abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	DVQLVESGGGLVQPGGSLRLSCAASESILS	1 - 30	30
CDR-H1	FNHMA	31 - 35	5
HFR2	WYRQGPGEQRELVA	36 - 49	14
CDR-H2	VITREGSTDYADSVKG	50 - 65	16
HFR3	RFTISRDNAKNMVYLLMSNLRPEDTAVYYCNR	66 - 97	32
CDR-H3	GISNP	98 - 102	5
HFR4	WGQGTQVTVSS	103 - 113	11
Tail	HHHHHH	113 - 119	6
			119

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	DVQLVESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	AbM	DVQLVESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	Kabat	DVQLVESGGGLVQPGGSLRLSCAASESILS	1 - 30	30
	Contact	DVQLVESGGGLVQPGGSLRLSCAASESIL-	1 - 29	29
	IMGT	DVQLVESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	ESILSFN---	26 - 32	7
	AbM	ESILSFNHMA	26 - 35	10
	Kabat	-----FNHMA	31 - 35	5
	Contact	----SFNHMA	30 - 35	6
	IMGT	ESILSFNH--	26 - 33	8
HFR2	Chothia	HMAWYRQGPGEQRELVAVI	33 - 51	19
	AbM	---WYRQGPGEQRELVA--	36 - 49	14
	Kabat	---WYRQGPGEQRELVA--	36 - 49	14
	Contact	---WYRQGPGEQRE-----	36 - 46	11
	IMGT	-MAWYRQGPGEQRELVAV-	34 - 50	17
CDR-H2	Chothia	-----TREGS---------	52 - 56	5
	AbM	---VITREGSTD-------	50 - 58	9
	Kabat	---VITREGSTDYADSVKG	50 - 65	16
	Contact	LVAVITREGSTD-------	47 - 58	12
	IMGT	----ITREGST--------	51 - 57	7
HFR3	Chothia	TDYADSVKGRFTISRDNAKNMVYLLMSNLRPEDTAVYYCNR	57 - 97	41
	AbM	--YADSVKGRFTISRDNAKNMVYLLMSNLRPEDTAVYYCNR	59 - 97	39
	Kabat	---------RFTISRDNAKNMVYLLMSNLRPEDTAVYYCNR	66 - 97	32
	Contact	--YADSVKGRFTISRDNAKNMVYLLMSNLRPEDTAVYYC--	59 - 95	37
	IMGT	-DYADSVKGRFTISRDNAKNMVYLLMSNLRPEDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--GISNP	98 - 102	5
	AbM	--GISNP	98 - 102	5
	Kabat	--GISNP	98 - 102	5
	Contact	NRGISN-	96 - 101	6
	IMGT	NRGISNP	96 - 102	7
HFR4	Chothia	-WGQGTQVTVSS	103 - 113	11
	AbM	-WGQGTQVTVSS	103 - 113	11
	Kabat	-WGQGTQVTVSS	103 - 113	11
	Contact	PWGQGTQVTVSS	102 - 113	12
	IMGT	-WGQGTQVTVSS	103 - 113	11

Accession & Annotations

Accession	4x7f_D
Source	PDB 4x7f Submitted 09-DEC-2014 Updated 10-APR-2019
Name	CRYSTAL STRUCTURE OF NOROVIRUS GII.10 P DOMAIN IN COMPLEX WITH NANO-25
Organism	Vicugna pacos
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 4x7f_C
References	KOROMYSLOVA D., HANSMAN S. 'NANOBODY BINDING TO A CONSERVED EPITOPE PROMOTES NOROVIRUS PARTICLE DISASSEMBLY.' J.VIROL. V. 89 2718 2015 ESSN 1098-5514

Tools

Sequences

Amino Acid Sequence:

DVQLVESGGGLVQPGGSLRLSCAASESILSFNHMAWYRQGPGEQRELVAVITREGSTDYA
DSVKGRFTISRDNAKNMVYLLMSNLRPEDTAVYYCNRGISNPWGQGTQVTVSSHHHHHH