abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLVESGGGLVRPGGSLRLSCVDSERTS	1 - 29	29
CDR-H1	YPMG	30 - 33	4
HFR2	WFRRAPGKEREFVA	34 - 47	14
CDR-H2	SITWSGIDPTYADSVAD	48 - 64	17
HFR3	RFTTSRDVANNTLYLQMNSLKHEDTAVYYCAA	65 - 96	32
CDR-H3	RAPVGQSSSPYDYDY	97 - 111	15
HFR4	WGQGTQVTVSS	112 - 122	11
Tail	AAA	122 - 125	3
			125

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLVESGGGLVRPGGSLRLSCVDS----	1 - 25	25
	AbM	QVQLVESGGGLVRPGGSLRLSCVDS----	1 - 25	25
	Kabat	QVQLVESGGGLVRPGGSLRLSCVDSERTS	1 - 29	29
	Contact	QVQLVESGGGLVRPGGSLRLSCVDSERTS	1 - 29	29
	IMGT	QVQLVESGGGLVRPGGSLRLSCVDS----	1 - 25	25
CDR-H1	Chothia	ERTSY---	26 - 30	5
	AbM	ERTSYPMG	26 - 33	8
	Kabat	----YPMG	30 - 33	4
	Contact	----YPMG	30 - 33	4
	IMGT	ERTSYP--	26 - 31	6
HFR2	Chothia	PMGWFRRAPGKEREFVASI	31 - 49	19
	AbM	---WFRRAPGKEREFVA--	34 - 47	14
	Kabat	---WFRRAPGKEREFVA--	34 - 47	14
	Contact	---WFRRAPGKERE-----	34 - 44	11
	IMGT	-MGWFRRAPGKEREFVAS-	32 - 48	17
CDR-H2	Chothia	-----TWSGID---------	50 - 55	6
	AbM	---SITWSGIDPT-------	48 - 57	10
	Kabat	---SITWSGIDPTYADSVAD	48 - 64	17
	Contact	FVASITWSGIDPT-------	45 - 57	13
	IMGT	----ITWSGIDP--------	49 - 56	8
HFR3	Chothia	PTYADSVADRFTTSRDVANNTLYLQMNSLKHEDTAVYYCAA	56 - 96	41
	AbM	--YADSVADRFTTSRDVANNTLYLQMNSLKHEDTAVYYCAA	58 - 96	39
	Kabat	---------RFTTSRDVANNTLYLQMNSLKHEDTAVYYCAA	65 - 96	32
	Contact	--YADSVADRFTTSRDVANNTLYLQMNSLKHEDTAVYYC--	58 - 94	37
	IMGT	-TYADSVADRFTTSRDVANNTLYLQMNSLKHEDTAVYYC--	57 - 94	38
CDR-H3	Chothia	--RAPVGQSSSPYDYDY	97 - 111	15
	AbM	--RAPVGQSSSPYDYDY	97 - 111	15
	Kabat	--RAPVGQSSSPYDYDY	97 - 111	15
	Contact	AARAPVGQSSSPYDYD-	95 - 110	16
	IMGT	AARAPVGQSSSPYDYDY	95 - 111	17
HFR4	Chothia	-WGQGTQVTVSS	112 - 122	11
	AbM	-WGQGTQVTVSS	112 - 122	11
	Kabat	-WGQGTQVTVSS	112 - 122	11
	Contact	YWGQGTQVTVSS	111 - 122	12
	IMGT	-WGQGTQVTVSS	112 - 122	11

Accession & Annotations

Accession	5c1m_B
Source	PDB 5c1m Submitted 15-JUN-2015 Updated 06-SEP-2017
Name	CRYSTAL STRUCTURE OF ACTIVE MU-OPIOID RECEPTOR BOUND TO THE AGONIST BU72
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	HUANG W., MANGLIK A., VENKATAKRISHNAN J., LAEREMANS T., FEINBERG N., SANBORN L., KATO E., LIVINGSTON E., THORSEN S., KLING C., GRANIER S., GMEINER P., HUSBANDS M., TRAYNOR R., WEIS I., STEYAERT J., DROR O., KOBILKA K. 'STRUCTURAL INSIGHTS INTO MU-OPIOID RECEPTOR ACTIVATION.' NATURE V. 524 315 2015 ESSN 1476-4687

Tools

Sequences

Amino Acid Sequence:

QVQLVESGGGLVRPGGSLRLSCVDSERTSYPMGWFRRAPGKEREFVASITWSGIDPTYAD
SVADRFTTSRDVANNTLYLQMNSLKHEDTAVYYCAARAPVGQSSSPYDYDYWGQGTQVTV
SSAAA