abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQPGGSLKLSCAASGFTFS	1 - 30	30
CDR-H1	RYAMS	31 - 35	5
HFR2	WYRQAPGKERESVA	36 - 49	14
CDR-H2	RISSGGGTIYYADSVKG	50 - 66	17
HFR3	RFTISREDAKNTVYLQMNSLKPEDTAVYYCYV	67 - 98	32
CDR-H3	GGF	99 - 101	3
HFR4	WGQGTQVTVSS	102 - 112	11
Tail	GG	112 - 114	2
			114

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQPGGSLKLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGLVQPGGSLKLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGLVQPGGSLKLSCAASGFTFS	1 - 30	30
	Contact	QVQLQESGGGLVQPGGSLKLSCAASGFTF-	1 - 29	29
	IMGT	QVQLQESGGGLVQPGGSLKLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GFTFSRY---	26 - 32	7
	AbM	GFTFSRYAMS	26 - 35	10
	Kabat	-----RYAMS	31 - 35	5
	Contact	----SRYAMS	30 - 35	6
	IMGT	GFTFSRYA--	26 - 33	8
HFR2	Chothia	AMSWYRQAPGKERESVARI	33 - 51	19
	AbM	---WYRQAPGKERESVA--	36 - 49	14
	Kabat	---WYRQAPGKERESVA--	36 - 49	14
	Contact	---WYRQAPGKERE-----	36 - 46	11
	IMGT	-MSWYRQAPGKERESVAR-	34 - 50	17
CDR-H2	Chothia	-----SSGGGT---------	52 - 57	6
	AbM	---RISSGGGTIY-------	50 - 59	10
	Kabat	---RISSGGGTIYYADSVKG	50 - 66	17
	Contact	SVARISSGGGTIY-------	47 - 59	13
	IMGT	----ISSGGGTI--------	51 - 58	8
HFR3	Chothia	IYYADSVKGRFTISREDAKNTVYLQMNSLKPEDTAVYYCYV	58 - 98	41
	AbM	--YADSVKGRFTISREDAKNTVYLQMNSLKPEDTAVYYCYV	60 - 98	39
	Kabat	---------RFTISREDAKNTVYLQMNSLKPEDTAVYYCYV	67 - 98	32
	Contact	--YADSVKGRFTISREDAKNTVYLQMNSLKPEDTAVYYC--	60 - 96	37
	IMGT	-YYADSVKGRFTISREDAKNTVYLQMNSLKPEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--GGF	99 - 101	3
	AbM	--GGF	99 - 101	3
	Kabat	--GGF	99 - 101	3
	Contact	YVGG-	97 - 100	4
	IMGT	YVGGF	97 - 101	5
HFR4	Chothia	-WGQGTQVTVSS	102 - 112	11
	AbM	-WGQGTQVTVSS	102 - 112	11
	Kabat	-WGQGTQVTVSS	102 - 112	11
	Contact	FWGQGTQVTVSS	101 - 112	12
	IMGT	-WGQGTQVTVSS	102 - 112	11

Accession & Annotations

Accession	5h8d_A
Source	PDB 5h8d Submitted 23-DEC-2015 Updated 18-MAY-2016
Name	CRYSTAL STRUCTURE OF AN ASC BINDING NANOBODY
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 5h8o_A
References	SCHMIDT I., LU A., CHEN W., RUAN J., TANG C., WU H., PLOEGH L. 'A SINGLE DOMAIN ANTIBODY FRAGMENT THAT RECOGNIZES THE ADAPTOR ASC DEFINES THE ROLE OF ASC DOMAINS IN INFLAMMASOME ASSEMBLY.' J.EXP.MED. V. 213 771 2016 ESSN 1540-9538

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQPGGSLKLSCAASGFTFSRYAMSWYRQAPGKERESVARISSGGGTIYY
ADSVKGRFTISREDAKNTVYLQMNSLKPEDTAVYYCYVGGFWGQGTQVTVSSGG