abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLVESGGGSVQAGGSLRLSCTASGFTFD	1 - 30	30
CDR-H1	DSDMG	31 - 35	5
HFR2	WYHQAPGNECELVS	36 - 49	14
CDR-H2	AIFSDGSTYYADSVKG	50 - 65	16
HFR3	RFTISRDNAKNTVYLQMNSLKPEDTAMYYCAA	66 - 97	32
CDR-H3	ATTTVASPPVRHVCNGY	98 - 114	17
HFR4	WGQGTQVTVSS	115 - 125	11
Tail	HHHHHH	125 - 131	6
			131

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLVESGGGSVQAGGSLRLSCTAS-----	1 - 25	25
	AbM	QVQLVESGGGSVQAGGSLRLSCTAS-----	1 - 25	25
	Kabat	QVQLVESGGGSVQAGGSLRLSCTASGFTFD	1 - 30	30
	Contact	QVQLVESGGGSVQAGGSLRLSCTASGFTF-	1 - 29	29
	IMGT	QVQLVESGGGSVQAGGSLRLSCTAS-----	1 - 25	25
CDR-H1	Chothia	GFTFDDS---	26 - 32	7
	AbM	GFTFDDSDMG	26 - 35	10
	Kabat	-----DSDMG	31 - 35	5
	Contact	----DDSDMG	30 - 35	6
	IMGT	GFTFDDSD--	26 - 33	8
HFR2	Chothia	DMGWYHQAPGNECELVSAI	33 - 51	19
	AbM	---WYHQAPGNECELVS--	36 - 49	14
	Kabat	---WYHQAPGNECELVS--	36 - 49	14
	Contact	---WYHQAPGNECE-----	36 - 46	11
	IMGT	-MGWYHQAPGNECELVSA-	34 - 50	17
CDR-H2	Chothia	-----FSDGS---------	52 - 56	5
	AbM	---AIFSDGSTY-------	50 - 58	9
	Kabat	---AIFSDGSTYYADSVKG	50 - 65	16
	Contact	LVSAIFSDGSTY-------	47 - 58	12
	IMGT	----IFSDGST--------	51 - 57	7
HFR3	Chothia	TYYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAMYYCAA	57 - 97	41
	AbM	--YADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAMYYCAA	59 - 97	39
	Kabat	---------RFTISRDNAKNTVYLQMNSLKPEDTAMYYCAA	66 - 97	32
	Contact	--YADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAMYYC--	59 - 95	37
	IMGT	-YYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAMYYC--	58 - 95	38
CDR-H3	Chothia	--ATTTVASPPVRHVCNGY	98 - 114	17
	AbM	--ATTTVASPPVRHVCNGY	98 - 114	17
	Kabat	--ATTTVASPPVRHVCNGY	98 - 114	17
	Contact	AAATTTVASPPVRHVCNG-	96 - 113	18
	IMGT	AAATTTVASPPVRHVCNGY	96 - 114	19
HFR4	Chothia	-WGQGTQVTVSS	115 - 125	11
	AbM	-WGQGTQVTVSS	115 - 125	11
	Kabat	-WGQGTQVTVSS	115 - 125	11
	Contact	YWGQGTQVTVSS	114 - 125	12
	IMGT	-WGQGTQVTVSS	115 - 125	11

Accession & Annotations

Accession	5e7b_A
Source	PDB 5e7b Submitted 12-OCT-2015 Updated 04-MAY-2016
Name	STRUCTURE OF A NANOBODY (VHH) FROM CAMEL AGAINST PHAGE TUC2009 RBP (BPPL, ORF53)
Organism	Camelus dromedarius
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 5e7f_A 5e7f_B 5e7f_C
References	LEGRAND P., COLLINS B., BLANGY S., MURPHY J., SPINELLI S., GUTIERREZ C., RICHET N., KELLENBERGER C., DESMYTER A., MAHONY J., VAN SINDEREN D., CAMBILLAU C. 'THE ATOMIC STRUCTURE OF THE PHAGE TUC2009 BASEPLATE TRIPOD SUGGESTS THAT HOST RECOGNITION INVOLVES TWO DIFFERENT CARBOHYDRATE BINDING MODULES.' MBIO V. 7 01781 2016 ESSN 2150-7511

Tools

Sequences

Amino Acid Sequence:

QVQLVESGGGSVQAGGSLRLSCTASGFTFDDSDMGWYHQAPGNECELVSAIFSDGSTYYA
DSVKGRFTISRDNAKNTVYLQMNSLKPEDTAMYYCAAATTTVASPPVRHVCNGYWGQGTQ
VTVSSHHHHHH