abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQPGGSLRLSCAASGSIFS	1 - 30	30
CDR-H1	GNAMG	31 - 35	5
HFR2	WYRQAPGKQRELVA	36 - 49	14
CDR-H2	AITSGGSTDYADSVKG	50 - 65	16
HFR3	RFTISRDNAKNTVYLQMNSLKPEDTAVYYCHV	66 - 97	32
CDR-H3	DPRPWGYDVTDYDY	98 - 111	14
HFR4	WGQGTQVTVSS	112 - 122	11
Tail	HHHHHH	122 - 128	6
			128

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGLVQPGGSLRLSCAASGSIFS	1 - 30	30
	Contact	QVQLQESGGGLVQPGGSLRLSCAASGSIF-	1 - 29	29
	IMGT	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GSIFSGN---	26 - 32	7
	AbM	GSIFSGNAMG	26 - 35	10
	Kabat	-----GNAMG	31 - 35	5
	Contact	----SGNAMG	30 - 35	6
	IMGT	GSIFSGNA--	26 - 33	8
HFR2	Chothia	AMGWYRQAPGKQRELVAAI	33 - 51	19
	AbM	---WYRQAPGKQRELVA--	36 - 49	14
	Kabat	---WYRQAPGKQRELVA--	36 - 49	14
	Contact	---WYRQAPGKQRE-----	36 - 46	11
	IMGT	-MGWYRQAPGKQRELVAA-	34 - 50	17
CDR-H2	Chothia	-----TSGGS---------	52 - 56	5
	AbM	---AITSGGSTD-------	50 - 58	9
	Kabat	---AITSGGSTDYADSVKG	50 - 65	16
	Contact	LVAAITSGGSTD-------	47 - 58	12
	IMGT	----ITSGGST--------	51 - 57	7
HFR3	Chothia	TDYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCHV	57 - 97	41
	AbM	--YADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCHV	59 - 97	39
	Kabat	---------RFTISRDNAKNTVYLQMNSLKPEDTAVYYCHV	66 - 97	32
	Contact	--YADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYC--	59 - 95	37
	IMGT	-DYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--DPRPWGYDVTDYDY	98 - 111	14
	AbM	--DPRPWGYDVTDYDY	98 - 111	14
	Kabat	--DPRPWGYDVTDYDY	98 - 111	14
	Contact	HVDPRPWGYDVTDYD-	96 - 110	15
	IMGT	HVDPRPWGYDVTDYDY	96 - 111	16
HFR4	Chothia	-WGQGTQVTVSS	112 - 122	11
	AbM	-WGQGTQVTVSS	112 - 122	11
	Kabat	-WGQGTQVTVSS	112 - 122	11
	Contact	YWGQGTQVTVSS	111 - 122	12
	IMGT	-WGQGTQVTVSS	112 - 122	11

Accession & Annotations

Accession	5hvg_B
Source	PDB 5hvg Submitted 28-JAN-2016 Updated 31-AUG-2016
Name	CRYSTAL STRUCTURE OF THROMBIN-ACTIVATABLE FIBRINOLYSIS INHIBITOR IN COMPLEX WITH AN INHIBITORY NANOBODY (VHH-A204)
Organism	Vicugna pacos
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 5hvg_D 5hvh_B
References	ZHOU X., WEEKS D., AMELOOT P., CALLEWAERT N., STRELKOV V., DECLERCK J. 'ELUCIDATION OF THE MOLECULAR MECHANISMS OF TWO NANOBODIES THAT INHIBIT THROMBIN-ACTIVATABLE FIBRINOLYSIS INHIBITOR ACTIVATION AND ACTIVATED THROMBIN-ACTIVATABLE FIBRINOLYSIS INHIBITOR ACTIVITY.' J.THROMB.HAEMOST. V. 14 1629 2016 ESSN 1538-7836

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQPGGSLRLSCAASGSIFSGNAMGWYRQAPGKQRELVAAITSGGSTDYA
DSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCHVDPRPWGYDVTDYDYWGQGTQVTV
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