET. V. 24 2492 2015 ISSN 0964-6906

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQAGGSLRLSCAASGRTFSSFVMGWFRQAPGKEREFVASISRSGSVTRY
ADSAKGRFTISKDNAKNTVSLQMDNLNPDDTAVYYCAADLHRPYGPGSQRTDDYDTWGQG
TQVTVSS