abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	NM	1 - 2	2
HFR1	QVQLVESGGGLVQAGGSLRLSCAASGRTFS	3 - 32	30
CDR-H1	RSSMG	33 - 37	5
HFR2	WFRQAPGKEREFVA	38 - 51	14
CDR-H2	SIVWADGTTLYGDSVKG	52 - 68	17
HFR3	RFTVSRDNVKNMVYLQMNNLKPEDTALYYCAD	69 - 100	32
CDR-H3	NKFVRGLVAVRAIDYDY	101 - 117	17
HFR4	WGQGTQVTVS	118 - 127	10
			127

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLVESGGGLVQAGGSLRLSCAAS-----	3 - 27	25
	AbM	QVQLVESGGGLVQAGGSLRLSCAAS-----	3 - 27	25
	Kabat	QVQLVESGGGLVQAGGSLRLSCAASGRTFS	3 - 32	30
	Contact	QVQLVESGGGLVQAGGSLRLSCAASGRTF-	3 - 31	29
	IMGT	QVQLVESGGGLVQAGGSLRLSCAAS-----	3 - 27	25
CDR-H1	Chothia	GRTFSRS---	28 - 34	7
	AbM	GRTFSRSSMG	28 - 37	10
	Kabat	-----RSSMG	33 - 37	5
	Contact	----SRSSMG	32 - 37	6
	IMGT	GRTFSRSS--	28 - 35	8
HFR2	Chothia	SMGWFRQAPGKEREFVASI	35 - 53	19
	AbM	---WFRQAPGKEREFVA--	38 - 51	14
	Kabat	---WFRQAPGKEREFVA--	38 - 51	14
	Contact	---WFRQAPGKERE-----	38 - 48	11
	IMGT	-MGWFRQAPGKEREFVAS-	36 - 52	17
CDR-H2	Chothia	-----VWADGT---------	54 - 59	6
	AbM	---SIVWADGTTL-------	52 - 61	10
	Kabat	---SIVWADGTTLYGDSVKG	52 - 68	17
	Contact	FVASIVWADGTTL-------	49 - 61	13
	IMGT	----IVWADGTT--------	53 - 60	8
HFR3	Chothia	TLYGDSVKGRFTVSRDNVKNMVYLQMNNLKPEDTALYYCAD	60 - 100	41
	AbM	--YGDSVKGRFTVSRDNVKNMVYLQMNNLKPEDTALYYCAD	62 - 100	39
	Kabat	---------RFTVSRDNVKNMVYLQMNNLKPEDTALYYCAD	69 - 100	32
	Contact	--YGDSVKGRFTVSRDNVKNMVYLQMNNLKPEDTALYYC--	62 - 98	37
	IMGT	-LYGDSVKGRFTVSRDNVKNMVYLQMNNLKPEDTALYYC--	61 - 98	38
CDR-H3	Chothia	--NKFVRGLVAVRAIDYDY	101 - 117	17
	AbM	--NKFVRGLVAVRAIDYDY	101 - 117	17
	Kabat	--NKFVRGLVAVRAIDYDY	101 - 117	17
	Contact	ADNKFVRGLVAVRAIDYD-	99 - 116	18
	IMGT	ADNKFVRGLVAVRAIDYDY	99 - 117	19
HFR4	Chothia	-WGQGTQVTVS	118 - 127	10
	AbM	-WGQGTQVTVS	118 - 127	10
	Kabat	-WGQGTQVTVS	118 - 127	10
	Contact	YWGQGTQVTVS	117 - 127	11
	IMGT	-WGQGTQVTVS	118 - 127	10

Accession & Annotations

Accession	5boz_H
Source	PDB 5boz Submitted 27-MAY-2015 Updated 13-SEP-2017
Name	RICIN A CHAIN BOUND TO CAMELID NANOBODY (VHH9)(E1)
Organism	Vicugna pacos
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 5boz_G 5boz_I 5boz_J 5boz_K 5boz_L
References	RUDOLPH J., VANCE J., CASSIDY S., RONG Y., MANTIS J. 'STRUCTURAL ANALYSIS OF SINGLE DOMAIN ANTIBODIES BOUND TO A SECOND NEUTRALIZING HOT SPOT ON RICIN TOXIN'S ENZYMATIC SUBUNIT.' J. BIOL. CHEM. V. 292 872 2017 ESSN 1083-351X

Tools

Sequences

Amino Acid Sequence:

NMQVQLVESGGGLVQAGGSLRLSCAASGRTFSRSSMGWFRQAPGKEREFVASIVWADGTT
LYGDSVKGRFTVSRDNVKNMVYLQMNNLKPEDTALYYCADNKFVRGLVAVRAIDYDYWGQ
GTQVTVS