abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGSVQAGGSLRLSCAASGYTYS	1 - 30	30
CDR-H1	SNCMA	31 - 35	5
HFR2	WFRQVPGKEREGVA	36 - 49	14
CDR-H2	SINTRGGITYYADSVKG	50 - 66	17
HFR3	RFTISRDNAKNTVSLQMNSLKPEDTATYYCAA	67 - 98	32
CDR-H3	VREATYSDNRCSVRSYTYDY	99 - 118	20
HFR4	WGQGTQVTVSS	119 - 129	11
Tail	HHHHHH	129 - 135	6
			135

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGSVQAGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGSVQAGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGSVQAGGSLRLSCAASGYTYS	1 - 30	30
	Contact	QVQLQESGGGSVQAGGSLRLSCAASGYTY-	1 - 29	29
	IMGT	QVQLQESGGGSVQAGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GYTYSSN---	26 - 32	7
	AbM	GYTYSSNCMA	26 - 35	10
	Kabat	-----SNCMA	31 - 35	5
	Contact	----SSNCMA	30 - 35	6
	IMGT	GYTYSSNC--	26 - 33	8
HFR2	Chothia	CMAWFRQVPGKEREGVASI	33 - 51	19
	AbM	---WFRQVPGKEREGVA--	36 - 49	14
	Kabat	---WFRQVPGKEREGVA--	36 - 49	14
	Contact	---WFRQVPGKERE-----	36 - 46	11
	IMGT	-MAWFRQVPGKEREGVAS-	34 - 50	17
CDR-H2	Chothia	-----NTRGGI---------	52 - 57	6
	AbM	---SINTRGGITY-------	50 - 59	10
	Kabat	---SINTRGGITYYADSVKG	50 - 66	17
	Contact	GVASINTRGGITY-------	47 - 59	13
	IMGT	----INTRGGIT--------	51 - 58	8
HFR3	Chothia	TYYADSVKGRFTISRDNAKNTVSLQMNSLKPEDTATYYCAA	58 - 98	41
	AbM	--YADSVKGRFTISRDNAKNTVSLQMNSLKPEDTATYYCAA	60 - 98	39
	Kabat	---------RFTISRDNAKNTVSLQMNSLKPEDTATYYCAA	67 - 98	32
	Contact	--YADSVKGRFTISRDNAKNTVSLQMNSLKPEDTATYYC--	60 - 96	37
	IMGT	-YYADSVKGRFTISRDNAKNTVSLQMNSLKPEDTATYYC--	59 - 96	38
CDR-H3	Chothia	--VREATYSDNRCSVRSYTYDY	99 - 118	20
	AbM	--VREATYSDNRCSVRSYTYDY	99 - 118	20
	Kabat	--VREATYSDNRCSVRSYTYDY	99 - 118	20
	Contact	AAVREATYSDNRCSVRSYTYD-	97 - 117	21
	IMGT	AAVREATYSDNRCSVRSYTYDY	97 - 118	22
HFR4	Chothia	-WGQGTQVTVSS	119 - 129	11
	AbM	-WGQGTQVTVSS	119 - 129	11
	Kabat	-WGQGTQVTVSS	119 - 129	11
	Contact	YWGQGTQVTVSS	118 - 129	12
	IMGT	-WGQGTQVTVSS	119 - 129	11

Accession & Annotations

Accession	4w6y_B
Source	PDB 4w6y Submitted 21-AUG-2014 Updated 07-MAR-2018
Name	CO-COMPLEX STRUCTURE OF THE LECTIN DOMAIN OF F18 FIMBRIAL ADHESIN FEDF WITH INHIBITORY NANOBODY NBFEDF9
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	MOONENS K., DE KERPEL M., CODDENS A., COX E., PARDON E., REMAUT H., DE GREVE H. 'NANOBODY MEDIATED INHIBITION OF ATTACHMENT OF F18 FIMBRIAE EXPRESSING ESCHERICHIA COLI.' PLOS ONE V. 9 14691 2014 ESSN 1932-6203

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGSVQAGGSLRLSCAASGYTYSSNCMAWFRQVPGKEREGVASINTRGGITYY
ADSVKGRFTISRDNAKNTVSLQMNSLKPEDTATYYCAAVREATYSDNRCSVRSYTYDYWG
QGTQVTVSSHHHHHH