abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	GPS	1 - 3	3
HFR1	QVQLQESGGGLVQAGGSLRLSCAASGRTFS	4 - 33	30
CDR-H1	SDVMG	34 - 38	5
HFR2	WFRQAPGKEREFVA	39 - 52	14
CDR-H2	AVTRSGGKSYNADSVKG	53 - 69	17
HFR3	RFTISRDNAKNTVSLQMNSLKPEDTAVYYCAA	70 - 101	32
CDR-H3	GDTAITSWYGYDY	102 - 114	13
HFR4	WGQGTQVTVSS	115 - 125	11
			125

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQAGGSLRLSCAAS-----	4 - 28	25
	AbM	QVQLQESGGGLVQAGGSLRLSCAAS-----	4 - 28	25
	Kabat	QVQLQESGGGLVQAGGSLRLSCAASGRTFS	4 - 33	30
	Contact	QVQLQESGGGLVQAGGSLRLSCAASGRTF-	4 - 32	29
	IMGT	QVQLQESGGGLVQAGGSLRLSCAAS-----	4 - 28	25
CDR-H1	Chothia	GRTFSSD---	29 - 35	7
	AbM	GRTFSSDVMG	29 - 38	10
	Kabat	-----SDVMG	34 - 38	5
	Contact	----SSDVMG	33 - 38	6
	IMGT	GRTFSSDV--	29 - 36	8
HFR2	Chothia	VMGWFRQAPGKEREFVAAV	36 - 54	19
	AbM	---WFRQAPGKEREFVA--	39 - 52	14
	Kabat	---WFRQAPGKEREFVA--	39 - 52	14
	Contact	---WFRQAPGKERE-----	39 - 49	11
	IMGT	-MGWFRQAPGKEREFVAA-	37 - 53	17
CDR-H2	Chothia	-----TRSGGK---------	55 - 60	6
	AbM	---AVTRSGGKSY-------	53 - 62	10
	Kabat	---AVTRSGGKSYNADSVKG	53 - 69	17
	Contact	FVAAVTRSGGKSY-------	50 - 62	13
	IMGT	----VTRSGGKS--------	54 - 61	8
HFR3	Chothia	SYNADSVKGRFTISRDNAKNTVSLQMNSLKPEDTAVYYCAA	61 - 101	41
	AbM	--NADSVKGRFTISRDNAKNTVSLQMNSLKPEDTAVYYCAA	63 - 101	39
	Kabat	---------RFTISRDNAKNTVSLQMNSLKPEDTAVYYCAA	70 - 101	32
	Contact	--NADSVKGRFTISRDNAKNTVSLQMNSLKPEDTAVYYC--	63 - 99	37
	IMGT	-YNADSVKGRFTISRDNAKNTVSLQMNSLKPEDTAVYYC--	62 - 99	38
CDR-H3	Chothia	--GDTAITSWYGYDY	102 - 114	13
	AbM	--GDTAITSWYGYDY	102 - 114	13
	Kabat	--GDTAITSWYGYDY	102 - 114	13
	Contact	AAGDTAITSWYGYD-	100 - 113	14
	IMGT	AAGDTAITSWYGYDY	100 - 114	15
HFR4	Chothia	-WGQGTQVTVSS	115 - 125	11
	AbM	-WGQGTQVTVSS	115 - 125	11
	Kabat	-WGQGTQVTVSS	115 - 125	11
	Contact	YWGQGTQVTVSS	114 - 125	12
	IMGT	-WGQGTQVTVSS	115 - 125	11

Accession & Annotations

Accession	5da4_C
Source	PDB 5da4 Submitted 19-AUG-2015 Updated 14-OCT-2015
Name	STRUCTURE OF A NANOBODY RECOGNIZING THE FUMARATE TRANSPORTER SLC26DG
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 5da4_A 5da4_B
References	GEERTSMA R., CHANG N., SHAIK R., NELDNER Y., PARDON E., STEYAERT J., DUTZLER R. 'STRUCTURE OF A PROKARYOTIC FUMARATE TRANSPORTER REVEALS THE ARCHITECTURE OF THE SLC26 FAMILY.' NAT.STRUCT.MOL.BIOL. V. 22 803 2015 ESSN 1545-9985

Tools

Sequences

Amino Acid Sequence:

GPSQVQLQESGGGLVQAGGSLRLSCAASGRTFSSDVMGWFRQAPGKEREFVAAVTRSGGK
SYNADSVKGRFTISRDNAKNTVSLQMNSLKPEDTAVYYCAAGDTAITSWYGYDYWGQGTQ
VTVSS