abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGSVQAGGSLRLSCAASGYTSG	1 - 30	30
CDR-H1	RDSMG	31 - 35	5
HFR2	WFRQAPGKEREGVA	36 - 49	14
CDR-H2	CIDTSGIVNYADSVKG	50 - 65	16
HFR3	RFTISQDSAKKTLYLEMNSLKPEDTALYSCAT	66 - 97	32
CDR-H3	GPFVYGRGCLGQAFYSY	98 - 114	17
HFR4	WGQGTQVTVSS	115 - 125	11
Tail	HHHHHH	125 - 131	6
			131

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGSVQAGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGSVQAGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGSVQAGGSLRLSCAASGYTSG	1 - 30	30
	Contact	QVQLQESGGGSVQAGGSLRLSCAASGYTS-	1 - 29	29
	IMGT	QVQLQESGGGSVQAGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GYTSGRD---	26 - 32	7
	AbM	GYTSGRDSMG	26 - 35	10
	Kabat	-----RDSMG	31 - 35	5
	Contact	----GRDSMG	30 - 35	6
	IMGT	GYTSGRDS--	26 - 33	8
HFR2	Chothia	SMGWFRQAPGKEREGVACI	33 - 51	19
	AbM	---WFRQAPGKEREGVA--	36 - 49	14
	Kabat	---WFRQAPGKEREGVA--	36 - 49	14
	Contact	---WFRQAPGKERE-----	36 - 46	11
	IMGT	-MGWFRQAPGKEREGVAC-	34 - 50	17
CDR-H2	Chothia	-----DTSGI---------	52 - 56	5
	AbM	---CIDTSGIVN-------	50 - 58	9
	Kabat	---CIDTSGIVNYADSVKG	50 - 65	16
	Contact	GVACIDTSGIVN-------	47 - 58	12
	IMGT	----IDTSGIV--------	51 - 57	7
HFR3	Chothia	VNYADSVKGRFTISQDSAKKTLYLEMNSLKPEDTALYSCAT	57 - 97	41
	AbM	--YADSVKGRFTISQDSAKKTLYLEMNSLKPEDTALYSCAT	59 - 97	39
	Kabat	---------RFTISQDSAKKTLYLEMNSLKPEDTALYSCAT	66 - 97	32
	Contact	--YADSVKGRFTISQDSAKKTLYLEMNSLKPEDTALYSC--	59 - 95	37
	IMGT	-NYADSVKGRFTISQDSAKKTLYLEMNSLKPEDTALYSC--	58 - 95	38
CDR-H3	Chothia	--GPFVYGRGCLGQAFYSY	98 - 114	17
	AbM	--GPFVYGRGCLGQAFYSY	98 - 114	17
	Kabat	--GPFVYGRGCLGQAFYSY	98 - 114	17
	Contact	ATGPFVYGRGCLGQAFYS-	96 - 113	18
	IMGT	ATGPFVYGRGCLGQAFYSY	96 - 114	19
HFR4	Chothia	-WGQGTQVTVSS	115 - 125	11
	AbM	-WGQGTQVTVSS	115 - 125	11
	Kabat	-WGQGTQVTVSS	115 - 125	11
	Contact	YWGQGTQVTVSS	114 - 125	12
	IMGT	-WGQGTQVTVSS	115 - 125	11

Accession & Annotations

Accession	4w6w_B
Source	PDB 4w6w Submitted 21-AUG-2014 Updated 07-FEB-2018
Name	CO-COMPLEX STRUCTURE OF THE LECTIN DOMAIN OF F18 FIMBRIAL ADHESIN FEDF WITH INHIBITORY NANOBODY NBFEDF6
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	MOONENS K., DE KERPEL M., CODDENS A., COX E., PARDON E., REMAUT H., DE GREVE H. 'NANOBODY MEDIATED INHIBITION OF ATTACHMENT OF F18 FIMBRIAE EXPRESSING ESCHERICHIA COLI.' PLOS ONE V. 9 14691 2014 ESSN 1932-6203

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGSVQAGGSLRLSCAASGYTSGRDSMGWFRQAPGKEREGVACIDTSGIVNYA
DSVKGRFTISQDSAKKTLYLEMNSLKPEDTALYSCATGPFVYGRGCLGQAFYSYWGQGTQ
VTVSSHHHHHH