abYsis

Numbering & Regions

Comparison Organism:

Calculating, please wait ...

Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQAGGSLRLSCAASGSIFS	1 - 30	30
CDR-H1	PNAMG	31 - 35	5
HFR2	WYRQAPGKERELVA	36 - 49	14
CDR-H2	ARTNVGSTYADSVKG	50 - 64	15
HFR3	RFTVSRDNAKNTVYLQMNSLKPEDTAVYYCNA	65 - 96	32
CDR-H3	WGQDGWLGQYDY	97 - 108	12
HFR4	WGQGTQVTVSS	109 - 119	11
			119

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGLVQAGGSLRLSCAASGSIFS	1 - 30	30
	Contact	QVQLQESGGGLVQAGGSLRLSCAASGSIF-	1 - 29	29
	IMGT	QVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GSIFSPN---	26 - 32	7
	AbM	GSIFSPNAMG	26 - 35	10
	Kabat	-----PNAMG	31 - 35	5
	Contact	----SPNAMG	30 - 35	6
	IMGT	GSIFSPNA--	26 - 33	8
HFR2	Chothia	AMGWYRQAPGKERELVAAR	33 - 51	19
	AbM	---WYRQAPGKERELVA--	36 - 49	14
	Kabat	---WYRQAPGKERELVA--	36 - 49	14
	Contact	---WYRQAPGKERE-----	36 - 46	11
	IMGT	-MGWYRQAPGKERELVAA-	34 - 50	17
CDR-H2	Chothia	-----TNVG---------	52 - 55	4
	AbM	---ARTNVGST-------	50 - 57	8
	Kabat	---ARTNVGSTYADSVKG	50 - 64	15
	Contact	LVAARTNVGST-------	47 - 57	11
	IMGT	----RTNVGS--------	51 - 56	6
HFR3	Chothia	STYADSVKGRFTVSRDNAKNTVYLQMNSLKPEDTAVYYCNA	56 - 96	41
	AbM	--YADSVKGRFTVSRDNAKNTVYLQMNSLKPEDTAVYYCNA	58 - 96	39
	Kabat	---------RFTVSRDNAKNTVYLQMNSLKPEDTAVYYCNA	65 - 96	32
	Contact	--YADSVKGRFTVSRDNAKNTVYLQMNSLKPEDTAVYYC--	58 - 94	37
	IMGT	-TYADSVKGRFTVSRDNAKNTVYLQMNSLKPEDTAVYYC--	57 - 94	38
CDR-H3	Chothia	--WGQDGWLGQYDY	97 - 108	12
	AbM	--WGQDGWLGQYDY	97 - 108	12
	Kabat	--WGQDGWLGQYDY	97 - 108	12
	Contact	NAWGQDGWLGQYD-	95 - 107	13
	IMGT	NAWGQDGWLGQYDY	95 - 108	14
HFR4	Chothia	-WGQGTQVTVSS	109 - 119	11
	AbM	-WGQGTQVTVSS	109 - 119	11
	Kabat	-WGQGTQVTVSS	109 - 119	11
	Contact	YWGQGTQVTVSS	108 - 119	12
	IMGT	-WGQGTQVTVSS	109 - 119	11

Accession & Annotations

Accession	5hvf_B
Source	PDB 5hvf Submitted 28-JAN-2016 Updated 31-AUG-2016
Name	CRYSTAL STRUCTURE OF THROMBIN-ACTIVATABLE FIBRINOLYSIS INHIBITOR IN COMPLEX WITH AN INHIBITORY NANOBODY (VHH-I83)
Organism	Vicugna pacos
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	ZHOU X., WEEKS D., AMELOOT P., CALLEWAERT N., STRELKOV V., DECLERCK J. 'ELUCIDATION OF THE MOLECULAR MECHANISMS OF TWO NANOBODIES THAT INHIBIT THROMBIN-ACTIVATABLE FIBRINOLYSIS INHIBITOR ACTIVATION AND ACTIVATED THROMBIN-ACTIVATABLE FIBRINOLYSIS INHIBITOR ACTIVITY.' J.THROMB.HAEMOST. V. 14 1629 2016 ESSN 1538-7836

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQAGGSLRLSCAASGSIFSPNAMGWYRQAPGKERELVAARTNVGSTYAD
SVKGRFTVSRDNAKNTVYLQMNSLKPEDTAVYYCNAWGQDGWLGQYDYWGQGTQVTVSS