abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQAGGSLRLSCAASGGTFS	1 - 30	30
CDR-H1	TYGMG	31 - 35	5
HFR2	WFRQAPGKEREFVA	36 - 49	14
CDR-H2	ASSWTGANTYYADSVRG	50 - 66	17
HFR3	RFTISRDNAKNTVYLEMNSLKPEDTAVYYCAA	67 - 98	32
CDR-H3	RRWLGGSYFDPGNYDF	99 - 114	16
HFR4	WGQGTQVTVSS	115 - 125	11
Tail	HHHHHHEPEA	125 - 135	10
			135

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGLVQAGGSLRLSCAASGGTFS	1 - 30	30
	Contact	QVQLQESGGGLVQAGGSLRLSCAASGGTF-	1 - 29	29
	IMGT	QVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GGTFSTY---	26 - 32	7
	AbM	GGTFSTYGMG	26 - 35	10
	Kabat	-----TYGMG	31 - 35	5
	Contact	----STYGMG	30 - 35	6
	IMGT	GGTFSTYG--	26 - 33	8
HFR2	Chothia	GMGWFRQAPGKEREFVAAS	33 - 51	19
	AbM	---WFRQAPGKEREFVA--	36 - 49	14
	Kabat	---WFRQAPGKEREFVA--	36 - 49	14
	Contact	---WFRQAPGKERE-----	36 - 46	11
	IMGT	-MGWFRQAPGKEREFVAA-	34 - 50	17
CDR-H2	Chothia	-----SWTGAN---------	52 - 57	6
	AbM	---ASSWTGANTY-------	50 - 59	10
	Kabat	---ASSWTGANTYYADSVRG	50 - 66	17
	Contact	FVAASSWTGANTY-------	47 - 59	13
	IMGT	----SSWTGANT--------	51 - 58	8
HFR3	Chothia	TYYADSVRGRFTISRDNAKNTVYLEMNSLKPEDTAVYYCAA	58 - 98	41
	AbM	--YADSVRGRFTISRDNAKNTVYLEMNSLKPEDTAVYYCAA	60 - 98	39
	Kabat	---------RFTISRDNAKNTVYLEMNSLKPEDTAVYYCAA	67 - 98	32
	Contact	--YADSVRGRFTISRDNAKNTVYLEMNSLKPEDTAVYYC--	60 - 96	37
	IMGT	-YYADSVRGRFTISRDNAKNTVYLEMNSLKPEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--RRWLGGSYFDPGNYDF	99 - 114	16
	AbM	--RRWLGGSYFDPGNYDF	99 - 114	16
	Kabat	--RRWLGGSYFDPGNYDF	99 - 114	16
	Contact	AARRWLGGSYFDPGNYD-	97 - 113	17
	IMGT	AARRWLGGSYFDPGNYDF	97 - 114	18
HFR4	Chothia	-WGQGTQVTVSS	115 - 125	11
	AbM	-WGQGTQVTVSS	115 - 125	11
	Kabat	-WGQGTQVTVSS	115 - 125	11
	Contact	FWGQGTQVTVSS	114 - 125	12
	IMGT	-WGQGTQVTVSS	115 - 125	11

Accession & Annotations

Accession	5bop_C
Source	PDB 5bop Submitted 27-MAY-2015 Updated 08-JUN-2016
Name	CRYSTAL STRUCTURE OF THE ARTIFICIAL NANOBODY OCTARELLINV.1 COMPLEX
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 5bop_A
References	FIGUEROA M., SLEUTEL M., VANDEVENNE M., PARVIZI G., ATTOUT S., JACQUIN O., VANDENAMEELE J., FISCHER W., DAMBLON C., GOORMAGHTIGH E., VALERIO-LEPINIEC M., URVOAS A., DURAND D., PARDON E., STEYAERT J., MINARD P., MAES D., MEILER J., MATAGNE A., MARTIAL A., VAN DE WEERDT C. 'THE UNEXPECTED STRUCTURE OF THE DESIGNED PROTEIN OCTARELLIN V.1 FORMS A CHALLENGE FOR PROTEIN STRUCTURE PREDICTION TOOLS.' J.STRUCT.BIOL. V. 195 19 2016 ESSN 1095-8657

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQAGGSLRLSCAASGGTFSTYGMGWFRQAPGKEREFVAASSWTGANTYY
ADSVRGRFTISRDNAKNTVYLEMNSLKPEDTAVYYCAARRWLGGSYFDPGNYDFWGQGTQ
VTVSSHHHHHHEPEA