abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	GPGS	1 - 4	4
HFR1	QVQLVESGGGLVRPGGSLRLSCAASGSIFT	5 - 34	30
CDR-H1	IYAMG	35 - 39	5
HFR2	WYRQAPGKQRELVA	40 - 53	14
CDR-H2	RITFGGDTNYADSVKG	54 - 69	16
HFR3	RFTISRDNAKNAVYLQMNSLKPEDTAVYYCNA	70 - 101	32
CDR-H3	EETIVEEADY	102 - 111	10
HFR4	WGQGTQVTVSS	112 - 122	11
Tail	RAAAHHHHHHHH	122 - 134	12
			134

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLVESGGGLVRPGGSLRLSCAAS-----	5 - 29	25
	AbM	QVQLVESGGGLVRPGGSLRLSCAAS-----	5 - 29	25
	Kabat	QVQLVESGGGLVRPGGSLRLSCAASGSIFT	5 - 34	30
	Contact	QVQLVESGGGLVRPGGSLRLSCAASGSIF-	5 - 33	29
	IMGT	QVQLVESGGGLVRPGGSLRLSCAAS-----	5 - 29	25
CDR-H1	Chothia	GSIFTIY---	30 - 36	7
	AbM	GSIFTIYAMG	30 - 39	10
	Kabat	-----IYAMG	35 - 39	5
	Contact	----TIYAMG	34 - 39	6
	IMGT	GSIFTIYA--	30 - 37	8
HFR2	Chothia	AMGWYRQAPGKQRELVARI	37 - 55	19
	AbM	---WYRQAPGKQRELVA--	40 - 53	14
	Kabat	---WYRQAPGKQRELVA--	40 - 53	14
	Contact	---WYRQAPGKQRE-----	40 - 50	11
	IMGT	-MGWYRQAPGKQRELVAR-	38 - 54	17
CDR-H2	Chothia	-----TFGGD---------	56 - 60	5
	AbM	---RITFGGDTN-------	54 - 62	9
	Kabat	---RITFGGDTNYADSVKG	54 - 69	16
	Contact	LVARITFGGDTN-------	51 - 62	12
	IMGT	----ITFGGDT--------	55 - 61	7
HFR3	Chothia	TNYADSVKGRFTISRDNAKNAVYLQMNSLKPEDTAVYYCNA	61 - 101	41
	AbM	--YADSVKGRFTISRDNAKNAVYLQMNSLKPEDTAVYYCNA	63 - 101	39
	Kabat	---------RFTISRDNAKNAVYLQMNSLKPEDTAVYYCNA	70 - 101	32
	Contact	--YADSVKGRFTISRDNAKNAVYLQMNSLKPEDTAVYYC--	63 - 99	37
	IMGT	-NYADSVKGRFTISRDNAKNAVYLQMNSLKPEDTAVYYC--	62 - 99	38
CDR-H3	Chothia	--EETIVEEADY	102 - 111	10
	AbM	--EETIVEEADY	102 - 111	10
	Kabat	--EETIVEEADY	102 - 111	10
	Contact	NAEETIVEEAD-	100 - 110	11
	IMGT	NAEETIVEEADY	100 - 111	12
HFR4	Chothia	-WGQGTQVTVSS	112 - 122	11
	AbM	-WGQGTQVTVSS	112 - 122	11
	Kabat	-WGQGTQVTVSS	112 - 122	11
	Contact	YWGQGTQVTVSS	111 - 122	12
	IMGT	-WGQGTQVTVSS	112 - 122	11

Accession & Annotations

Accession	4xt1_C
Source	PDB 4xt1 Submitted 22-JAN-2015 Updated 18-MAR-2015
Name	STRUCTURE OF A NANOBODY-BOUND VIRAL GPCR BOUND TO HUMAN CHEMOKINE CX3CL1
Organism	Vicugna pacos
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	BURG S., INGRAM R., VENKATAKRISHNAN J., JUDE M., DUKKIPATI A., FEINBERG N., ANGELINI A., WAGHRAY D., DROR O., PLOEGH L., GARCIA C. 'STRUCTURAL BIOLOGY. STRUCTURAL BASIS FOR CHEMOKINE RECOGNITION AND ACTIVATION OF A VIRAL G PROTEIN-COUPLED RECEPTOR.' SCIENCE V. 347 1113 2015 ESSN 1095-9203

Tools

Sequences

Amino Acid Sequence:

GPGSQVQLVESGGGLVRPGGSLRLSCAASGSIFTIYAMGWYRQAPGKQRELVARITFGGD
TNYADSVKGRFTISRDNAKNAVYLQMNSLKPEDTAVYYCNAEETIVEEADYWGQGTQVTV
SSRAAAHHHHHHHH